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Insights from investigating the interaction of oseltamivir (Tamiflu) with neuraminidase of the 2009 H1N1 swine flu virus.
Biochem Biophys Res Commun. 2009 Aug 28; 386(3):432-6.BB

Abstract

The neuraminidase (NA) of influenza virus is the target of anti-flu drugs oseltamivir and zanamivir. Clinical practices showed that oseltamivir was effective to treat the 2009-H1N1 influenza but failed to the 2006-H5N1 avian influenza. To perform an in-depth analysis on such a drug-resistance problem, the 2009-H1N1-NA structure was developed. To compare it with the crystal 2006-H5N1-NA structure as well as the 1918 influenza virus H1N1-NA structure, the multiple sequential and structural alignments were performed. It has been revealed that the hydrophobic residue Try347 in H5N1-NA does not match with the hydrophilic carboxyl group of oseltamivir as in the case of H1N1-NA. This may be the reason why H5N1 avian influenza virus is drug-resistant to oseltamivir. The finding provides useful insights for how to modify the existing drugs, such as oseltamivir and zanamivir, making them not only become more effective against H1N1 virus but also effective against H5N1 virus.

Authors+Show Affiliations

College of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19523442

Citation

Wang, Shu-Qing, et al. "Insights From Investigating the Interaction of Oseltamivir (Tamiflu) With Neuraminidase of the 2009 H1N1 Swine Flu Virus." Biochemical and Biophysical Research Communications, vol. 386, no. 3, 2009, pp. 432-6.
Wang SQ, Du QS, Huang RB, et al. Insights from investigating the interaction of oseltamivir (Tamiflu) with neuraminidase of the 2009 H1N1 swine flu virus. Biochem Biophys Res Commun. 2009;386(3):432-6.
Wang, S. Q., Du, Q. S., Huang, R. B., Zhang, D. W., & Chou, K. C. (2009). Insights from investigating the interaction of oseltamivir (Tamiflu) with neuraminidase of the 2009 H1N1 swine flu virus. Biochemical and Biophysical Research Communications, 386(3), 432-6. https://doi.org/10.1016/j.bbrc.2009.06.016
Wang SQ, et al. Insights From Investigating the Interaction of Oseltamivir (Tamiflu) With Neuraminidase of the 2009 H1N1 Swine Flu Virus. Biochem Biophys Res Commun. 2009 Aug 28;386(3):432-6. PubMed PMID: 19523442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insights from investigating the interaction of oseltamivir (Tamiflu) with neuraminidase of the 2009 H1N1 swine flu virus. AU - Wang,Shu-Qing, AU - Du,Qi-Shi, AU - Huang,Ri-Bo, AU - Zhang,Da-Wei, AU - Chou,Kuo-Chen, Y1 - 2009/06/10/ PY - 2009/05/31/received PY - 2009/06/05/accepted PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2009/8/6/medline SP - 432 EP - 6 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 386 IS - 3 N2 - The neuraminidase (NA) of influenza virus is the target of anti-flu drugs oseltamivir and zanamivir. Clinical practices showed that oseltamivir was effective to treat the 2009-H1N1 influenza but failed to the 2006-H5N1 avian influenza. To perform an in-depth analysis on such a drug-resistance problem, the 2009-H1N1-NA structure was developed. To compare it with the crystal 2006-H5N1-NA structure as well as the 1918 influenza virus H1N1-NA structure, the multiple sequential and structural alignments were performed. It has been revealed that the hydrophobic residue Try347 in H5N1-NA does not match with the hydrophilic carboxyl group of oseltamivir as in the case of H1N1-NA. This may be the reason why H5N1 avian influenza virus is drug-resistant to oseltamivir. The finding provides useful insights for how to modify the existing drugs, such as oseltamivir and zanamivir, making them not only become more effective against H1N1 virus but also effective against H5N1 virus. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/19523442/Insights_from_investigating_the_interaction_of_oseltamivir__Tamiflu__with_neuraminidase_of_the_2009_H1N1_swine_flu_virus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(09)01141-3 DB - PRIME DP - Unbound Medicine ER -