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Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain.
Life Sci. 2009 Jul 31; 85(5-6):206-10.LS

Abstract

AIMS

It has been well documented that ventrolateral periaqueductal gray (vlPAG) matter is a crucial component of the descending pain modulatory system in the chronic pain condition. The aim of the present study was to identify the role of the vlPAG Nociceptin/Orphanin FQ/NOP receptor system in allodynia, a nociceptive behavioral response associated with chronic pain.

MAIN METHODS

We used two animal models of persistent pain: chronic constriction injury (CCI) and inflammation induced by carrageenan. In each, Nociceptin/Orphanin FQ transmission was abolished using UFP-101, a selective NOP receptor antagonist, which was injected into the vlPAG at a dose of 18 microg/1 microl/rat.

KEY FINDINGS

We found that treatment with the NOP antagonist reversed the decrease in allodynic threshold in CCI rats fourteen days after the ligature, which was the timepoint of the greatest reduction in threshold. Moreover, UFP-101 administered immediately prior to or 2 h after intra plantar (i.pl.) carrageenan injection prevented or reversed, respectively, allodynic behavior in rats with inflammation.

SIGNIFICANCE

Our findings support the hypothesis that the endogenous Nociceptin/Orphanin FQ/NOP receptor system is tonically active at the vlPAG level during neuropathic states or carrageenan inflammation.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, University of Catania, v.le A. Doria 6, 95125 Catania, Italy. scotog@unict.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19523963

Citation

Scoto, Giovanna M., et al. "Involvement of the Nociceptin/Orphanin FQ-NOP Receptor System in the Ventrolateral Periaqueductal Gray Following Mechanical Allodynia in Chronic Pain." Life Sciences, vol. 85, no. 5-6, 2009, pp. 206-10.
Scoto GM, Aricò G, Iemolo A, et al. Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain. Life Sci. 2009;85(5-6):206-10.
Scoto, G. M., Aricò, G., Iemolo, A., Ronsisvalle, S., & Parenti, C. (2009). Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain. Life Sciences, 85(5-6), 206-10. https://doi.org/10.1016/j.lfs.2009.05.021
Scoto GM, et al. Involvement of the Nociceptin/Orphanin FQ-NOP Receptor System in the Ventrolateral Periaqueductal Gray Following Mechanical Allodynia in Chronic Pain. Life Sci. 2009 Jul 31;85(5-6):206-10. PubMed PMID: 19523963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain. AU - Scoto,Giovanna M, AU - Aricò,Giuseppina, AU - Iemolo,Attilio, AU - Ronsisvalle,Simone, AU - Parenti,Carmela, Y1 - 2009/06/11/ PY - 2009/02/18/received PY - 2009/04/28/revised PY - 2009/05/21/accepted PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2009/7/31/medline SP - 206 EP - 10 JF - Life sciences JO - Life Sci. VL - 85 IS - 5-6 N2 - AIMS: It has been well documented that ventrolateral periaqueductal gray (vlPAG) matter is a crucial component of the descending pain modulatory system in the chronic pain condition. The aim of the present study was to identify the role of the vlPAG Nociceptin/Orphanin FQ/NOP receptor system in allodynia, a nociceptive behavioral response associated with chronic pain. MAIN METHODS: We used two animal models of persistent pain: chronic constriction injury (CCI) and inflammation induced by carrageenan. In each, Nociceptin/Orphanin FQ transmission was abolished using UFP-101, a selective NOP receptor antagonist, which was injected into the vlPAG at a dose of 18 microg/1 microl/rat. KEY FINDINGS: We found that treatment with the NOP antagonist reversed the decrease in allodynic threshold in CCI rats fourteen days after the ligature, which was the timepoint of the greatest reduction in threshold. Moreover, UFP-101 administered immediately prior to or 2 h after intra plantar (i.pl.) carrageenan injection prevented or reversed, respectively, allodynic behavior in rats with inflammation. SIGNIFICANCE: Our findings support the hypothesis that the endogenous Nociceptin/Orphanin FQ/NOP receptor system is tonically active at the vlPAG level during neuropathic states or carrageenan inflammation. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/19523963/Involvement_of_the_Nociceptin/Orphanin_FQ_NOP_receptor_system_in_the_ventrolateral_periaqueductal_gray_following_mechanical_allodynia_in_chronic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(09)00254-9 DB - PRIME DP - Unbound Medicine ER -