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[Prophylactic effect of allopurinol mouthwash against stomatitis induced by the chemotherapy (PMUE regimen) for gastrointestinal malignancies].
Gan To Kagaku Ryoho. 1991 Nov; 18(14):2463-6.GT

Abstract

For prevention of the chemotherapy-induced stomatitis we administered allopurinol mouthwash to 15 out of 38 patients who underwent PMUE regimen. The severity of stomatitis was graded on five scales according to the criteria of Japan Society For Cancer Therapy. The incidence of stomatitis was defined as patients number with stomatitis above Grade 2/all patients number. Six of 23 patients which were not given allopurinol mouthwash (control group) developed stomatitis of Grade 1 (three patients), Grade 3 (two), or Grade 4 (one). Only one patient given allopurinol mouthwash (AMW group), however, suffered from Grade 1 stomatitis. The incidence of stomatitis was 13.0% for a control group and 0% for an AMW group. The average graded toxicity was 0.07 for the AMW group significantly lower than 0.57 for the control group. There was no significant difference between the two groups in other clinical adverse effects or abnormal laboratory data. These results suggested that allopurinol mouthwash regimen was well tolerated and effective for prevention of the chemotherapy induced stomatitis.

Authors+Show Affiliations

Dept. of Surgery, Takaoka City Hospital, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

1952966

Citation

Fujimura, T, et al. "[Prophylactic Effect of Allopurinol Mouthwash Against Stomatitis Induced By the Chemotherapy (PMUE Regimen) for Gastrointestinal Malignancies]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 18, no. 14, 1991, pp. 2463-6.
Fujimura T, Shima Y, Sawasaki K, et al. [Prophylactic effect of allopurinol mouthwash against stomatitis induced by the chemotherapy (PMUE regimen) for gastrointestinal malignancies]. Gan To Kagaku Ryoho. 1991;18(14):2463-6.
Fujimura, T., Shima, Y., Sawasaki, K., Haryo, S., Fujita, H., Anada, E., & Shiota, S. (1991). [Prophylactic effect of allopurinol mouthwash against stomatitis induced by the chemotherapy (PMUE regimen) for gastrointestinal malignancies]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 18(14), 2463-6.
Fujimura T, et al. [Prophylactic Effect of Allopurinol Mouthwash Against Stomatitis Induced By the Chemotherapy (PMUE Regimen) for Gastrointestinal Malignancies]. Gan To Kagaku Ryoho. 1991;18(14):2463-6. PubMed PMID: 1952966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prophylactic effect of allopurinol mouthwash against stomatitis induced by the chemotherapy (PMUE regimen) for gastrointestinal malignancies]. AU - Fujimura,T, AU - Shima,Y, AU - Sawasaki,K, AU - Haryo,S, AU - Fujita,H, AU - Anada,E, AU - Shiota,S, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 2463 EP - 6 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 18 IS - 14 N2 - For prevention of the chemotherapy-induced stomatitis we administered allopurinol mouthwash to 15 out of 38 patients who underwent PMUE regimen. The severity of stomatitis was graded on five scales according to the criteria of Japan Society For Cancer Therapy. The incidence of stomatitis was defined as patients number with stomatitis above Grade 2/all patients number. Six of 23 patients which were not given allopurinol mouthwash (control group) developed stomatitis of Grade 1 (three patients), Grade 3 (two), or Grade 4 (one). Only one patient given allopurinol mouthwash (AMW group), however, suffered from Grade 1 stomatitis. The incidence of stomatitis was 13.0% for a control group and 0% for an AMW group. The average graded toxicity was 0.07 for the AMW group significantly lower than 0.57 for the control group. There was no significant difference between the two groups in other clinical adverse effects or abnormal laboratory data. These results suggested that allopurinol mouthwash regimen was well tolerated and effective for prevention of the chemotherapy induced stomatitis. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/1952966/[Prophylactic_effect_of_allopurinol_mouthwash_against_stomatitis_induced_by_the_chemotherapy__PMUE_regimen__for_gastrointestinal_malignancies]_ DB - PRIME DP - Unbound Medicine ER -