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Angiostatic versus angiogenic chemokines in IPF and EAA.
Respir Med. 2009 Nov; 103(11):1651-6.RM

Abstract

BACKGROUND

Extrinsic allergic alveolitis (EAA) and idiopathic pulmonary fibrosis (IPF) share the presence of varying degree interstitial involvement and fibrosis. Vascular changes were often reported to accompany the development of fibrosis.

OBJECTIVES

The aim of our study was to examine the differences in angiostatic and angiogenic chemokine milieu in both diseases. Correlations between chemokine levels in bronchoalveolar lavage fluid (BALF), expression of chemokine receptors on CD4+ T cells (CXCR2, CXCR3) in BALF and HRCT pattern of the diseases were investigated.

METHODS

Sixteen patients with chronic EAA and 8 with IPF were enrolled to the study. Concentrations of interleukin (IL)-8, epithelial neutrophil activating protein (ENA)-78, interferon-gamma-inducible protein (IP)-10 and interferon-inducible T cell alpha chemoattractant (I-TAC) in BALF supernatants were quantified using Fluorokine MultiAnalyte profiling.

RESULTS

There was no significant difference in the BALF chemokine levels between the EAA and IPF group. IL-8 BALF concentrations correlate with the extent of fibrosis in both EAA and IPF (p<0.01). The IP-10 BALF concentrations do not correlate either with the HRCT alveolar or interstitial score and should be evaluated in the relationship with the disease course.

CONCLUSIONS

Both IL-8 and ENA-78 probably play a different role in IPF and chronic EAA pathogenesis. While we suggest ENA-78 as the marker of at least partial reversibility of the lung impairment in the EAA patients, IL-8 could be rather an indicator of continuous exposition to provoking agent in EAA patients. IL-8 might serve as a potential marker of early phase of IPF.

Authors+Show Affiliations

Department of Respiratory Medicine, Thomayer's University Hospital, Prague, Czech Republic. martinasafrankova@seznam.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19535235

Citation

Martina, Sterclova, et al. "Angiostatic Versus Angiogenic Chemokines in IPF and EAA." Respiratory Medicine, vol. 103, no. 11, 2009, pp. 1651-6.
Martina S, Martina V, Monika M, et al. Angiostatic versus angiogenic chemokines in IPF and EAA. Respir Med. 2009;103(11):1651-6.
Martina, S., Martina, V., Monika, M., Jan, P., Libor, K., & Ilja, S. (2009). Angiostatic versus angiogenic chemokines in IPF and EAA. Respiratory Medicine, 103(11), 1651-6. https://doi.org/10.1016/j.rmed.2009.05.012
Martina S, et al. Angiostatic Versus Angiogenic Chemokines in IPF and EAA. Respir Med. 2009;103(11):1651-6. PubMed PMID: 19535235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiostatic versus angiogenic chemokines in IPF and EAA. AU - Martina,Sterclova, AU - Martina,Vasakova, AU - Monika,Metlicka, AU - Jan,Pavlicek, AU - Libor,Kolesar, AU - Ilja,Striz, Y1 - 2009/06/16/ PY - 2009/02/21/received PY - 2009/04/20/revised PY - 2009/05/11/accepted PY - 2009/6/19/entrez PY - 2009/6/19/pubmed PY - 2010/8/31/medline SP - 1651 EP - 6 JF - Respiratory medicine JO - Respir Med VL - 103 IS - 11 N2 - BACKGROUND: Extrinsic allergic alveolitis (EAA) and idiopathic pulmonary fibrosis (IPF) share the presence of varying degree interstitial involvement and fibrosis. Vascular changes were often reported to accompany the development of fibrosis. OBJECTIVES: The aim of our study was to examine the differences in angiostatic and angiogenic chemokine milieu in both diseases. Correlations between chemokine levels in bronchoalveolar lavage fluid (BALF), expression of chemokine receptors on CD4+ T cells (CXCR2, CXCR3) in BALF and HRCT pattern of the diseases were investigated. METHODS: Sixteen patients with chronic EAA and 8 with IPF were enrolled to the study. Concentrations of interleukin (IL)-8, epithelial neutrophil activating protein (ENA)-78, interferon-gamma-inducible protein (IP)-10 and interferon-inducible T cell alpha chemoattractant (I-TAC) in BALF supernatants were quantified using Fluorokine MultiAnalyte profiling. RESULTS: There was no significant difference in the BALF chemokine levels between the EAA and IPF group. IL-8 BALF concentrations correlate with the extent of fibrosis in both EAA and IPF (p<0.01). The IP-10 BALF concentrations do not correlate either with the HRCT alveolar or interstitial score and should be evaluated in the relationship with the disease course. CONCLUSIONS: Both IL-8 and ENA-78 probably play a different role in IPF and chronic EAA pathogenesis. While we suggest ENA-78 as the marker of at least partial reversibility of the lung impairment in the EAA patients, IL-8 could be rather an indicator of continuous exposition to provoking agent in EAA patients. IL-8 might serve as a potential marker of early phase of IPF. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/19535235/Angiostatic_versus_angiogenic_chemokines_in_IPF_and_EAA_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(09)00165-6 DB - PRIME DP - Unbound Medicine ER -