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Serum visfatin in Asian women with polycystic ovary syndrome.
Gynecol Endocrinol 2009; 25(8):536-42GE

Abstract

OBJECTIVE

To determine serum visfatin levels in Asian polycystic ovary syndrome (PCOS) women and its correlations with various parameters.

STUDY DESIGN

Case-control study.

SETTING

University hospital.

SUBJECTS

Eighty women were enrolled in this study. Of these, 40 women were PCOS and 40 age-matched subjects with regular menstrual cycles were controls.

INTERVENTION

Seventy-five gram oral glucose tolerance tests were performed in all women. Fasting venous blood samples for serum visfatin, insulin and androgen levels were obtained both from the PCOS and the control women.

MAIN OUTCOME MEASURES

Serum concentrations of visfatin, fasting insulin (FI), fasting glucose, 2-h post-load glucose (2hPG), homeostasis model assessment insulin resistance, homeostasis model assessment beta cell function, total testosterone, free testosterone, androstenedione and dehydroepiandrosterone sulfate were measured in both groups.

RESULTS

Women with PCOS had significantly higher serum visfatin levels than the healthy controls [100.39 +/- 41.90 vs. 45.09 +/- 28.24 mg/ml, p < 0.01]. PCOS women also had significantly higher concentrations of all androgens (p < 0.01). Insulin resistance seemed to be greater in the PCOS than the control groups, but did not reach a statistically significant level. In the PCOS group, serum visfatin levels were positively correlated with 2hPG, and systolic blood pressure and diastolic blood pressure. Serum visfatin levels were negatively associated with FI (r = -0.80, p = 0.03) and positively associated with systolic and diastolic blood pressure (r = 0.77, p = 0.04, r = 0.79, p = 0.03, respectively) in the sub-group of PCOS women with abnormal glucose tolerance (AGT).

CONCLUSIONS

Asian PCOS women had significantly higher serum visfatin levels than age-matched healthy controls. Their levels were significantly correlated with 2hPG and blood pressure in PCOS women, and with FI and blood pressure in PCOS women with AGT.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Ratchatawee, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19533482

Citation

Jongwutiwes, Theerayut, et al. "Serum Visfatin in Asian Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 25, no. 8, 2009, pp. 536-42.
Jongwutiwes T, Lertvikool S, Leelaphiwat S, et al. Serum visfatin in Asian women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25(8):536-42.
Jongwutiwes, T., Lertvikool, S., Leelaphiwat, S., Rattanasiri, S., Jultanmas, R., & Weerakiet, S. (2009). Serum visfatin in Asian women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 25(8), pp. 536-42. doi:10.1080/09513590903015478.
Jongwutiwes T, et al. Serum Visfatin in Asian Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2009;25(8):536-42. PubMed PMID: 19533482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum visfatin in Asian women with polycystic ovary syndrome. AU - Jongwutiwes,Theerayut, AU - Lertvikool,Srithean, AU - Leelaphiwat,Supatra, AU - Rattanasiri,Sasivimol, AU - Jultanmas,Rattiya, AU - Weerakiet,Sawaek, PY - 2009/6/18/entrez PY - 2009/6/18/pubmed PY - 2010/1/28/medline SP - 536 EP - 42 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 25 IS - 8 N2 - OBJECTIVE: To determine serum visfatin levels in Asian polycystic ovary syndrome (PCOS) women and its correlations with various parameters. STUDY DESIGN: Case-control study. SETTING: University hospital. SUBJECTS: Eighty women were enrolled in this study. Of these, 40 women were PCOS and 40 age-matched subjects with regular menstrual cycles were controls. INTERVENTION: Seventy-five gram oral glucose tolerance tests were performed in all women. Fasting venous blood samples for serum visfatin, insulin and androgen levels were obtained both from the PCOS and the control women. MAIN OUTCOME MEASURES: Serum concentrations of visfatin, fasting insulin (FI), fasting glucose, 2-h post-load glucose (2hPG), homeostasis model assessment insulin resistance, homeostasis model assessment beta cell function, total testosterone, free testosterone, androstenedione and dehydroepiandrosterone sulfate were measured in both groups. RESULTS: Women with PCOS had significantly higher serum visfatin levels than the healthy controls [100.39 +/- 41.90 vs. 45.09 +/- 28.24 mg/ml, p < 0.01]. PCOS women also had significantly higher concentrations of all androgens (p < 0.01). Insulin resistance seemed to be greater in the PCOS than the control groups, but did not reach a statistically significant level. In the PCOS group, serum visfatin levels were positively correlated with 2hPG, and systolic blood pressure and diastolic blood pressure. Serum visfatin levels were negatively associated with FI (r = -0.80, p = 0.03) and positively associated with systolic and diastolic blood pressure (r = 0.77, p = 0.04, r = 0.79, p = 0.03, respectively) in the sub-group of PCOS women with abnormal glucose tolerance (AGT). CONCLUSIONS: Asian PCOS women had significantly higher serum visfatin levels than age-matched healthy controls. Their levels were significantly correlated with 2hPG and blood pressure in PCOS women, and with FI and blood pressure in PCOS women with AGT. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/19533482/Serum_visfatin_in_Asian_women_with_polycystic_ovary_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590903015478 DB - PRIME DP - Unbound Medicine ER -