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Controlled release study of 5-fluorouracil-loaded chitosan/polyethylene glycol microparticles.
Drug Deliv. 2009 Jul; 16(5):274-9.DD

Abstract

The aim of this research is to reduce the frequency of taking therapeutic drugs. Thus, anti-cancer drug [5-fluorourical (5-FU)] loaded chitosan/polyethylene glycol microparticles were prepared by a phase-inversion technique with tripolyphosphate (TPP) used as a cross-linking agent. The relationships between 5-FU release behavior/encapsulation efficiencies and chitosan concentrations, TPP concentrations, as well as cross-linking time were studied to identify better/superior conditions (3.5 wt% chitosan, 3 wt% TPP, and cross-linking time = 4 h) for preparing 5-FU-loaded microparticles. Furthermore, in order to ascertain the influence of their physical properties on 5-FU release performance, 5-FU-loaded microparticles were evaluated by swelling tests and scanning electron microscopy.

Authors+Show Affiliations

Department of Chemical & Materials Engineering, National Yunlin University of Science and Technology, Yunlin, Taiwan. linchuen@yuntech.edu.twNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19538009

Citation

Lin, Chuen-Chang, and Chun-Hsien Fu. "Controlled Release Study of 5-fluorouracil-loaded Chitosan/polyethylene Glycol Microparticles." Drug Delivery, vol. 16, no. 5, 2009, pp. 274-9.
Lin CC, Fu CH. Controlled release study of 5-fluorouracil-loaded chitosan/polyethylene glycol microparticles. Drug Deliv. 2009;16(5):274-9.
Lin, C. C., & Fu, C. H. (2009). Controlled release study of 5-fluorouracil-loaded chitosan/polyethylene glycol microparticles. Drug Delivery, 16(5), 274-9. https://doi.org/10.1080/10717540902987625
Lin CC, Fu CH. Controlled Release Study of 5-fluorouracil-loaded Chitosan/polyethylene Glycol Microparticles. Drug Deliv. 2009;16(5):274-9. PubMed PMID: 19538009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled release study of 5-fluorouracil-loaded chitosan/polyethylene glycol microparticles. AU - Lin,Chuen-Chang, AU - Fu,Chun-Hsien, PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2009/9/26/medline SP - 274 EP - 9 JF - Drug delivery JO - Drug Deliv VL - 16 IS - 5 N2 - The aim of this research is to reduce the frequency of taking therapeutic drugs. Thus, anti-cancer drug [5-fluorourical (5-FU)] loaded chitosan/polyethylene glycol microparticles were prepared by a phase-inversion technique with tripolyphosphate (TPP) used as a cross-linking agent. The relationships between 5-FU release behavior/encapsulation efficiencies and chitosan concentrations, TPP concentrations, as well as cross-linking time were studied to identify better/superior conditions (3.5 wt% chitosan, 3 wt% TPP, and cross-linking time = 4 h) for preparing 5-FU-loaded microparticles. Furthermore, in order to ascertain the influence of their physical properties on 5-FU release performance, 5-FU-loaded microparticles were evaluated by swelling tests and scanning electron microscopy. SN - 1521-0464 UR - https://www.unboundmedicine.com/medline/citation/19538009/Controlled_release_study_of_5_fluorouracil_loaded_chitosan/polyethylene_glycol_microparticles_ L2 - https://www.tandfonline.com/doi/full/10.1080/10717540902987625 DB - PRIME DP - Unbound Medicine ER -