Tags

Type your tag names separated by a space and hit enter

Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain.
J Rehabil Res Dev 2009; 46(1):135-43JR

Abstract

A significant complaint associated with spinal cord injury (SCI) is chronic pain, which includes symptoms such as cutaneous hypersensitivity and spontaneous unevoked pain and is difficult to treat with currently available drugs. One complication with current analgesics is tolerance, a decrease in efficacy with repeated treatment over time. One promising class of pharmacological treatment is cannabinoid (CB) receptor agonists. The current study assessed the efficacy of the CB receptor agonist WIN 55,212-2 (WIN) in a rat model of neuropathic SCI pain. Brief spinal compression leads to significant hindpaw hypersensitivity to tactile stimulation. WIN dose-dependently increased withdrawal thresholds and continued to demonstrate efficacy over a twice-daily 7-day treatment regimen. By contrast, the efficacy of morphine in SCI rats decreased over the same treatment period. Similarly, the antinociceptive efficacy of WIN to acute noxious heat in uninjured rats diminished over time. These data suggest that the sustained efficacy of a CB receptor agonist for pain could depend on the pain state. Such agonists may hold promise for long-term use in alleviating chronic SCI pain.

Authors+Show Affiliations

The Miami Project to Cure Paralysis, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA. ahama@med.miami.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19533526

Citation

Hama, Aldric, and Jacqueline Sagen. "Sustained Antinociceptive Effect of Cannabinoid Receptor Agonist WIN 55,212-2 Over Time in Rat Model of Neuropathic Spinal Cord Injury Pain." Journal of Rehabilitation Research and Development, vol. 46, no. 1, 2009, pp. 135-43.
Hama A, Sagen J. Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain. J Rehabil Res Dev. 2009;46(1):135-43.
Hama, A., & Sagen, J. (2009). Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain. Journal of Rehabilitation Research and Development, 46(1), pp. 135-43.
Hama A, Sagen J. Sustained Antinociceptive Effect of Cannabinoid Receptor Agonist WIN 55,212-2 Over Time in Rat Model of Neuropathic Spinal Cord Injury Pain. J Rehabil Res Dev. 2009;46(1):135-43. PubMed PMID: 19533526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain. AU - Hama,Aldric, AU - Sagen,Jacqueline, PY - 2009/6/18/entrez PY - 2009/6/18/pubmed PY - 2009/9/3/medline SP - 135 EP - 43 JF - Journal of rehabilitation research and development JO - J Rehabil Res Dev VL - 46 IS - 1 N2 - A significant complaint associated with spinal cord injury (SCI) is chronic pain, which includes symptoms such as cutaneous hypersensitivity and spontaneous unevoked pain and is difficult to treat with currently available drugs. One complication with current analgesics is tolerance, a decrease in efficacy with repeated treatment over time. One promising class of pharmacological treatment is cannabinoid (CB) receptor agonists. The current study assessed the efficacy of the CB receptor agonist WIN 55,212-2 (WIN) in a rat model of neuropathic SCI pain. Brief spinal compression leads to significant hindpaw hypersensitivity to tactile stimulation. WIN dose-dependently increased withdrawal thresholds and continued to demonstrate efficacy over a twice-daily 7-day treatment regimen. By contrast, the efficacy of morphine in SCI rats decreased over the same treatment period. Similarly, the antinociceptive efficacy of WIN to acute noxious heat in uninjured rats diminished over time. These data suggest that the sustained efficacy of a CB receptor agonist for pain could depend on the pain state. Such agonists may hold promise for long-term use in alleviating chronic SCI pain. SN - 1938-1352 UR - https://www.unboundmedicine.com/medline/citation/19533526/Sustained_antinociceptive_effect_of_cannabinoid_receptor_agonist_WIN_55212_2_over_time_in_rat_model_of_neuropathic_spinal_cord_injury_pain_ L2 - https://www.rehab.research.va.gov/jour/09/46/1/pdf/Hama.pdf DB - PRIME DP - Unbound Medicine ER -