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Red wine consumption and risk of prostate cancer: the California men's health study.
Int J Cancer 2010; 126(1):171-9IJ

Abstract

Red wine contains polyphenol antioxidants that inhibit prostate cancer development in animal studies. We investigated the effect of red wine intake on the risk of prostate cancer using data prospectively collected in the California Men's Health Study (CMHS). CMHS is a multiethnic cohort of 84,170 men aged 45-69 years who were members of the Kaiser Permanente Southern and Northern California Health Plans. Information on demographic and lifestyle factors was collected using mailed questionnaires between 2002 and 2003. We used Cox models to estimate the effect of red wine on prostate cancer risk, adjusting for potential confounders. A total of 1,340 incident prostate cancer cases identified from Surveillance, Epidemiology and End Result-affiliated cancer registries were included in the analyses. We did not find a clear association between red wine intake and risk of prostate cancer. Hazard ratio (HR) estimates for consuming <1 drink/week, > or =1 drink/week but <1 drink/day and > or =1 drink/day were 0.89, 95% confidence interval (0.74-1.07), 0.99 (0.83-1.17) and 0.88 (0.70-1.12), respectively. Further, we observed no linear dose response. The lack of association for red wine intake was consistently observed when we restricted the analyses to those with and without a history of PSA screening. In addition, we also did not observe any association with prostate cancer for beer, white wine, liquor or combined alcoholic beverage intake (HR for combined alcoholic beverage intake of > or =5 drinks/day = 1.16 (0.83-1.63). Neither red wine nor total alcohol consumption were associated with prostate cancer risk in this population of moderate drinkers.

Authors+Show Affiliations

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, USA. chun.r.chao@kp.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19521962

Citation

Chao, Chun, et al. "Red Wine Consumption and Risk of Prostate Cancer: the California Men's Health Study." International Journal of Cancer, vol. 126, no. 1, 2010, pp. 171-9.
Chao C, Haque R, Van Den Eeden SK, et al. Red wine consumption and risk of prostate cancer: the California men's health study. Int J Cancer. 2010;126(1):171-9.
Chao, C., Haque, R., Van Den Eeden, S. K., Caan, B. J., Poon, K. Y., & Quinn, V. P. (2010). Red wine consumption and risk of prostate cancer: the California men's health study. International Journal of Cancer, 126(1), pp. 171-9. doi:10.1002/ijc.24637.
Chao C, et al. Red Wine Consumption and Risk of Prostate Cancer: the California Men's Health Study. Int J Cancer. 2010 Jan 1;126(1):171-9. PubMed PMID: 19521962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red wine consumption and risk of prostate cancer: the California men's health study. AU - Chao,Chun, AU - Haque,Reina, AU - Van Den Eeden,Stephen K, AU - Caan,Bette J, AU - Poon,Kwun-Yee T, AU - Quinn,Virginia P, PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/12/16/medline SP - 171 EP - 9 JF - International journal of cancer JO - Int. J. Cancer VL - 126 IS - 1 N2 - Red wine contains polyphenol antioxidants that inhibit prostate cancer development in animal studies. We investigated the effect of red wine intake on the risk of prostate cancer using data prospectively collected in the California Men's Health Study (CMHS). CMHS is a multiethnic cohort of 84,170 men aged 45-69 years who were members of the Kaiser Permanente Southern and Northern California Health Plans. Information on demographic and lifestyle factors was collected using mailed questionnaires between 2002 and 2003. We used Cox models to estimate the effect of red wine on prostate cancer risk, adjusting for potential confounders. A total of 1,340 incident prostate cancer cases identified from Surveillance, Epidemiology and End Result-affiliated cancer registries were included in the analyses. We did not find a clear association between red wine intake and risk of prostate cancer. Hazard ratio (HR) estimates for consuming <1 drink/week, > or =1 drink/week but <1 drink/day and > or =1 drink/day were 0.89, 95% confidence interval (0.74-1.07), 0.99 (0.83-1.17) and 0.88 (0.70-1.12), respectively. Further, we observed no linear dose response. The lack of association for red wine intake was consistently observed when we restricted the analyses to those with and without a history of PSA screening. In addition, we also did not observe any association with prostate cancer for beer, white wine, liquor or combined alcoholic beverage intake (HR for combined alcoholic beverage intake of > or =5 drinks/day = 1.16 (0.83-1.63). Neither red wine nor total alcohol consumption were associated with prostate cancer risk in this population of moderate drinkers. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/19521962/Red_wine_consumption_and_risk_of_prostate_cancer:_the_California_men's_health_study_ L2 - https://doi.org/10.1002/ijc.24637 DB - PRIME DP - Unbound Medicine ER -