Tags

Type your tag names separated by a space and hit enter

Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male Finnish military conscripts.
J Eur Acad Dermatol Venereol. 2009 Nov; 23(11):1294-7.JE

Abstract

OBJECTIVE

To investigate the putative association between isotretinoin treatment and depressive symptoms or suicidal ideation among Finnish male military conscripts. METHODS; Consecutive acne patients were enrolled into an uncontrolled, prospective 12-week follow-up study conducted at the Central Military Hospital, Helsinki, Finland. Of the 135 patients prescribed isotretinoin, 126 (93.3%) completed the follow-up. Depression and suicidal ideation were investigated with the Beck Depression Inventory (BDI) at baseline, weeks 4-6, and weeks 10-12.

RESULTS

BDI mean score was low at baseline and declined further significantly (p < 0.001) during the follow-up from 3.0 (SD 3.948) to 1.8 (SD 3.783) among patients on isotretinoin. Moreover, the proportion of patients with clinically significant depressive symptoms (BDI > or= 10) declined non-significantly from 7.1 % to 3.2 %. Suicidal ideation was reported by 17 (13.5 %) patients at baseline and 9 (7.1%) patients at the end of the follow-up (NS). During the follow-up, one non-depressed patient attempted suicide while intoxicated by alcohol.

CONCLUSION

On group level, isotretinoin seems not to be typically associated with treatment-emergent depression or suicidal ideation among young men. However, the possibility that individual patients may be susceptible for mood effects of isotretinoin as a rare idiosyncratic reaction can not be excluded.

Authors+Show Affiliations

Helsinki City Health Center, Department of Psychiatry, Helsinki, Finland. laura.rehn@hel.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

19522777

Citation

Rehn, L M H., et al. "Depressive Symptoms and Suicidal Ideation During Isotretinoin Treatment: a 12-week Follow-up Study of Male Finnish Military Conscripts." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 23, no. 11, 2009, pp. 1294-7.
Rehn LM, Meririnne E, Höök-Nikanne J, et al. Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male Finnish military conscripts. J Eur Acad Dermatol Venereol. 2009;23(11):1294-7.
Rehn, L. M., Meririnne, E., Höök-Nikanne, J., Isometsä, E., & Henriksson, M. (2009). Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male Finnish military conscripts. Journal of the European Academy of Dermatology and Venereology : JEADV, 23(11), 1294-7. https://doi.org/10.1111/j.1468-3083.2009.03313.x
Rehn LM, et al. Depressive Symptoms and Suicidal Ideation During Isotretinoin Treatment: a 12-week Follow-up Study of Male Finnish Military Conscripts. J Eur Acad Dermatol Venereol. 2009;23(11):1294-7. PubMed PMID: 19522777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male Finnish military conscripts. AU - Rehn,L M H, AU - Meririnne,E, AU - Höök-Nikanne,J, AU - Isometsä,E, AU - Henriksson,M, Y1 - 2009/06/11/ PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2010/1/12/medline SP - 1294 EP - 7 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 23 IS - 11 N2 - OBJECTIVE: To investigate the putative association between isotretinoin treatment and depressive symptoms or suicidal ideation among Finnish male military conscripts. METHODS; Consecutive acne patients were enrolled into an uncontrolled, prospective 12-week follow-up study conducted at the Central Military Hospital, Helsinki, Finland. Of the 135 patients prescribed isotretinoin, 126 (93.3%) completed the follow-up. Depression and suicidal ideation were investigated with the Beck Depression Inventory (BDI) at baseline, weeks 4-6, and weeks 10-12. RESULTS: BDI mean score was low at baseline and declined further significantly (p < 0.001) during the follow-up from 3.0 (SD 3.948) to 1.8 (SD 3.783) among patients on isotretinoin. Moreover, the proportion of patients with clinically significant depressive symptoms (BDI > or= 10) declined non-significantly from 7.1 % to 3.2 %. Suicidal ideation was reported by 17 (13.5 %) patients at baseline and 9 (7.1%) patients at the end of the follow-up (NS). During the follow-up, one non-depressed patient attempted suicide while intoxicated by alcohol. CONCLUSION: On group level, isotretinoin seems not to be typically associated with treatment-emergent depression or suicidal ideation among young men. However, the possibility that individual patients may be susceptible for mood effects of isotretinoin as a rare idiosyncratic reaction can not be excluded. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/19522777/Depressive_symptoms_and_suicidal_ideation_during_isotretinoin_treatment:_a_12_week_follow_up_study_of_male_Finnish_military_conscripts_ L2 - https://doi.org/10.1111/j.1468-3083.2009.03313.x DB - PRIME DP - Unbound Medicine ER -