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Serum uric acid is independently associated with metabolic syndrome in subjects with and without a low estimated glomerular filtration rate.
J Rheumatol. 2009 Aug; 36(8):1691-8.JR

Abstract

OBJECTIVE

The relationship among serum uric acid (SUA), metabolic syndrome, and chronic kidney disease (CKD) is unclear. We examined whether SUA level is an independent risk factor for chronic kidney disease and whether the association between SUA and metabolic syndrome is affected by kidney function.

METHODS

We analyzed 28,745 subjects (17,478 men, 11,267 women, age 20-49 yrs) who underwent health examinations at this hospital between 2000 and 2007. Hyperuricemia was defined as SUA level > 7.7 mg/dl in men or > 6.6 mg/dl in women. Kidney function was assessed by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study equation modified for Chinese subjects. Impaired renal function with low GFR was defined as eGFR < 90 ml/min/1.73 m(2). The UA-low GFR groups were defined according to the observed combination of hyperuricemia and low GFR: Group A (absence of both hyperuricemia and low GFR); Group B (presence of low GFR but no hyperuricemia); Group C (presence of hyperuricemia but not low GFR); and Group D (presence of both hyperuricemia and low GFR).

RESULTS

The prevalence of hyperuricemia, metabolic syndrome, and impaired kidney function with low GFR was 20.3% (27.6% in men, 8.9% in women), 7.6% (10.6% in men, 3.0% in women), and 9.9% (11.6% in men, 7.1% in women), respectively. The Pearson correlation between SUA and eGFR was only -0.26 (-0.21 in men, -0.22 in women; p < 0.001). In men, the age-adjusted odds ratio (OR) of metabolic syndrome was 1.41 (Group B), 2.45 (Group C), and 2.58 (Group D) in comparison with Group A. In women, the age-adjusted OR of metabolic syndrome was 0.83 (Group B), 5.47 (Group C), and 3.31 (Group D) in comparison with Group A.

CONCLUSION

Hyperuricemia is prevalent in the Taiwan population. Hyperuricemia is only weakly associated with renal function, but is strongly associated with metabolic syndrome with or without a low eGFR.

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Authors+Show Affiliations

See LC
Department of Public Health, BiostatisticsConsulting Center, Chang Gung University, Tao-Yuan, Taiwan, Republic of China.
Kuo CF
No affiliation info available
Chuang FH
No affiliation info available
Li HY
No affiliation info available
Chen YM
No affiliation info available
Chen HW
No affiliation info available
Yu KH
No affiliation info available

MeSH

AdultFemaleGlomerular Filtration RateHumansHyperuricemiaMaleMetabolic SyndromeMiddle AgedPrevalenceRegression AnalysisRenal Insufficiency, ChronicRisk FactorsTaiwanUric AcidYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19531754

Citation

See, Lai-Chu, et al. "Serum Uric Acid Is Independently Associated With Metabolic Syndrome in Subjects With and Without a Low Estimated Glomerular Filtration Rate." The Journal of Rheumatology, vol. 36, no. 8, 2009, pp. 1691-8.
See LC, Kuo CF, Chuang FH, et al. Serum uric acid is independently associated with metabolic syndrome in subjects with and without a low estimated glomerular filtration rate. J Rheumatol. 2009;36(8):1691-8.
See, L. C., Kuo, C. F., Chuang, F. H., Li, H. Y., Chen, Y. M., Chen, H. W., & Yu, K. H. (2009). Serum uric acid is independently associated with metabolic syndrome in subjects with and without a low estimated glomerular filtration rate. The Journal of Rheumatology, 36(8), 1691-8. https://doi.org/10.3899/jrheum.081199
See LC, et al. Serum Uric Acid Is Independently Associated With Metabolic Syndrome in Subjects With and Without a Low Estimated Glomerular Filtration Rate. J Rheumatol. 2009;36(8):1691-8. PubMed PMID: 19531754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid is independently associated with metabolic syndrome in subjects with and without a low estimated glomerular filtration rate. AU - See,Lai-Chu, AU - Kuo,Chang-Fu, AU - Chuang,Fang-Hsiu, AU - Li,Hong-Yi, AU - Chen,Yu-Ming, AU - Chen,Hung-Wei, AU - Yu,Kuang-Hui, Y1 - 2009/06/16/ PY - 2009/6/18/entrez PY - 2009/6/18/pubmed PY - 2009/10/9/medline SP - 1691 EP - 8 JF - The Journal of rheumatology JO - J Rheumatol VL - 36 IS - 8 N2 - OBJECTIVE: The relationship among serum uric acid (SUA), metabolic syndrome, and chronic kidney disease (CKD) is unclear. We examined whether SUA level is an independent risk factor for chronic kidney disease and whether the association between SUA and metabolic syndrome is affected by kidney function. METHODS: We analyzed 28,745 subjects (17,478 men, 11,267 women, age 20-49 yrs) who underwent health examinations at this hospital between 2000 and 2007. Hyperuricemia was defined as SUA level > 7.7 mg/dl in men or > 6.6 mg/dl in women. Kidney function was assessed by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study equation modified for Chinese subjects. Impaired renal function with low GFR was defined as eGFR < 90 ml/min/1.73 m(2). The UA-low GFR groups were defined according to the observed combination of hyperuricemia and low GFR: Group A (absence of both hyperuricemia and low GFR); Group B (presence of low GFR but no hyperuricemia); Group C (presence of hyperuricemia but not low GFR); and Group D (presence of both hyperuricemia and low GFR). RESULTS: The prevalence of hyperuricemia, metabolic syndrome, and impaired kidney function with low GFR was 20.3% (27.6% in men, 8.9% in women), 7.6% (10.6% in men, 3.0% in women), and 9.9% (11.6% in men, 7.1% in women), respectively. The Pearson correlation between SUA and eGFR was only -0.26 (-0.21 in men, -0.22 in women; p < 0.001). In men, the age-adjusted odds ratio (OR) of metabolic syndrome was 1.41 (Group B), 2.45 (Group C), and 2.58 (Group D) in comparison with Group A. In women, the age-adjusted OR of metabolic syndrome was 0.83 (Group B), 5.47 (Group C), and 3.31 (Group D) in comparison with Group A. CONCLUSION: Hyperuricemia is prevalent in the Taiwan population. Hyperuricemia is only weakly associated with renal function, but is strongly associated with metabolic syndrome with or without a low eGFR. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/19531754/Serum_uric_acid_is_independently_associated_with_metabolic_syndrome_in_subjects_with_and_without_a_low_estimated_glomerular_filtration_rate_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=19531754 DB - PRIME DP - Unbound Medicine ER -