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Large vessel cerebral atherosclerosis is not in direct association with neuropathological lesions of Alzheimer's disease.
Eur Neurol 2009; 62(2):93-8EN

Abstract

INTRODUCTION

Cerebral hypoperfusion caused by large vessel atherosclerosis has been suggested to be associated with the pathogenesis of sporadic Alzheimer's disease (AD). Atherosclerosis and AD share risk factors such as age, diabetes, hypercholesterolemia, hypertension and apolipoprotein E epsilon4 (APOE epsilon4) allele. We studied the association between atherosclerosis of the circle of Willis (CW) and AD neuropathology in a large autopsy sample.

METHODS

The present study comprised a consecutive autopsy series (n = 466) representing noninstitutionalized general population aged 50 years and over (mean 70.8, SD 11.5 years). The atherosclerosis of CW was scored semiquantitatively and the amyloid plaque (AP) load in the frontal cortex and the number of neurofibrillary tangles (NFT) in the hippocampus were measured.

RESULTS

In a linear regression model, AP percentage area was associated with age (p < 0.0001) and APOE epsilon4 allele (p < 0.0001), but not with CW score (p = 0.70) or gender (p = 0.11). Similarly, the NFT count was predicted only by age (p > 0.0001), and not by CW score (p = 0.36), gender (p = 0.41) or APOE epsilon4 allele (p = 0.072).

CONCLUSION

Our results suggest that cerebral large vessel atherosclerosis is not in direct association with APs or NFTs - hallmarks of AD neuropathology.

Authors+Show Affiliations

Department of Forensic Medicine, University of Tampere, Tampere, Finland. Teemu.Luoto@uta.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19521084

Citation

Luoto, Teemu M., et al. "Large Vessel Cerebral Atherosclerosis Is Not in Direct Association With Neuropathological Lesions of Alzheimer's Disease." European Neurology, vol. 62, no. 2, 2009, pp. 93-8.
Luoto TM, Haikonen S, Haapasalo H, et al. Large vessel cerebral atherosclerosis is not in direct association with neuropathological lesions of Alzheimer's disease. Eur Neurol. 2009;62(2):93-8.
Luoto, T. M., Haikonen, S., Haapasalo, H., Goebeler, S., Huhtala, H., Erkinjuntti, T., & Karhunen, P. J. (2009). Large vessel cerebral atherosclerosis is not in direct association with neuropathological lesions of Alzheimer's disease. European Neurology, 62(2), pp. 93-8. doi:10.1159/000222779.
Luoto TM, et al. Large Vessel Cerebral Atherosclerosis Is Not in Direct Association With Neuropathological Lesions of Alzheimer's Disease. Eur Neurol. 2009;62(2):93-8. PubMed PMID: 19521084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large vessel cerebral atherosclerosis is not in direct association with neuropathological lesions of Alzheimer's disease. AU - Luoto,Teemu M, AU - Haikonen,Satu, AU - Haapasalo,Hannu, AU - Goebeler,Sirkka, AU - Huhtala,Heini, AU - Erkinjuntti,Timo, AU - Karhunen,Pekka J, Y1 - 2009/06/12/ PY - 2009/01/05/received PY - 2009/04/02/accepted PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/9/23/medline SP - 93 EP - 8 JF - European neurology JO - Eur. Neurol. VL - 62 IS - 2 N2 - INTRODUCTION: Cerebral hypoperfusion caused by large vessel atherosclerosis has been suggested to be associated with the pathogenesis of sporadic Alzheimer's disease (AD). Atherosclerosis and AD share risk factors such as age, diabetes, hypercholesterolemia, hypertension and apolipoprotein E epsilon4 (APOE epsilon4) allele. We studied the association between atherosclerosis of the circle of Willis (CW) and AD neuropathology in a large autopsy sample. METHODS: The present study comprised a consecutive autopsy series (n = 466) representing noninstitutionalized general population aged 50 years and over (mean 70.8, SD 11.5 years). The atherosclerosis of CW was scored semiquantitatively and the amyloid plaque (AP) load in the frontal cortex and the number of neurofibrillary tangles (NFT) in the hippocampus were measured. RESULTS: In a linear regression model, AP percentage area was associated with age (p < 0.0001) and APOE epsilon4 allele (p < 0.0001), but not with CW score (p = 0.70) or gender (p = 0.11). Similarly, the NFT count was predicted only by age (p > 0.0001), and not by CW score (p = 0.36), gender (p = 0.41) or APOE epsilon4 allele (p = 0.072). CONCLUSION: Our results suggest that cerebral large vessel atherosclerosis is not in direct association with APs or NFTs - hallmarks of AD neuropathology. SN - 1421-9913 UR - https://www.unboundmedicine.com/medline/citation/19521084/Large_vessel_cerebral_atherosclerosis_is_not_in_direct_association_with_neuropathological_lesions_of_Alzheimer's_disease_ L2 - https://www.karger.com?DOI=10.1159/000222779 DB - PRIME DP - Unbound Medicine ER -