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Characterizing cardiovascular risk in women with polycystic ovary syndrome: more than the sum of its parts?
Semin Reprod Med. 2009 Jul; 27(4):299-305.SR

Abstract

Polycystic ovary syndrome (PCOS), a condition of irregular menses and androgen excess, is the most common endocrinopathy of young women. Insulin resistance is a well-established feature among many women with PCOS, even in the nonobese. Therefore, it is not surprising that PCOS is frequently associated with cardiovascular risk factors and the metabolic syndrome. However, it is not known whether PCOS is an independent risk factor for atherosclerosis and cardiovascular (CV) events or whether CV risk is attributable to associated risk factors. We review previous studies on CV risk and disease in women with PCOS, describing the pitfalls and challenges in ascribing CV risk to PCOS. Women with PCOS might be partly reassured that their relative risk approximates that of the metabolic syndrome (RR 1.5) and also strongly counseled at the individual level about the greatest potential threat to their CV health, the development of type 2 diabetes.

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Authors+Show Affiliations

Chang AY
Departments of Internal Medicine and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390-8857, USA. alice.chang@utsouthwestern.edu
Wild RA
No affiliation info available

MeSH

BiomarkersCardiovascular DiseasesCardiovascular Physiological PhenomenaFemaleHumansModels, BiologicalPolycystic Ovary SyndromePrevalenceRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19530063

Citation

Chang, Alice Y., and Robert A. Wild. "Characterizing Cardiovascular Risk in Women With Polycystic Ovary Syndrome: More Than the Sum of Its Parts?" Seminars in Reproductive Medicine, vol. 27, no. 4, 2009, pp. 299-305.
Chang AY, Wild RA. Characterizing cardiovascular risk in women with polycystic ovary syndrome: more than the sum of its parts? Semin Reprod Med. 2009;27(4):299-305.
Chang, A. Y., & Wild, R. A. (2009). Characterizing cardiovascular risk in women with polycystic ovary syndrome: more than the sum of its parts? Seminars in Reproductive Medicine, 27(4), 299-305. https://doi.org/10.1055/s-0029-1225257
Chang AY, Wild RA. Characterizing Cardiovascular Risk in Women With Polycystic Ovary Syndrome: More Than the Sum of Its Parts. Semin Reprod Med. 2009;27(4):299-305. PubMed PMID: 19530063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterizing cardiovascular risk in women with polycystic ovary syndrome: more than the sum of its parts? AU - Chang,Alice Y, AU - Wild,Robert A, Y1 - 2009/06/15/ PY - 2009/6/17/entrez PY - 2009/6/17/pubmed PY - 2009/8/26/medline SP - 299 EP - 305 JF - Seminars in reproductive medicine JO - Semin Reprod Med VL - 27 IS - 4 N2 - Polycystic ovary syndrome (PCOS), a condition of irregular menses and androgen excess, is the most common endocrinopathy of young women. Insulin resistance is a well-established feature among many women with PCOS, even in the nonobese. Therefore, it is not surprising that PCOS is frequently associated with cardiovascular risk factors and the metabolic syndrome. However, it is not known whether PCOS is an independent risk factor for atherosclerosis and cardiovascular (CV) events or whether CV risk is attributable to associated risk factors. We review previous studies on CV risk and disease in women with PCOS, describing the pitfalls and challenges in ascribing CV risk to PCOS. Women with PCOS might be partly reassured that their relative risk approximates that of the metabolic syndrome (RR 1.5) and also strongly counseled at the individual level about the greatest potential threat to their CV health, the development of type 2 diabetes. SN - 1526-4564 UR - https://www.unboundmedicine.com/medline/citation/19530063/Characterizing_cardiovascular_risk_in_women_with_polycystic_ovary_syndrome:_more_than_the_sum_of_its_parts L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1225257 DB - PRIME DP - Unbound Medicine ER -