Tags

Type your tag names separated by a space and hit enter

Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children.
Clin Exp Allergy. 2009 Jun; 39(6):875-82.CE

Abstract

BACKGROUND

Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases. Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes.

METHODS

Children (1669) participating in the population-based birth cohort study were followed for asthma, AR, and atopic eczema assessed by validated questionnaire at 5 years. Maternal diet was assessed by a food-frequency questionnaire.

RESULTS

The mean maternal intake of vitamin D was 5.1 (SD 2.6) microg from food and 1.4 (2.6) microg from supplements. Only 32% of the women were taking vitamin D supplements. When adjusted for potential confounders, maternal intake of vitamin D from food was negatively related to risk of asthma [hazard ratio (HR) 0.80; 95% confidence interval (CI) 0.64-0.99] and AR [HR 0.85; 95% CI 0.75-0.97]. Vitamin D supplements alone were not associated with any outcome. Adjustment for maternal intake of other dietary factors did not change the results.

CONCLUSION

Maternal vitamin D intake from foods during pregnancy may be negatively associated with risk of asthma and AR in childhood.

Authors+Show Affiliations

Division of Nutrition, Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland. maijaliisa.erkkola@helsinki.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19522996

Citation

Erkkola, M, et al. "Maternal Vitamin D Intake During Pregnancy Is Inversely Associated With Asthma and Allergic Rhinitis in 5-year-old Children." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 39, no. 6, 2009, pp. 875-82.
Erkkola M, Kaila M, Nwaru BI, et al. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy. 2009;39(6):875-82.
Erkkola, M., Kaila, M., Nwaru, B. I., Kronberg-Kippilä, C., Ahonen, S., Nevalainen, J., Veijola, R., Pekkanen, J., Ilonen, J., Simell, O., Knip, M., & Virtanen, S. M. (2009). Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 39(6), 875-82. https://doi.org/10.1111/j.1365-2222.2009.03234.x
Erkkola M, et al. Maternal Vitamin D Intake During Pregnancy Is Inversely Associated With Asthma and Allergic Rhinitis in 5-year-old Children. Clin Exp Allergy. 2009;39(6):875-82. PubMed PMID: 19522996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. AU - Erkkola,M, AU - Kaila,M, AU - Nwaru,B I, AU - Kronberg-Kippilä,C, AU - Ahonen,S, AU - Nevalainen,J, AU - Veijola,R, AU - Pekkanen,J, AU - Ilonen,J, AU - Simell,O, AU - Knip,M, AU - Virtanen,S M, PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2009/8/27/medline SP - 875 EP - 82 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 39 IS - 6 N2 - BACKGROUND: Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases. Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes. METHODS: Children (1669) participating in the population-based birth cohort study were followed for asthma, AR, and atopic eczema assessed by validated questionnaire at 5 years. Maternal diet was assessed by a food-frequency questionnaire. RESULTS: The mean maternal intake of vitamin D was 5.1 (SD 2.6) microg from food and 1.4 (2.6) microg from supplements. Only 32% of the women were taking vitamin D supplements. When adjusted for potential confounders, maternal intake of vitamin D from food was negatively related to risk of asthma [hazard ratio (HR) 0.80; 95% confidence interval (CI) 0.64-0.99] and AR [HR 0.85; 95% CI 0.75-0.97]. Vitamin D supplements alone were not associated with any outcome. Adjustment for maternal intake of other dietary factors did not change the results. CONCLUSION: Maternal vitamin D intake from foods during pregnancy may be negatively associated with risk of asthma and AR in childhood. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/19522996/Maternal_vitamin_D_intake_during_pregnancy_is_inversely_associated_with_asthma_and_allergic_rhinitis_in_5_year_old_children_ L2 - https://doi.org/10.1111/j.1365-2222.2009.03234.x DB - PRIME DP - Unbound Medicine ER -