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Neuroprotective effect of methanol extract of Phellodendri Cortex against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells.
Cell Biol Int. 2009 Sep; 33(9):957-63.CB

Abstract

Phellodendri Cortex (PC) is a traditional herbal medicine, widely used in Korea and China. The effects of the methanol extract of Phellodendri Cortex (PC extract) on 1-methyl-4-phenylpyridinium (MPP(+))-induced neuronal apoptosis in PC-12 cells have been investigated. MPP(+)-induced apoptosis in PC-12 cells was accompanied by an increased bax/bcl-2 ratio, release of cytochrome c to the cytosol and activation of caspase-3. PC extract inhibited the downregulation of bcl-2 and the upregulation of bax, as well as the release of mitochondrial cytochrome c into the cytosol. In addition, PC extract attenuated caspase-3 activation and cleavage of poly (ADP-ribose) polymerase (PARP). These results suggest that the PC extract has protective effects against MPP(+)-induced neuronal apoptosis in PC-12 cells.

Authors+Show Affiliations

Department of Herbology, College of Oriental Medicine, Dongguk University, Gyeongju 780-714. Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19524685

Citation

Jung, Hyo Won, et al. "Neuroprotective Effect of Methanol Extract of Phellodendri Cortex Against 1-methyl-4-phenylpyridinium (MPP+)-induced Apoptosis in PC-12 Cells." Cell Biology International, vol. 33, no. 9, 2009, pp. 957-63.
Jung HW, Jin GZ, Kim SY, et al. Neuroprotective effect of methanol extract of Phellodendri Cortex against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells. Cell Biol Int. 2009;33(9):957-63.
Jung, H. W., Jin, G. Z., Kim, S. Y., Kim, Y. S., & Park, Y. K. (2009). Neuroprotective effect of methanol extract of Phellodendri Cortex against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells. Cell Biology International, 33(9), 957-63. https://doi.org/10.1016/j.cellbi.2009.06.006
Jung HW, et al. Neuroprotective Effect of Methanol Extract of Phellodendri Cortex Against 1-methyl-4-phenylpyridinium (MPP+)-induced Apoptosis in PC-12 Cells. Cell Biol Int. 2009;33(9):957-63. PubMed PMID: 19524685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effect of methanol extract of Phellodendri Cortex against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells. AU - Jung,Hyo Won, AU - Jin,Guang-Zhen, AU - Kim,Sung Yun, AU - Kim,Yeong Shik, AU - Park,Yong-Ki, Y1 - 2009/06/12/ PY - 2008/10/15/received PY - 2009/04/14/revised PY - 2009/06/03/accepted PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2009/12/16/medline SP - 957 EP - 63 JF - Cell biology international JO - Cell Biol Int VL - 33 IS - 9 N2 - Phellodendri Cortex (PC) is a traditional herbal medicine, widely used in Korea and China. The effects of the methanol extract of Phellodendri Cortex (PC extract) on 1-methyl-4-phenylpyridinium (MPP(+))-induced neuronal apoptosis in PC-12 cells have been investigated. MPP(+)-induced apoptosis in PC-12 cells was accompanied by an increased bax/bcl-2 ratio, release of cytochrome c to the cytosol and activation of caspase-3. PC extract inhibited the downregulation of bcl-2 and the upregulation of bax, as well as the release of mitochondrial cytochrome c into the cytosol. In addition, PC extract attenuated caspase-3 activation and cleavage of poly (ADP-ribose) polymerase (PARP). These results suggest that the PC extract has protective effects against MPP(+)-induced neuronal apoptosis in PC-12 cells. SN - 1095-8355 UR - https://www.unboundmedicine.com/medline/citation/19524685/Neuroprotective_effect_of_methanol_extract_of_Phellodendri_Cortex_against_1_methyl_4_phenylpyridinium__MPP+__induced_apoptosis_in_PC_12_cells_ L2 - https://doi.org/10.1016/j.cellbi.2009.06.006 DB - PRIME DP - Unbound Medicine ER -