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Androgenetic alopecia in males: a histopathological and ultrastructural study.
J Cosmet Dermatol. 2009 Jun; 8(2):83-91.JC

Abstract

BACKGROUND

Androgenetic alopecia is a common cosmetic hair disorder, resulting from interplay of genetic, endocrine, and aging factors leading to a patterned follicular miniaturization. Microinflammation seems to be a potential active player in this process.

AIMS

To study the histopathological and ultrastructural changes occurring in male androgenetic alopecia (AGA). Patients/methods Fifty-five subjects were included in this study (40 with AGA and 15 as normal age-matched controls). Skin biopsies from frontal bald area and occipital hairy area were subjected to histopathological examination, immunohistochemical staining for collagen I and ultrastructural study.

RESULTS

The frontal bald area of patients showed highly significant increase in telogen hairs and decrease in anagen/telogen ratio and terminal/vellus hair ratio (P < 0.001). Perifollicular inflammation was almost a constant feature in early cases and showed a significant inverse correlation with perifollicular fibrosis (P = 0.048), which was more marked with thickening of the follicular sheath in advanced cases.

CONCLUSION

Follicular microinflammation plays an integral role in the pathogenesis of AGA in early cases. Over time, thickening of perifollicular sheath takes place due to increased deposition of collagen, resulting in marked perifollicular fibrosis, and sometimes ends by complete destruction of the affected follicles in advanced cases.

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Authors+Show Affiliations

El-Domyati M
Department of Dermatology, Al-Minya University, 2 Obour Buildings, Salah Salem St, Apt. 53, Nasr City, Cairo 11371, Egypt. moetazeldomyati@yahoo.com
Attia S
No affiliation info available
Saleh F
No affiliation info available
Abdel-Wahab H
No affiliation info available

MeSH

AdultAge FactorsAgedAlopeciaBiopsyCase-Control StudiesCollagenFibrosisHair FollicleHumansMaleMiddle AgedPredictive Value of TestsRisk FactorsScalpSeverity of Illness IndexSex Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19527330

Citation

El-Domyati, Moetaz, et al. "Androgenetic Alopecia in Males: a Histopathological and Ultrastructural Study." Journal of Cosmetic Dermatology, vol. 8, no. 2, 2009, pp. 83-91.
El-Domyati M, Attia S, Saleh F, et al. Androgenetic alopecia in males: a histopathological and ultrastructural study. J Cosmet Dermatol. 2009;8(2):83-91.
El-Domyati, M., Attia, S., Saleh, F., & Abdel-Wahab, H. (2009). Androgenetic alopecia in males: a histopathological and ultrastructural study. Journal of Cosmetic Dermatology, 8(2), 83-91. https://doi.org/10.1111/j.1473-2165.2009.00439.x
El-Domyati M, et al. Androgenetic Alopecia in Males: a Histopathological and Ultrastructural Study. J Cosmet Dermatol. 2009;8(2):83-91. PubMed PMID: 19527330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgenetic alopecia in males: a histopathological and ultrastructural study. AU - El-Domyati,Moetaz, AU - Attia,Sameh, AU - Saleh,Fatma, AU - Abdel-Wahab,Hossam, PY - 2009/6/17/entrez PY - 2009/6/17/pubmed PY - 2009/11/17/medline SP - 83 EP - 91 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 8 IS - 2 N2 - BACKGROUND: Androgenetic alopecia is a common cosmetic hair disorder, resulting from interplay of genetic, endocrine, and aging factors leading to a patterned follicular miniaturization. Microinflammation seems to be a potential active player in this process. AIMS: To study the histopathological and ultrastructural changes occurring in male androgenetic alopecia (AGA). Patients/methods Fifty-five subjects were included in this study (40 with AGA and 15 as normal age-matched controls). Skin biopsies from frontal bald area and occipital hairy area were subjected to histopathological examination, immunohistochemical staining for collagen I and ultrastructural study. RESULTS: The frontal bald area of patients showed highly significant increase in telogen hairs and decrease in anagen/telogen ratio and terminal/vellus hair ratio (P < 0.001). Perifollicular inflammation was almost a constant feature in early cases and showed a significant inverse correlation with perifollicular fibrosis (P = 0.048), which was more marked with thickening of the follicular sheath in advanced cases. CONCLUSION: Follicular microinflammation plays an integral role in the pathogenesis of AGA in early cases. Over time, thickening of perifollicular sheath takes place due to increased deposition of collagen, resulting in marked perifollicular fibrosis, and sometimes ends by complete destruction of the affected follicles in advanced cases. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/19527330/Androgenetic_alopecia_in_males:_a_histopathological_and_ultrastructural_study_ L2 - https://doi.org/10.1111/j.1473-2165.2009.00439.x DB - PRIME DP - Unbound Medicine ER -