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Stearate-enriched plant sterol esters lower serum LDL cholesterol concentration in normo- and hypercholesterolemic adults.
J Nutr. 2009 Aug; 139(8):1445-50.JN

Abstract

Studies in our laboratory have previously demonstrated in hamsters a superior cholesterol-lowering ability of plant sterol (PS) esters enriched in stearate compared with linoleate. We therefore conducted a randomized, double-blind, 2-group parallel, placebo-controlled study to test the cholesterol-lowering properties of stearate-enriched PS esters in normo- and hypercholesterolemic adults. Thirty-two adults, 16 per group with equal number of males and females in each group, participated in the 4-wk study. Participants consumed 3 g/d (1 g three times per day with meals) of either PS esters or placebo delivered in capsules. Serum LDL cholesterol concentration significantly decreased 0.42 mmol/L (11%) and the LDL:HDL cholesterol ratio decreased 10% with PS ester supplementation, whereas LDL particle size and lipoprotein subclass particle concentrations (as measured by NMR) were not affected. The percent change in LDL cholesterol was positively correlated with baseline lathosterol concentration (r = 0.729; P = 0.0014), indicating an association between the magnitude of LDL change and the rate of whole-body cholesterol synthesis. Serum campesterol (but not sitosterol) concentration significantly increased in the PS ester group. Serum tocopherol, retinol, and beta-carotene concentrations were not affected by PS ester supplementation. Thus, our findings demonstrate the usefulness of a novel stearate-enriched PS ester compound in decreasing LDL cholesterol in both normo- and hypercholesterolemic adults. The extent to which PS ester fatty acid composition affects intestinal micelle formation and cholesterol absorption in humans requires further study.

Authors+Show Affiliations

Departments of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583, USA. tcarr2@unl.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19535421

Citation

Carr, Timothy P., et al. "Stearate-enriched Plant Sterol Esters Lower Serum LDL Cholesterol Concentration in Normo- and Hypercholesterolemic Adults." The Journal of Nutrition, vol. 139, no. 8, 2009, pp. 1445-50.
Carr TP, Krogstrand KL, Schlegel VL, et al. Stearate-enriched plant sterol esters lower serum LDL cholesterol concentration in normo- and hypercholesterolemic adults. J Nutr. 2009;139(8):1445-50.
Carr, T. P., Krogstrand, K. L., Schlegel, V. L., & Fernandez, M. L. (2009). Stearate-enriched plant sterol esters lower serum LDL cholesterol concentration in normo- and hypercholesterolemic adults. The Journal of Nutrition, 139(8), 1445-50. https://doi.org/10.3945/jn.109.106328
Carr TP, et al. Stearate-enriched Plant Sterol Esters Lower Serum LDL Cholesterol Concentration in Normo- and Hypercholesterolemic Adults. J Nutr. 2009;139(8):1445-50. PubMed PMID: 19535421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stearate-enriched plant sterol esters lower serum LDL cholesterol concentration in normo- and hypercholesterolemic adults. AU - Carr,Timothy P, AU - Krogstrand,Kaye L Stanek, AU - Schlegel,Vicki L, AU - Fernandez,Maria Luz, Y1 - 2009/06/17/ PY - 2009/6/19/entrez PY - 2009/6/19/pubmed PY - 2009/8/14/medline SP - 1445 EP - 50 JF - The Journal of nutrition JO - J. Nutr. VL - 139 IS - 8 N2 - Studies in our laboratory have previously demonstrated in hamsters a superior cholesterol-lowering ability of plant sterol (PS) esters enriched in stearate compared with linoleate. We therefore conducted a randomized, double-blind, 2-group parallel, placebo-controlled study to test the cholesterol-lowering properties of stearate-enriched PS esters in normo- and hypercholesterolemic adults. Thirty-two adults, 16 per group with equal number of males and females in each group, participated in the 4-wk study. Participants consumed 3 g/d (1 g three times per day with meals) of either PS esters or placebo delivered in capsules. Serum LDL cholesterol concentration significantly decreased 0.42 mmol/L (11%) and the LDL:HDL cholesterol ratio decreased 10% with PS ester supplementation, whereas LDL particle size and lipoprotein subclass particle concentrations (as measured by NMR) were not affected. The percent change in LDL cholesterol was positively correlated with baseline lathosterol concentration (r = 0.729; P = 0.0014), indicating an association between the magnitude of LDL change and the rate of whole-body cholesterol synthesis. Serum campesterol (but not sitosterol) concentration significantly increased in the PS ester group. Serum tocopherol, retinol, and beta-carotene concentrations were not affected by PS ester supplementation. Thus, our findings demonstrate the usefulness of a novel stearate-enriched PS ester compound in decreasing LDL cholesterol in both normo- and hypercholesterolemic adults. The extent to which PS ester fatty acid composition affects intestinal micelle formation and cholesterol absorption in humans requires further study. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/19535421/Stearate_enriched_plant_sterol_esters_lower_serum_LDL_cholesterol_concentration_in_normo__and_hypercholesterolemic_adults_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.109.106328 DB - PRIME DP - Unbound Medicine ER -