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Local salsolinol modulates dopamine extracellular levels from rat nucleus accumbens: shell/core differences.
Neurochem Int. 2009 Sep; 55(4):187-92.NI

Abstract

Salsolinol (SAL), a condensation product of dopamine and acetaldehyde that appears in the rat and human brain after ethanol ingestion, has been largely implicated in the aetiology of alcoholism. Although the behavioural consequences of systemic or intracerebral SAL administrations have been described, the neurochemical effects of pharmacologically relevant doses of SAL and other tetrahydroisoquinolines (THIQs) in the brain areas involved in alcohol addiction are practically unknown. To gain an insight into this topic, male Wistar rats were stereotaxically implanted with one concentric microdialysis probe in either the shell or the core of the nucleus accumbens (NAc). Treatments involved local administration of 0.1, 5 and 25 microM SAL for 20 min through the dialysis probe. Dopamine (DA) concentrations in the shell or core of the NAc were on-line analyzed every 20 min by HPLC with electrochemical detection. Implantation of the probe was histologically evaluated at the end of the experiments. Our results indicate that dialysis application of 5 and 25 microM SAL into the core increased the dialysate levels of DA. Conversely, the administration of the same doses of this drug into the shell significantly reduced the DA levels in this subregion. In conclusion, these data reveal that local application of SAL affects the DA levels in the NAc subterritories in a region-specific manner. These findings may prove useful in probing CNS sites and mechanisms involved in alcohol consumption.

Authors+Show Affiliations

Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Valencia, Avda Vicente Andrés Estellés s/n, 46100 Burjassot, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19524107

Citation

Hipólito, Lucía, et al. "Local Salsolinol Modulates Dopamine Extracellular Levels From Rat Nucleus Accumbens: Shell/core Differences." Neurochemistry International, vol. 55, no. 4, 2009, pp. 187-92.
Hipólito L, Sánchez-Catalán MJ, Granero L, et al. Local salsolinol modulates dopamine extracellular levels from rat nucleus accumbens: shell/core differences. Neurochem Int. 2009;55(4):187-92.
Hipólito, L., Sánchez-Catalán, M. J., Granero, L., & Polache, A. (2009). Local salsolinol modulates dopamine extracellular levels from rat nucleus accumbens: shell/core differences. Neurochemistry International, 55(4), 187-92. https://doi.org/10.1016/j.neuint.2009.02.014
Hipólito L, et al. Local Salsolinol Modulates Dopamine Extracellular Levels From Rat Nucleus Accumbens: Shell/core Differences. Neurochem Int. 2009;55(4):187-92. PubMed PMID: 19524107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local salsolinol modulates dopamine extracellular levels from rat nucleus accumbens: shell/core differences. AU - Hipólito,Lucía, AU - Sánchez-Catalán,María José, AU - Granero,Luis, AU - Polache,Ana, Y1 - 2009/03/05/ PY - 2008/12/23/received PY - 2009/02/17/revised PY - 2009/02/25/accepted PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2009/9/3/medline SP - 187 EP - 92 JF - Neurochemistry international JO - Neurochem Int VL - 55 IS - 4 N2 - Salsolinol (SAL), a condensation product of dopamine and acetaldehyde that appears in the rat and human brain after ethanol ingestion, has been largely implicated in the aetiology of alcoholism. Although the behavioural consequences of systemic or intracerebral SAL administrations have been described, the neurochemical effects of pharmacologically relevant doses of SAL and other tetrahydroisoquinolines (THIQs) in the brain areas involved in alcohol addiction are practically unknown. To gain an insight into this topic, male Wistar rats were stereotaxically implanted with one concentric microdialysis probe in either the shell or the core of the nucleus accumbens (NAc). Treatments involved local administration of 0.1, 5 and 25 microM SAL for 20 min through the dialysis probe. Dopamine (DA) concentrations in the shell or core of the NAc were on-line analyzed every 20 min by HPLC with electrochemical detection. Implantation of the probe was histologically evaluated at the end of the experiments. Our results indicate that dialysis application of 5 and 25 microM SAL into the core increased the dialysate levels of DA. Conversely, the administration of the same doses of this drug into the shell significantly reduced the DA levels in this subregion. In conclusion, these data reveal that local application of SAL affects the DA levels in the NAc subterritories in a region-specific manner. These findings may prove useful in probing CNS sites and mechanisms involved in alcohol consumption. SN - 1872-9754 UR - https://www.unboundmedicine.com/medline/citation/19524107/Local_salsolinol_modulates_dopamine_extracellular_levels_from_rat_nucleus_accumbens:_shell/core_differences_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-0186(09)00081-3 DB - PRIME DP - Unbound Medicine ER -