Tags

Type your tag names separated by a space and hit enter

The polarised life of the endocannabinoid system in CNS development.
Chembiochem 2009; 10(10):1591-8C

Abstract

The spatiotemporal expression of cannabinoid receptors and endocannabinoid-metabolising enzymes during brain development guides major developmental processes including neurogenesis, cell differentiation, cell migration, neuronal specification and synaptogenesis.Endocannabinoids (eCBs) play an important role in fine-tuning neurotransmission and have recently been shown to play an important role in brain development. The spatiotemporal expression of cannabinoid receptors and endocannabinoid-metabolising enzymes during development guides major developmental processes including neurogenesis, cell differentiation, cell migration, neuronal specification and synaptogenesis. Furthermore, pharmacological experiments and transgenic animal models have shown the impact of disrupted eCB signalling on normal brain development and revealed the danger of both cannabis abuse and exposure to cannabinoid drugs during embryonic development, childhood and adolescence. In this review, we focus on the dynamic expression of eCB components and the physiological role eCBs play during brain development.

Authors+Show Affiliations

Institute of Medical Sciences, School of Medical Sciences, University of Aberdeen, Aberdeen, UK.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19533710

Citation

Anavi-Goffer, Sharon, and Jan Mulder. "The Polarised Life of the Endocannabinoid System in CNS Development." Chembiochem : a European Journal of Chemical Biology, vol. 10, no. 10, 2009, pp. 1591-8.
Anavi-Goffer S, Mulder J. The polarised life of the endocannabinoid system in CNS development. Chembiochem. 2009;10(10):1591-8.
Anavi-Goffer, S., & Mulder, J. (2009). The polarised life of the endocannabinoid system in CNS development. Chembiochem : a European Journal of Chemical Biology, 10(10), pp. 1591-8. doi:10.1002/cbic.200800827.
Anavi-Goffer S, Mulder J. The Polarised Life of the Endocannabinoid System in CNS Development. Chembiochem. 2009 Jul 6;10(10):1591-8. PubMed PMID: 19533710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The polarised life of the endocannabinoid system in CNS development. AU - Anavi-Goffer,Sharon, AU - Mulder,Jan, PY - 2009/6/18/entrez PY - 2009/6/18/pubmed PY - 2009/10/9/medline SP - 1591 EP - 8 JF - Chembiochem : a European journal of chemical biology JO - Chembiochem VL - 10 IS - 10 N2 - The spatiotemporal expression of cannabinoid receptors and endocannabinoid-metabolising enzymes during brain development guides major developmental processes including neurogenesis, cell differentiation, cell migration, neuronal specification and synaptogenesis.Endocannabinoids (eCBs) play an important role in fine-tuning neurotransmission and have recently been shown to play an important role in brain development. The spatiotemporal expression of cannabinoid receptors and endocannabinoid-metabolising enzymes during development guides major developmental processes including neurogenesis, cell differentiation, cell migration, neuronal specification and synaptogenesis. Furthermore, pharmacological experiments and transgenic animal models have shown the impact of disrupted eCB signalling on normal brain development and revealed the danger of both cannabis abuse and exposure to cannabinoid drugs during embryonic development, childhood and adolescence. In this review, we focus on the dynamic expression of eCB components and the physiological role eCBs play during brain development. SN - 1439-7633 UR - https://www.unboundmedicine.com/medline/citation/19533710/The_polarised_life_of_the_endocannabinoid_system_in_CNS_development_ L2 - https://doi.org/10.1002/cbic.200800827 DB - PRIME DP - Unbound Medicine ER -