Tags

Type your tag names separated by a space and hit enter

Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task.
Neurobiol Learn Mem. 2009 Nov; 92(4):597-601.NL

Abstract

It is well established that genetic deletion or pharmacological inhibition of the CB(1) receptor disrupts extinction learning in aversive conditioning tasks, but not in appetitive tasks. Consistent with these findings is that genetic deletion or pharmacological inhibition of fatty acid amide hydrolase (FAAH), the primary catabolic enzyme of the endogenous cannabinoid anandamide (AEA), accelerates acquisition as well as extinction in aversive conditioning tasks. However, it is unknown whether FAAH blockade will affect acquisition in an appetitive conditioning task. Therefore, in the present study, we assessed FAAH (-/-) and (+/+) mice in appetitive and aversive Barnes maze conditioning procedures. Here we report that FAAH (-/-) mice displayed accelerated acquisition rates in an aversively-motivated, but not in the appetitively-motivated, Barnes maze task. The CB(1) receptor antagonist, rimonabant attenuated enhanced acquisition in the aversive procedure, consistent with the idea that elevated AEA levels mediate this apparent nootropic effect. These findings support the hypothesis that stimulation of the endocannabinoid system enhances learned behavior in aversive, but not appetitive, conditioning paradigms.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0613, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19524055

Citation

Wise, Laura E., et al. "Fatty Acid Amide Hydrolase (FAAH) Knockout Mice Exhibit Enhanced Acquisition of an Aversive, but Not of an Appetitive, Barnes Maze Task." Neurobiology of Learning and Memory, vol. 92, no. 4, 2009, pp. 597-601.
Wise LE, Harloe JP, Lichtman AH. Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task. Neurobiol Learn Mem. 2009;92(4):597-601.
Wise, L. E., Harloe, J. P., & Lichtman, A. H. (2009). Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task. Neurobiology of Learning and Memory, 92(4), 597-601. https://doi.org/10.1016/j.nlm.2009.06.001
Wise LE, Harloe JP, Lichtman AH. Fatty Acid Amide Hydrolase (FAAH) Knockout Mice Exhibit Enhanced Acquisition of an Aversive, but Not of an Appetitive, Barnes Maze Task. Neurobiol Learn Mem. 2009;92(4):597-601. PubMed PMID: 19524055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task. AU - Wise,Laura E, AU - Harloe,John P, AU - Lichtman,Aron H, Y1 - 2009/06/11/ PY - 2009/03/26/received PY - 2009/05/10/revised PY - 2009/06/07/accepted PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2009/12/16/medline SP - 597 EP - 601 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 92 IS - 4 N2 - It is well established that genetic deletion or pharmacological inhibition of the CB(1) receptor disrupts extinction learning in aversive conditioning tasks, but not in appetitive tasks. Consistent with these findings is that genetic deletion or pharmacological inhibition of fatty acid amide hydrolase (FAAH), the primary catabolic enzyme of the endogenous cannabinoid anandamide (AEA), accelerates acquisition as well as extinction in aversive conditioning tasks. However, it is unknown whether FAAH blockade will affect acquisition in an appetitive conditioning task. Therefore, in the present study, we assessed FAAH (-/-) and (+/+) mice in appetitive and aversive Barnes maze conditioning procedures. Here we report that FAAH (-/-) mice displayed accelerated acquisition rates in an aversively-motivated, but not in the appetitively-motivated, Barnes maze task. The CB(1) receptor antagonist, rimonabant attenuated enhanced acquisition in the aversive procedure, consistent with the idea that elevated AEA levels mediate this apparent nootropic effect. These findings support the hypothesis that stimulation of the endocannabinoid system enhances learned behavior in aversive, but not appetitive, conditioning paradigms. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/19524055/Fatty_acid_amide_hydrolase__FAAH__knockout_mice_exhibit_enhanced_acquisition_of_an_aversive_but_not_of_an_appetitive_Barnes_maze_task_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(09)00127-0 DB - PRIME DP - Unbound Medicine ER -