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[Influence of electroacupuncture of "Baihui" (GV 20) and "Sanyinjiao" (SP 6) on hippocampal 5-HT and AChE immuno-activity in chronic depression rats].
Zhen Ci Yan Jiu. 2009 Feb; 34(1):16-20.ZC

Abstract

OBJECTIVE

To investigate the influence of electroacupuncture (EA) on 5-serotonin (5-HT) and acetyl cholinesterase (AChE) activities in hippocampus tissue in chronic stressed-induced depression rats.

METHODS

Thirty-two Wistar rats were randomized into normal control group (n=10), model group (n=11) and EA group (n=11). Chronic depression model was established by lonely raising, and chronic unpredictable mild stress for 21 days. EA (2 Hz, 1 mA) was applied to "Baihui" (GV 20) and "Sanyinjiao" (SP 6) for 20 minutes, once daily for 14 days. 5-HT and AChE expression of hippocampal CA 4 region was detected by using immunohistochemistry, and their integrated optical density (IOD) values were determined by using image analysis system.

RESULTS

Compared with normal control group, IOD values of 5-HT and AChE immuno-reaction (IR) positive neurons in hippocampal CA 4 region of model group decreased significantly (P<0.05). In comparison with model group, the IOD values of 5-HT and AChE IR positive neurons of CA 4 region in EA group increased significantly (P<0.05). No significant differences were found between EA and normal control groups in IOD values of both 5-HT and AChE IR positive neurons.

CONCLUSION

EA can upregulate 5-HT and AChE expression in hippocampal CA 4 region in depression rats, which may contribute to its effect in relieving depression.

Authors+Show Affiliations

College of Chinese Medicine, Chongqing Medical University, Chongqing 401331, China. zyzy_178@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19526802

Citation

Zhu, Yi, et al. "[Influence of Electroacupuncture of "Baihui" (GV 20) and "Sanyinjiao" (SP 6) On Hippocampal 5-HT and AChE Immuno-activity in Chronic Depression Rats]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 34, no. 1, 2009, pp. 16-20.
Zhu Y, Liu QY, Zhuo LS. [Influence of electroacupuncture of "Baihui" (GV 20) and "Sanyinjiao" (SP 6) on hippocampal 5-HT and AChE immuno-activity in chronic depression rats]. Zhen Ci Yan Jiu. 2009;34(1):16-20.
Zhu, Y., Liu, Q. Y., & Zhuo, L. S. (2009). [Influence of electroacupuncture of "Baihui" (GV 20) and "Sanyinjiao" (SP 6) on hippocampal 5-HT and AChE immuno-activity in chronic depression rats]. Zhen Ci Yan Jiu = Acupuncture Research, 34(1), 16-20.
Zhu Y, Liu QY, Zhuo LS. [Influence of Electroacupuncture of "Baihui" (GV 20) and "Sanyinjiao" (SP 6) On Hippocampal 5-HT and AChE Immuno-activity in Chronic Depression Rats]. Zhen Ci Yan Jiu. 2009;34(1):16-20. PubMed PMID: 19526802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influence of electroacupuncture of "Baihui" (GV 20) and "Sanyinjiao" (SP 6) on hippocampal 5-HT and AChE immuno-activity in chronic depression rats]. AU - Zhu,Yi, AU - Liu,Qun-ying, AU - Zhuo,Lian-shi, PY - 2009/6/17/entrez PY - 2009/6/17/pubmed PY - 2009/7/10/medline SP - 16 EP - 20 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 34 IS - 1 N2 - OBJECTIVE: To investigate the influence of electroacupuncture (EA) on 5-serotonin (5-HT) and acetyl cholinesterase (AChE) activities in hippocampus tissue in chronic stressed-induced depression rats. METHODS: Thirty-two Wistar rats were randomized into normal control group (n=10), model group (n=11) and EA group (n=11). Chronic depression model was established by lonely raising, and chronic unpredictable mild stress for 21 days. EA (2 Hz, 1 mA) was applied to "Baihui" (GV 20) and "Sanyinjiao" (SP 6) for 20 minutes, once daily for 14 days. 5-HT and AChE expression of hippocampal CA 4 region was detected by using immunohistochemistry, and their integrated optical density (IOD) values were determined by using image analysis system. RESULTS: Compared with normal control group, IOD values of 5-HT and AChE immuno-reaction (IR) positive neurons in hippocampal CA 4 region of model group decreased significantly (P<0.05). In comparison with model group, the IOD values of 5-HT and AChE IR positive neurons of CA 4 region in EA group increased significantly (P<0.05). No significant differences were found between EA and normal control groups in IOD values of both 5-HT and AChE IR positive neurons. CONCLUSION: EA can upregulate 5-HT and AChE expression in hippocampal CA 4 region in depression rats, which may contribute to its effect in relieving depression. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/19526802/[Influence_of_electroacupuncture_of_"Baihui"__GV_20__and_"Sanyinjiao"__SP_6__on_hippocampal_5_HT_and_AChE_immuno_activity_in_chronic_depression_rats]_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -