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The association of HLA-B*27 subtypes with ankylosing spondylitis in Wuhan population of China.
Rheumatol Int. 2010 Mar; 30(5):587-90.RI

Abstract

The aim of this study was to investigate the association of the B27 subtypes with ankylosing spondylitis (AS) in the Wuhan population of China. We selected 317 HLA-B27-positive individuals (145 controls and 172 patients with ankylosing spondylitis). The B27 subtypes were characterized using a PCR-SSP method. Six B27 subtypes were determined: B*2702, 03, 04, 05, 06 and B*13. HLA-B*2704 and HLA-B*2705 were the two high frequency genotypes in controls and patients. Compared with the controls, the AS patients had high frequency of B*2704 (patients 69.2% vs. controls 53.8%) and low frequency of B*2705 (patients 23.8% vs. controls 33.1%). B*2703 was detected in 10 (5.8%) patients and in 13 (8.9%) controls. B*2702, 06 and B*2713 were relatively rare. Our results show that the allele conferring risk to AS in the Wuhan population of China was B*2704 and B*2705. B*2704 is strongly associated with AS.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Liu X
Clinical Laboratory Medicine Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hu LH
No affiliation info available
Li YR
No affiliation info available
Chen FH
No affiliation info available
Ning Y
No affiliation info available
Yao QF
No affiliation info available

MeSH

AdolescentAdultAsian Continental Ancestry GroupCase-Control StudiesChi-Square DistributionChinaDNA PrimersFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHLA-B AntigensHLA-B27 AntigenHumansMaleMiddle AgedPhenotypePolymerase Chain ReactionPolymorphism, GeneticRisk AssessmentRisk FactorsSpondylitis, AnkylosingYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19536542

Citation

Liu, Xiang, et al. "The Association of HLA-B*27 Subtypes With Ankylosing Spondylitis in Wuhan Population of China." Rheumatology International, vol. 30, no. 5, 2010, pp. 587-90.
Liu X, Hu LH, Li YR, et al. The association of HLA-B*27 subtypes with ankylosing spondylitis in Wuhan population of China. Rheumatol Int. 2010;30(5):587-90.
Liu, X., Hu, L. H., Li, Y. R., Chen, F. H., Ning, Y., & Yao, Q. F. (2010). The association of HLA-B*27 subtypes with ankylosing spondylitis in Wuhan population of China. Rheumatology International, 30(5), 587-90. https://doi.org/10.1007/s00296-009-1018-0
Liu X, et al. The Association of HLA-B*27 Subtypes With Ankylosing Spondylitis in Wuhan Population of China. Rheumatol Int. 2010;30(5):587-90. PubMed PMID: 19536542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of HLA-B*27 subtypes with ankylosing spondylitis in Wuhan population of China. AU - Liu,Xiang, AU - Hu,Li-Hua, AU - Li,Yi-Rong, AU - Chen,Feng-Hua, AU - Ning,Yong, AU - Yao,Qun-Feng, Y1 - 2009/06/18/ PY - 2009/03/14/received PY - 2009/06/02/accepted PY - 2009/6/19/entrez PY - 2009/6/19/pubmed PY - 2010/4/30/medline SP - 587 EP - 90 JF - Rheumatology international JO - Rheumatol Int VL - 30 IS - 5 N2 - The aim of this study was to investigate the association of the B27 subtypes with ankylosing spondylitis (AS) in the Wuhan population of China. We selected 317 HLA-B27-positive individuals (145 controls and 172 patients with ankylosing spondylitis). The B27 subtypes were characterized using a PCR-SSP method. Six B27 subtypes were determined: B*2702, 03, 04, 05, 06 and B*13. HLA-B*2704 and HLA-B*2705 were the two high frequency genotypes in controls and patients. Compared with the controls, the AS patients had high frequency of B*2704 (patients 69.2% vs. controls 53.8%) and low frequency of B*2705 (patients 23.8% vs. controls 33.1%). B*2703 was detected in 10 (5.8%) patients and in 13 (8.9%) controls. B*2702, 06 and B*2713 were relatively rare. Our results show that the allele conferring risk to AS in the Wuhan population of China was B*2704 and B*2705. B*2704 is strongly associated with AS. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/19536542/The_association_of_HLA_B_27_subtypes_with_ankylosing_spondylitis_in_Wuhan_population_of_China_ L2 - https://dx.doi.org/10.1007/s00296-009-1018-0 DB - PRIME DP - Unbound Medicine ER -