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Medication adherence in HIV-infected smokers: the mediating role of depressive symptoms.
AIDS Educ Prev. 2009 Jun; 21(3 Suppl):94-105.AE

Abstract

Strict medication adherence is integral to the success of highly active antiretroviral therapies (HAART) in patients with HIV. Research has examined several predictors of adherence, but few studies have examined the association between current smoking, which is highly prevalent among people living with HIV, and medication adherence; moreover, no study has examined the mediating role of depressive symptoms, which may influence both smoking and adherence. Therefore, we recruited 168 patients who were prescribed HAART and assessed viral load, CD4+ count, cigarette smoking, past week and 3-month medication adherence, and depressive symptoms. Results showed that 70% smoked at least one cigarette per day. As predicted, smoking was associated with poorer past week and 3-month adherence, and more depressive symptoms. Regression analyses provided partial support for the hypothesis that depressive symptoms mediated nonadherence among smokers. We conclude that future smoking cessation interventions with this population should target medical adherence and depression as intervention components.

Authors+Show Affiliations

Department of Psychology, University of Miami, PO Box 248185, Coral Gables, FL 33124-0751, USA. mwebb@miami.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19537957

Citation

Webb, Monica S., et al. "Medication Adherence in HIV-infected Smokers: the Mediating Role of Depressive Symptoms." AIDS Education and Prevention : Official Publication of the International Society for AIDS Education, vol. 21, no. 3 Suppl, 2009, pp. 94-105.
Webb MS, Vanable PA, Carey MP, et al. Medication adherence in HIV-infected smokers: the mediating role of depressive symptoms. AIDS Educ Prev. 2009;21(3 Suppl):94-105.
Webb, M. S., Vanable, P. A., Carey, M. P., & Blair, D. C. (2009). Medication adherence in HIV-infected smokers: the mediating role of depressive symptoms. AIDS Education and Prevention : Official Publication of the International Society for AIDS Education, 21(3 Suppl), 94-105. https://doi.org/10.1521/aeap.2009.21.3_supp.94
Webb MS, et al. Medication Adherence in HIV-infected Smokers: the Mediating Role of Depressive Symptoms. AIDS Educ Prev. 2009;21(3 Suppl):94-105. PubMed PMID: 19537957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medication adherence in HIV-infected smokers: the mediating role of depressive symptoms. AU - Webb,Monica S, AU - Vanable,Peter A, AU - Carey,Michael P, AU - Blair,Donald C, PY - 2009/6/23/entrez PY - 2009/6/27/pubmed PY - 2009/7/14/medline SP - 94 EP - 105 JF - AIDS education and prevention : official publication of the International Society for AIDS Education JO - AIDS Educ Prev VL - 21 IS - 3 Suppl N2 - Strict medication adherence is integral to the success of highly active antiretroviral therapies (HAART) in patients with HIV. Research has examined several predictors of adherence, but few studies have examined the association between current smoking, which is highly prevalent among people living with HIV, and medication adherence; moreover, no study has examined the mediating role of depressive symptoms, which may influence both smoking and adherence. Therefore, we recruited 168 patients who were prescribed HAART and assessed viral load, CD4+ count, cigarette smoking, past week and 3-month medication adherence, and depressive symptoms. Results showed that 70% smoked at least one cigarette per day. As predicted, smoking was associated with poorer past week and 3-month adherence, and more depressive symptoms. Regression analyses provided partial support for the hypothesis that depressive symptoms mediated nonadherence among smokers. We conclude that future smoking cessation interventions with this population should target medical adherence and depression as intervention components. SN - 1943-2755 UR - https://www.unboundmedicine.com/medline/citation/19537957/Medication_adherence_in_HIV_infected_smokers:_the_mediating_role_of_depressive_symptoms_ L2 - http://guilfordjournals.com/doi/full/10.1521/aeap.2009.21.3_supp.94 DB - PRIME DP - Unbound Medicine ER -