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Intervention study with a high or low antioxidant capacity diet: effects on circulating beta-carotene.
Eur J Clin Nutr. 2009 Oct; 63(10):1220-5.EJ

Abstract

BACKGROUND AND OBJECTIVES

A cross-sectional observation suggests that total antioxidant capacity (TAC) of the diet positively affects plasma concentrations of beta-carotene independent of beta-carotene intake. This study was carried out to investigate the effect of two dietary strategies, designed to be comparable in fruits, vegetables, fibre, alcohol and beta-carotene intake but substantially different in their TAC, on changes in antioxidant intake and antioxidant status, and in particular in circulating beta-carotene concentrations.

SUBJECTS

A randomized cross-over intervention trial involving 33 healthy participants and consisting of two 14-day dietary periods (high TAC diet, HT; low TAC diet, LT) with a 14-day washout in between was conducted.

RESULTS

Energy, macronutrient, dietary fibre, alcohol and beta-carotene intake was not significantly different between LT and HT, whereas intake of other carotenoids and dietary TAC was significantly higher in the HT than in the LT (P<0.001). Circulating carotenoids (with the exception of alpha-carotene, which followed an inverse trend) and alpha-tocopherol decreased significantly during the LT and increased during the HT period. Among these, beta-carotene almost doubled its concentration in plasma after the HT diet.

CONCLUSIONS

The increase in circulating beta-carotene along with the increase in dietary TAC suggests that plasma beta-carotene could be a marker of TAC intake rather than of beta-carotene intake itself. This may explain, in part, why beta-carotene supplementation alone has shown no benefit in chronic disease prevention and adds to a putative beneficial role of high dietary TAC diets, which merits further investigation.

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Authors+Show Affiliations

Del Rio D
Human Nutrition Unit, Department of Public Health, University of Parma, Parma, Italy.
Valtueña S
No affiliation info available
Pellegrini N
No affiliation info available
Bianchi MA
No affiliation info available
Ardigò D
No affiliation info available
Franzini L
No affiliation info available
Scazzina F
No affiliation info available
Monti L
No affiliation info available
Zavaroni I
No affiliation info available
Brighenti F
No affiliation info available

MeSH

Alcohol DrinkingAntioxidantsBiomarkersCross-Over StudiesDietary FiberFemaleFree Radical ScavengersFruitHumansInflammationLiver DiseasesMaleMiddle AgedOxidation-ReductionOxidative StressVegetablesVitaminsbeta Carotene

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19536163

Citation

Del Rio, D, et al. "Intervention Study With a High or Low Antioxidant Capacity Diet: Effects On Circulating Beta-carotene." European Journal of Clinical Nutrition, vol. 63, no. 10, 2009, pp. 1220-5.
Del Rio D, Valtueña S, Pellegrini N, et al. Intervention study with a high or low antioxidant capacity diet: effects on circulating beta-carotene. Eur J Clin Nutr. 2009;63(10):1220-5.
Del Rio, D., Valtueña, S., Pellegrini, N., Bianchi, M. A., Ardigò, D., Franzini, L., Scazzina, F., Monti, L., Zavaroni, I., & Brighenti, F. (2009). Intervention study with a high or low antioxidant capacity diet: effects on circulating beta-carotene. European Journal of Clinical Nutrition, 63(10), 1220-5. https://doi.org/10.1038/ejcn.2009.46
Del Rio D, et al. Intervention Study With a High or Low Antioxidant Capacity Diet: Effects On Circulating Beta-carotene. Eur J Clin Nutr. 2009;63(10):1220-5. PubMed PMID: 19536163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intervention study with a high or low antioxidant capacity diet: effects on circulating beta-carotene. AU - Del Rio,D, AU - Valtueña,S, AU - Pellegrini,N, AU - Bianchi,M A, AU - Ardigò,D, AU - Franzini,L, AU - Scazzina,F, AU - Monti,L, AU - Zavaroni,I, AU - Brighenti,F, Y1 - 2009/06/17/ PY - 2009/6/19/entrez PY - 2009/6/19/pubmed PY - 2010/1/5/medline SP - 1220 EP - 5 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 63 IS - 10 N2 - BACKGROUND AND OBJECTIVES: A cross-sectional observation suggests that total antioxidant capacity (TAC) of the diet positively affects plasma concentrations of beta-carotene independent of beta-carotene intake. This study was carried out to investigate the effect of two dietary strategies, designed to be comparable in fruits, vegetables, fibre, alcohol and beta-carotene intake but substantially different in their TAC, on changes in antioxidant intake and antioxidant status, and in particular in circulating beta-carotene concentrations. SUBJECTS: A randomized cross-over intervention trial involving 33 healthy participants and consisting of two 14-day dietary periods (high TAC diet, HT; low TAC diet, LT) with a 14-day washout in between was conducted. RESULTS: Energy, macronutrient, dietary fibre, alcohol and beta-carotene intake was not significantly different between LT and HT, whereas intake of other carotenoids and dietary TAC was significantly higher in the HT than in the LT (P<0.001). Circulating carotenoids (with the exception of alpha-carotene, which followed an inverse trend) and alpha-tocopherol decreased significantly during the LT and increased during the HT period. Among these, beta-carotene almost doubled its concentration in plasma after the HT diet. CONCLUSIONS: The increase in circulating beta-carotene along with the increase in dietary TAC suggests that plasma beta-carotene could be a marker of TAC intake rather than of beta-carotene intake itself. This may explain, in part, why beta-carotene supplementation alone has shown no benefit in chronic disease prevention and adds to a putative beneficial role of high dietary TAC diets, which merits further investigation. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/19536163/Intervention_study_with_a_high_or_low_antioxidant_capacity_diet:_effects_on_circulating_beta_carotene_ L2 - https://doi.org/10.1038/ejcn.2009.46 DB - PRIME DP - Unbound Medicine ER -