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MMN elicitation during natural sleep to violations of an auditory pattern.
Brain Res. 2009 Sep 22; 1290:52-62.BR

Abstract

The mismatch negativity (MMN) ERP component is generally considered to reflect the outcome of a pre-conscious change detection mechanism. The manipulation of active task demands has typically demonstrated that the MMN operates relatively independently of inferred attention. It remains a possibility, however, that subjects are capable of covertly sampling, or "eavesdropping" on, the irrelevant auditory stimuli, even during the most demanding of diversion tasks. The presence of the MMN in an unconscious state, such as natural sleep, provides strong evidence that its operations take place at a pre-conscious level. There exists consistent evidence that the MMN can be elicited at least during REM sleep, but these MMNs were typically elicited using oddball paradigms in which the new physical properties of deviants may trigger fresh afferent activation. The current sleep study employed a standard pattern in which two pure tones alternated (e.g. ABABABAB). Deviants were repetitions (e.g., ABABBBAB), and therefore physically identical to the preceding standard. In different conditions, the tones of the pattern were separated by either 1 or 6 semitones. A clear MMN was elicited in the waking state in the 6 semitone condition. The MMN was also elicited in the 6 semitone condition during REM sleep. No MMN was apparent in REM sleep in the 1 semitone condition. The MMN was not apparent in either the 6 or 1 semitone condition during NREM sleep. These results confirm the operation of the MMN in REM sleep, and support the view that the MMN operates at a pre-conscious level of processing.

Authors+Show Affiliations

School of Psychology, University of Ottawa, Ontario, Canada K1N 6N5. lauren.sculthorpe@nrc.gc.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19527697

Citation

Sculthorpe, Lauren D., et al. "MMN Elicitation During Natural Sleep to Violations of an Auditory Pattern." Brain Research, vol. 1290, 2009, pp. 52-62.
Sculthorpe LD, Ouellet DR, Campbell KB. MMN elicitation during natural sleep to violations of an auditory pattern. Brain Res. 2009;1290:52-62.
Sculthorpe, L. D., Ouellet, D. R., & Campbell, K. B. (2009). MMN elicitation during natural sleep to violations of an auditory pattern. Brain Research, 1290, 52-62. https://doi.org/10.1016/j.brainres.2009.06.013
Sculthorpe LD, Ouellet DR, Campbell KB. MMN Elicitation During Natural Sleep to Violations of an Auditory Pattern. Brain Res. 2009 Sep 22;1290:52-62. PubMed PMID: 19527697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MMN elicitation during natural sleep to violations of an auditory pattern. AU - Sculthorpe,Lauren D, AU - Ouellet,Daniel R, AU - Campbell,Kenneth B, Y1 - 2009/06/13/ PY - 2009/01/27/received PY - 2009/06/05/revised PY - 2009/06/07/accepted PY - 2009/6/17/entrez PY - 2009/6/17/pubmed PY - 2009/10/17/medline SP - 52 EP - 62 JF - Brain research JO - Brain Res VL - 1290 N2 - The mismatch negativity (MMN) ERP component is generally considered to reflect the outcome of a pre-conscious change detection mechanism. The manipulation of active task demands has typically demonstrated that the MMN operates relatively independently of inferred attention. It remains a possibility, however, that subjects are capable of covertly sampling, or "eavesdropping" on, the irrelevant auditory stimuli, even during the most demanding of diversion tasks. The presence of the MMN in an unconscious state, such as natural sleep, provides strong evidence that its operations take place at a pre-conscious level. There exists consistent evidence that the MMN can be elicited at least during REM sleep, but these MMNs were typically elicited using oddball paradigms in which the new physical properties of deviants may trigger fresh afferent activation. The current sleep study employed a standard pattern in which two pure tones alternated (e.g. ABABABAB). Deviants were repetitions (e.g., ABABBBAB), and therefore physically identical to the preceding standard. In different conditions, the tones of the pattern were separated by either 1 or 6 semitones. A clear MMN was elicited in the waking state in the 6 semitone condition. The MMN was also elicited in the 6 semitone condition during REM sleep. No MMN was apparent in REM sleep in the 1 semitone condition. The MMN was not apparent in either the 6 or 1 semitone condition during NREM sleep. These results confirm the operation of the MMN in REM sleep, and support the view that the MMN operates at a pre-conscious level of processing. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/19527697/MMN_elicitation_during_natural_sleep_to_violations_of_an_auditory_pattern_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)01182-2 DB - PRIME DP - Unbound Medicine ER -