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Parsing brain activity associated with acupuncture treatment in Parkinson's diseases.

Abstract

Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood-oxygen-level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia-thalamocortical circuit.

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  • Authors+Show Affiliations

    ,

    Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.

    , , , , ,

    Source

    MeSH

    Acupuncture Therapy
    Adult
    Aged
    Brain
    Brain Mapping
    Double-Blind Method
    Female
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Oxygen
    Parkinson Disease
    Psychomotor Performance
    Severity of Illness Index

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19533753

    Citation

    Chae, Younbyoung, et al. "Parsing Brain Activity Associated With Acupuncture Treatment in Parkinson's Diseases." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 24, no. 12, 2009, pp. 1794-802.
    Chae Y, Lee H, Kim H, et al. Parsing brain activity associated with acupuncture treatment in Parkinson's diseases. Mov Disord. 2009;24(12):1794-802.
    Chae, Y., Lee, H., Kim, H., Kim, C. H., Chang, D. I., Kim, K. M., & Park, H. J. (2009). Parsing brain activity associated with acupuncture treatment in Parkinson's diseases. Movement Disorders : Official Journal of the Movement Disorder Society, 24(12), pp. 1794-802. doi:10.1002/mds.22673.
    Chae Y, et al. Parsing Brain Activity Associated With Acupuncture Treatment in Parkinson's Diseases. Mov Disord. 2009 Sep 15;24(12):1794-802. PubMed PMID: 19533753.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Parsing brain activity associated with acupuncture treatment in Parkinson's diseases. AU - Chae,Younbyoung, AU - Lee,Hyejung, AU - Kim,Hackjin, AU - Kim,Chang-Hwan, AU - Chang,Dae-Il, AU - Kim,Kyung-Mi, AU - Park,Hi-Joon, PY - 2009/6/18/entrez PY - 2009/6/18/pubmed PY - 2009/12/16/medline SP - 1794 EP - 802 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 24 IS - 12 N2 - Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood-oxygen-level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia-thalamocortical circuit. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/19533753/ L2 - https://doi.org/10.1002/mds.22673 DB - PRIME DP - Unbound Medicine ER -