Tags

Type your tag names separated by a space and hit enter

Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation.
Hum Immunol 2009; 70(9):701-5HI

Abstract

In the present study, we investigated subpopulations of natural killer (NK) cells and the expression of stimulatory and inhibitory NK receptors after adult blood and bone marrow transplantation (BBMT) and cord blood transplantation (CBT). There were significant increases in CD16(+)CD56(dim) cell proportion and in absolute number in peripheral blood mononuclear cells (PBMC) during a period of 4-9 months after CBT compared with these in normal PBMC, cord blood (CB), and in PBMC after BBMT. Also, increased numbers of CD16(+)CD56(dim) NK cells were sustained in some patients until 4 years after CBT. This CD16(+)CD56(dim) cell subset after CBT exhibited decreased expression of NKG2A compared with that in CB and increased expression of NKG2C. Purified CD16(+)CD56(dim) cells from patients 8-9 months after CBT exhibited significantly higher levels of cytolytic activity against K562 than did purified CD16(+)CD56(bright) cells and also whole PBMC. The CD16(+)CD56(dim) cell subset with a high level of cytolytic activity significantly increased after CBT, and these cells may be responsible for NK cell-mediated immunity after CBT.

Authors+Show Affiliations

Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. jutanaka@med.hokudai.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19524005

Citation

Tanaka, Junji, et al. "Increased Number of CD16(+)CD56(dim) NK Cells in Peripheral Blood Mononuclear Cells After Allogeneic Cord Blood Transplantation." Human Immunology, vol. 70, no. 9, 2009, pp. 701-5.
Tanaka J, Sugita J, Asanuma S, et al. Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation. Hum Immunol. 2009;70(9):701-5.
Tanaka, J., Sugita, J., Asanuma, S., Arita, K., Shono, Y., Kikutchi, M., ... Imamura, M. (2009). Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation. Human Immunology, 70(9), pp. 701-5. doi:10.1016/j.humimm.2009.06.002.
Tanaka J, et al. Increased Number of CD16(+)CD56(dim) NK Cells in Peripheral Blood Mononuclear Cells After Allogeneic Cord Blood Transplantation. Hum Immunol. 2009;70(9):701-5. PubMed PMID: 19524005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation. AU - Tanaka,Junji, AU - Sugita,Junichi, AU - Asanuma,Shinsuke, AU - Arita,Kotaro, AU - Shono,Yusuke, AU - Kikutchi,Misato, AU - Shiratori,Souichi, AU - Wakasa,Kentaro, AU - Yasumoto,Atsushi, AU - Shigematu,Akio, AU - Kondo,Takeshi, AU - Kobayashi,Takahiko, AU - Asaka,Masahiro, AU - Imamura,Masahiro, Y1 - 2009/06/11/ PY - 2009/04/08/received PY - 2009/06/03/revised PY - 2009/06/03/accepted PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2010/2/2/medline SP - 701 EP - 5 JF - Human immunology JO - Hum. Immunol. VL - 70 IS - 9 N2 - In the present study, we investigated subpopulations of natural killer (NK) cells and the expression of stimulatory and inhibitory NK receptors after adult blood and bone marrow transplantation (BBMT) and cord blood transplantation (CBT). There were significant increases in CD16(+)CD56(dim) cell proportion and in absolute number in peripheral blood mononuclear cells (PBMC) during a period of 4-9 months after CBT compared with these in normal PBMC, cord blood (CB), and in PBMC after BBMT. Also, increased numbers of CD16(+)CD56(dim) NK cells were sustained in some patients until 4 years after CBT. This CD16(+)CD56(dim) cell subset after CBT exhibited decreased expression of NKG2A compared with that in CB and increased expression of NKG2C. Purified CD16(+)CD56(dim) cells from patients 8-9 months after CBT exhibited significantly higher levels of cytolytic activity against K562 than did purified CD16(+)CD56(bright) cells and also whole PBMC. The CD16(+)CD56(dim) cell subset with a high level of cytolytic activity significantly increased after CBT, and these cells may be responsible for NK cell-mediated immunity after CBT. SN - 1879-1166 UR - https://www.unboundmedicine.com/medline/citation/19524005/Increased_number_of_CD16_+_CD56_dim__NK_cells_in_peripheral_blood_mononuclear_cells_after_allogeneic_cord_blood_transplantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0198-8859(09)00142-6 DB - PRIME DP - Unbound Medicine ER -