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URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats.
Can J Physiol Pharmacol. 2009 Jun; 87(6):432-9.CJ

Abstract

Diabetic rats display increased pain responses after injection of formalin into the paw or thermal stimulation of the tail, suggesting the presence of hyperalgesia. In this study, we investigated the efficacy of URB597 (0.1, 0.3, and 0.5 mg/kg, i.p.), an inhibitor of endocannabinoids metabolism, on 2 models of experimental hyperalgesia in streptozotocin (STZ)-induced diabetic rats. Animals were divided into control, URB597-treated control (0.1, 0.3, and 0.5 mg/kg), diabetic, and URB597-treated diabetic (0.1, 0.3, and 0.5 mg/kg) groups. Formalin and tail-flick tests were performed 4 and 8 weeks after the onset of hyperglycemia, respectively. Diabetes caused significant hyperalgesia during these tests. URB597 (0.3 and 0.5 mg/kg) reversed chemical and thermal hyperalgesia in diabetic rats. Administration of URB597 at a dose of 0.1 mg/kg did not alter pain-related behaviors in control and diabetic groups compared with those of the respective control groups. URB597 treatment did not affect body weight or plasma glucose level of treated animals compared with nontreated animals. This study shows that increasing endocannabinoid neurotransmission with URB597 displays efficacy in chemical and thermal models of diabetic hyperalgesia. It also suggests that URB597 is a promising tool for treatment of painful diabetic neuropathy.

Authors+Show Affiliations

Department of Biology, School of Basic Sciences, Bu-Ali Sina University, Hamadan 65178-33391, Iran. p.hasanein@basu.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19526037

Citation

Hasanein, Parisa, et al. "URB597, an Inhibitor of Fatty Acid Amide Hydrolase, Reduces Hyperalgesia in Diabetic Rats." Canadian Journal of Physiology and Pharmacology, vol. 87, no. 6, 2009, pp. 432-9.
Hasanein P, Parviz M, Keshavarz M, et al. URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats. Can J Physiol Pharmacol. 2009;87(6):432-9.
Hasanein, P., Parviz, M., Keshavarz, M., & Roohbakhsh, A. (2009). URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats. Canadian Journal of Physiology and Pharmacology, 87(6), 432-9. https://doi.org/10.1139/y09-026
Hasanein P, et al. URB597, an Inhibitor of Fatty Acid Amide Hydrolase, Reduces Hyperalgesia in Diabetic Rats. Can J Physiol Pharmacol. 2009;87(6):432-9. PubMed PMID: 19526037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats. AU - Hasanein,Parisa, AU - Parviz,Mohsen, AU - Keshavarz,Mansoor, AU - Roohbakhsh,Ali, PY - 2009/6/16/entrez PY - 2009/6/16/pubmed PY - 2010/1/29/medline SP - 432 EP - 9 JF - Canadian journal of physiology and pharmacology JO - Can. J. Physiol. Pharmacol. VL - 87 IS - 6 N2 - Diabetic rats display increased pain responses after injection of formalin into the paw or thermal stimulation of the tail, suggesting the presence of hyperalgesia. In this study, we investigated the efficacy of URB597 (0.1, 0.3, and 0.5 mg/kg, i.p.), an inhibitor of endocannabinoids metabolism, on 2 models of experimental hyperalgesia in streptozotocin (STZ)-induced diabetic rats. Animals were divided into control, URB597-treated control (0.1, 0.3, and 0.5 mg/kg), diabetic, and URB597-treated diabetic (0.1, 0.3, and 0.5 mg/kg) groups. Formalin and tail-flick tests were performed 4 and 8 weeks after the onset of hyperglycemia, respectively. Diabetes caused significant hyperalgesia during these tests. URB597 (0.3 and 0.5 mg/kg) reversed chemical and thermal hyperalgesia in diabetic rats. Administration of URB597 at a dose of 0.1 mg/kg did not alter pain-related behaviors in control and diabetic groups compared with those of the respective control groups. URB597 treatment did not affect body weight or plasma glucose level of treated animals compared with nontreated animals. This study shows that increasing endocannabinoid neurotransmission with URB597 displays efficacy in chemical and thermal models of diabetic hyperalgesia. It also suggests that URB597 is a promising tool for treatment of painful diabetic neuropathy. SN - 1205-7541 UR - https://www.unboundmedicine.com/medline/citation/19526037/URB597_an_inhibitor_of_fatty_acid_amide_hydrolase_reduces_hyperalgesia_in_diabetic_rats_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/y09-026?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -