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Prevalence of small intestinal bacterial overgrowth in children with irritable bowel syndrome: a case-control study.
J Pediatr 2009; 155(3):416-20JPed

Abstract

OBJECTIVE

To assess the prevalence of small intestinal bacterial overgrowth (SIBO) in children affected by irritable bowel syndrome (IBS).

STUDY DESIGN

Consecutive children affected by IBS according to Rome II criteria (n = 43) were enrolled at the Gemelli Hospital, Catholic University of Rome. The control population (n = 56) consisted of healthy subjects without IBS symptoms, similar to patients for age, sex, and social background. All subjects underwent lactulose/methane breath test (LBT) to assess small intestinal bacterial overgrowth.

RESULTS

The prevalence of abnormal LBT result was significantly higher in patients with IBS (65%, 28/43) with respect to control subjects (7%, 4/56; OR 3.9, 95% CI 7.3-80.1, P < .00001). Patients with abnormal LBT showed a trend toward a worse visual analog scale score with respect to children with IBS without SIBO, but a significant statistical difference was observed only for bloating.

CONCLUSIONS

Results from this study suggest a significant epidemiologic association between SIBO and IBS in childhood. Placebo-controlled interventional studies with antibiotics used to treat bacterial overgrowth are warranted to clarify the real impact of the disease on IBS symptoms.

Authors+Show Affiliations

Internal Medicine Department, Catholic University of Sacred Heart, Gemelli Hospital, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19535093

Citation

Scarpellini, E, et al. "Prevalence of Small Intestinal Bacterial Overgrowth in Children With Irritable Bowel Syndrome: a Case-control Study." The Journal of Pediatrics, vol. 155, no. 3, 2009, pp. 416-20.
Scarpellini E, Giorgio V, Gabrielli M, et al. Prevalence of small intestinal bacterial overgrowth in children with irritable bowel syndrome: a case-control study. J Pediatr. 2009;155(3):416-20.
Scarpellini, E., Giorgio, V., Gabrielli, M., Lauritano, E. C., Pantanella, A., Fundarò, C., & Gasbarrini, A. (2009). Prevalence of small intestinal bacterial overgrowth in children with irritable bowel syndrome: a case-control study. The Journal of Pediatrics, 155(3), pp. 416-20. doi:10.1016/j.jpeds.2009.03.033.
Scarpellini E, et al. Prevalence of Small Intestinal Bacterial Overgrowth in Children With Irritable Bowel Syndrome: a Case-control Study. J Pediatr. 2009;155(3):416-20. PubMed PMID: 19535093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of small intestinal bacterial overgrowth in children with irritable bowel syndrome: a case-control study. AU - Scarpellini,E, AU - Giorgio,V, AU - Gabrielli,M, AU - Lauritano,E C, AU - Pantanella,A, AU - Fundarò,C, AU - Gasbarrini,A, Y1 - 2009/06/16/ PY - 2008/08/18/received PY - 2009/01/07/revised PY - 2009/03/16/accepted PY - 2009/6/19/entrez PY - 2009/6/19/pubmed PY - 2009/10/1/medline SP - 416 EP - 20 JF - The Journal of pediatrics JO - J. Pediatr. VL - 155 IS - 3 N2 - OBJECTIVE: To assess the prevalence of small intestinal bacterial overgrowth (SIBO) in children affected by irritable bowel syndrome (IBS). STUDY DESIGN: Consecutive children affected by IBS according to Rome II criteria (n = 43) were enrolled at the Gemelli Hospital, Catholic University of Rome. The control population (n = 56) consisted of healthy subjects without IBS symptoms, similar to patients for age, sex, and social background. All subjects underwent lactulose/methane breath test (LBT) to assess small intestinal bacterial overgrowth. RESULTS: The prevalence of abnormal LBT result was significantly higher in patients with IBS (65%, 28/43) with respect to control subjects (7%, 4/56; OR 3.9, 95% CI 7.3-80.1, P < .00001). Patients with abnormal LBT showed a trend toward a worse visual analog scale score with respect to children with IBS without SIBO, but a significant statistical difference was observed only for bloating. CONCLUSIONS: Results from this study suggest a significant epidemiologic association between SIBO and IBS in childhood. Placebo-controlled interventional studies with antibiotics used to treat bacterial overgrowth are warranted to clarify the real impact of the disease on IBS symptoms. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/19535093/Prevalence_of_small_intestinal_bacterial_overgrowth_in_children_with_irritable_bowel_syndrome:_a_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(09)00247-9 DB - PRIME DP - Unbound Medicine ER -