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Clinical trial: lansoprazole 15 or 30 mg once daily vs. placebo for treatment of frequent nighttime heartburn in self-treating subjects.
Aliment Pharmacol Ther. 2009 Sep 01; 30(5):459-68.AP

Abstract

BACKGROUND

Frequent nighttime heartburn is common. Lansoprazole 15 mg is indicated for treatment of heartburn and other gastro-oesophageal reflux disease-related symptoms.

AIM

To evaluate the efficacy and safety of lansoprazole in self-treating subjects with frequent nocturnal heartburn.

METHODS

A total of 864 subjects with heartburn on >or=2 days/week over the past month were randomized to double-blind treatment with lansoprazole 15 or 30 mg or placebo each morning. Endpoints were percentage of night times without heartburn (primary), percentage of 24-h days without heartburn and percentage of subjects without heartburn on day 1.

RESULTS

Mean percentage of night times without heartburn was significantly greater with lansoprazole 15 mg (61.3%) or lansoprazole 30 mg (61.7%) vs. placebo (47.8%) over 14 days (P < 0.0001 vs. placebo for both doses). Percentage of 24-h days without heartburn and percentage of subjects without heartburn on day 1 were significantly greater with lansoprazole 15 or 30 mg vs. placebo.

CONCLUSIONS

Both lansoprazole 15 and 30 mg were highly effective and well tolerated in reducing symptoms in subjects with frequent nighttime heartburn. The benefit of therapy on 24-h heartburn and nighttime heartburn on day 1 of treatment was also evident. Lansoprazole 15 mg is a suitable choice for management of frequent nighttime heartburn.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908-0708, USA. dap8v@virginia.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19523177

Citation

Peura, D A., et al. "Clinical Trial: Lansoprazole 15 or 30 Mg once Daily Vs. Placebo for Treatment of Frequent Nighttime Heartburn in Self-treating Subjects." Alimentary Pharmacology & Therapeutics, vol. 30, no. 5, 2009, pp. 459-68.
Peura DA, Riff DS, Snoddy AM, et al. Clinical trial: lansoprazole 15 or 30 mg once daily vs. placebo for treatment of frequent nighttime heartburn in self-treating subjects. Aliment Pharmacol Ther. 2009;30(5):459-68.
Peura, D. A., Riff, D. S., Snoddy, A. M., & Fennerty, M. B. (2009). Clinical trial: lansoprazole 15 or 30 mg once daily vs. placebo for treatment of frequent nighttime heartburn in self-treating subjects. Alimentary Pharmacology & Therapeutics, 30(5), 459-68. https://doi.org/10.1111/j.1365-2036.2009.04064.x
Peura DA, et al. Clinical Trial: Lansoprazole 15 or 30 Mg once Daily Vs. Placebo for Treatment of Frequent Nighttime Heartburn in Self-treating Subjects. Aliment Pharmacol Ther. 2009 Sep 1;30(5):459-68. PubMed PMID: 19523177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical trial: lansoprazole 15 or 30 mg once daily vs. placebo for treatment of frequent nighttime heartburn in self-treating subjects. AU - Peura,D A, AU - Riff,D S, AU - Snoddy,A M, AU - Fennerty,M B, Y1 - 2009/06/11/ PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2010/4/17/medline SP - 459 EP - 68 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 30 IS - 5 N2 - BACKGROUND: Frequent nighttime heartburn is common. Lansoprazole 15 mg is indicated for treatment of heartburn and other gastro-oesophageal reflux disease-related symptoms. AIM: To evaluate the efficacy and safety of lansoprazole in self-treating subjects with frequent nocturnal heartburn. METHODS: A total of 864 subjects with heartburn on >or=2 days/week over the past month were randomized to double-blind treatment with lansoprazole 15 or 30 mg or placebo each morning. Endpoints were percentage of night times without heartburn (primary), percentage of 24-h days without heartburn and percentage of subjects without heartburn on day 1. RESULTS: Mean percentage of night times without heartburn was significantly greater with lansoprazole 15 mg (61.3%) or lansoprazole 30 mg (61.7%) vs. placebo (47.8%) over 14 days (P < 0.0001 vs. placebo for both doses). Percentage of 24-h days without heartburn and percentage of subjects without heartburn on day 1 were significantly greater with lansoprazole 15 or 30 mg vs. placebo. CONCLUSIONS: Both lansoprazole 15 and 30 mg were highly effective and well tolerated in reducing symptoms in subjects with frequent nighttime heartburn. The benefit of therapy on 24-h heartburn and nighttime heartburn on day 1 of treatment was also evident. Lansoprazole 15 mg is a suitable choice for management of frequent nighttime heartburn. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/19523177/Clinical_trial:_lansoprazole_15_or_30_mg_once_daily_vs__placebo_for_treatment_of_frequent_nighttime_heartburn_in_self_treating_subjects_ L2 - https://doi.org/10.1111/j.1365-2036.2009.04064.x DB - PRIME DP - Unbound Medicine ER -