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Project DyAdd: Fatty acids in adult dyslexia, ADHD, and their comorbid combination.

Abstract

In project DyAdd, we compared the fatty acid (FA) profiles of serum phospholipids in adults with attention deficit hyperactivity disorder (ADHD) (n=26), dyslexia (n=36), their comorbid combination (n=9), and healthy controls (n=36). FA proportions were analyzed in a 2x2 design with Bonferroni corrected post hoc comparisons. A questionnaire was used to assess dietary fat quality and use of supplements. Results showed that ADHD and dyslexia were not associated with total saturated FAs, monounsaturated FAs, or n-3 polyunsaturated FAs (PUFAs). However, those with ADHD had elevated proportions of total n-6 PUFAs (including gamma-linolenic and adrenic acids) as compared to those without ADHD. Dyslexia was related to a higher proportion of monounsaturated nervonic acid and a higher ratio of n-6/n-3 PUFAs. Among females none of the associations were significant. However in males, all the original associations observed in all subjects remained and ADHD was associated with elevated nervonic acid and n-6/n-3 PUFA ratio like dyslexia. Controlling for poorly diagnosed reading difficulties, education, dietary fat quality, or use of FA supplements did not generally remove the originally observed associations.

Authors+Show Affiliations

Department of Psychology, University of Helsinki, P.O. Box 9 (Siltavuorenpenger 20), FIN-00014, Helsinki, Finland. Marja.Laasonen@helsinki.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19523794

Citation

Laasonen, Marja, et al. "Project DyAdd: Fatty Acids in Adult Dyslexia, ADHD, and Their Comorbid Combination." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 81, no. 1, 2009, pp. 89-96.
Laasonen M, Hokkanen L, Leppämäki S, et al. Project DyAdd: Fatty acids in adult dyslexia, ADHD, and their comorbid combination. Prostaglandins Leukot Essent Fatty Acids. 2009;81(1):89-96.
Laasonen, M., Hokkanen, L., Leppämäki, S., Tani, P., & Erkkilä, A. T. (2009). Project DyAdd: Fatty acids in adult dyslexia, ADHD, and their comorbid combination. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 81(1), 89-96. https://doi.org/10.1016/j.plefa.2009.04.005
Laasonen M, et al. Project DyAdd: Fatty Acids in Adult Dyslexia, ADHD, and Their Comorbid Combination. Prostaglandins Leukot Essent Fatty Acids. 2009;81(1):89-96. PubMed PMID: 19523794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Project DyAdd: Fatty acids in adult dyslexia, ADHD, and their comorbid combination. AU - Laasonen,Marja, AU - Hokkanen,Laura, AU - Leppämäki,Sami, AU - Tani,Pekka, AU - Erkkilä,Arja T, Y1 - 2009/06/11/ PY - 2008/10/13/received PY - 2009/01/06/revised PY - 2009/04/21/accepted PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2009/9/4/medline SP - 89 EP - 96 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 81 IS - 1 N2 - In project DyAdd, we compared the fatty acid (FA) profiles of serum phospholipids in adults with attention deficit hyperactivity disorder (ADHD) (n=26), dyslexia (n=36), their comorbid combination (n=9), and healthy controls (n=36). FA proportions were analyzed in a 2x2 design with Bonferroni corrected post hoc comparisons. A questionnaire was used to assess dietary fat quality and use of supplements. Results showed that ADHD and dyslexia were not associated with total saturated FAs, monounsaturated FAs, or n-3 polyunsaturated FAs (PUFAs). However, those with ADHD had elevated proportions of total n-6 PUFAs (including gamma-linolenic and adrenic acids) as compared to those without ADHD. Dyslexia was related to a higher proportion of monounsaturated nervonic acid and a higher ratio of n-6/n-3 PUFAs. Among females none of the associations were significant. However in males, all the original associations observed in all subjects remained and ADHD was associated with elevated nervonic acid and n-6/n-3 PUFA ratio like dyslexia. Controlling for poorly diagnosed reading difficulties, education, dietary fat quality, or use of FA supplements did not generally remove the originally observed associations. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/19523794/Project_DyAdd:_Fatty_acids_in_adult_dyslexia_ADHD_and_their_comorbid_combination_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(09)00058-1 DB - PRIME DP - Unbound Medicine ER -