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Human fatality associated with Pacific ciguatoxin contaminated fish.
Toxicon. 2010 Oct; 56(5):668-73.T

Abstract

Ciguatera is a food poisoning identified as the principal risk factor in the consumption of tropical fish in Oceania. The syndrome, which follows ingestion of ciguatoxin-contaminated ciguateric fishes, is characterised by an array of gastrointestinal and neurological features. In this report we examine forensic samples associated with a human fatality using a (3)H-brevetoxin binding assay and reversed-phase HPLC/MS and HPLC/MS/MS. Three Pacific ciguatoxins (P-CTX) were detected in the implicated fish flesh sample by LC-MS/MS, implicating multiple P-CTXs in the fatal case. Additionally, ciguatoxin was identified in a liver sample obtained at post-mortem. The level of ciguatoxin detected (0.14 ppb P-CTX-1 equivalents by binding assay) indicated that at least 10% of the ingested P-CTX-1 remained in the human liver 6 days after the toxic fish was consumed. This study confirms the potential of tropical reef fish to accumulate sufficient P-CTX to be lethal to humans, especially if the liver and viscera are consumed as part of the meal.

Authors+Show Affiliations

The Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, Queensland, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19538985

Citation

Hamilton, Brett, et al. "Human Fatality Associated With Pacific Ciguatoxin Contaminated Fish." Toxicon : Official Journal of the International Society On Toxinology, vol. 56, no. 5, 2010, pp. 668-73.
Hamilton B, Whittle N, Shaw G, et al. Human fatality associated with Pacific ciguatoxin contaminated fish. Toxicon. 2010;56(5):668-73.
Hamilton, B., Whittle, N., Shaw, G., Eaglesham, G., Moore, M. R., & Lewis, R. J. (2010). Human fatality associated with Pacific ciguatoxin contaminated fish. Toxicon : Official Journal of the International Society On Toxinology, 56(5), 668-73. https://doi.org/10.1016/j.toxicon.2009.06.007
Hamilton B, et al. Human Fatality Associated With Pacific Ciguatoxin Contaminated Fish. Toxicon. 2010;56(5):668-73. PubMed PMID: 19538985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human fatality associated with Pacific ciguatoxin contaminated fish. AU - Hamilton,Brett, AU - Whittle,Nigel, AU - Shaw,Glen, AU - Eaglesham,Geoff, AU - Moore,Michael R, AU - Lewis,Richard J, Y1 - 2009/06/16/ PY - 2009/04/06/received PY - 2009/05/29/revised PY - 2009/06/04/accepted PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2010/12/25/medline SP - 668 EP - 73 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 56 IS - 5 N2 - Ciguatera is a food poisoning identified as the principal risk factor in the consumption of tropical fish in Oceania. The syndrome, which follows ingestion of ciguatoxin-contaminated ciguateric fishes, is characterised by an array of gastrointestinal and neurological features. In this report we examine forensic samples associated with a human fatality using a (3)H-brevetoxin binding assay and reversed-phase HPLC/MS and HPLC/MS/MS. Three Pacific ciguatoxins (P-CTX) were detected in the implicated fish flesh sample by LC-MS/MS, implicating multiple P-CTXs in the fatal case. Additionally, ciguatoxin was identified in a liver sample obtained at post-mortem. The level of ciguatoxin detected (0.14 ppb P-CTX-1 equivalents by binding assay) indicated that at least 10% of the ingested P-CTX-1 remained in the human liver 6 days after the toxic fish was consumed. This study confirms the potential of tropical reef fish to accumulate sufficient P-CTX to be lethal to humans, especially if the liver and viscera are consumed as part of the meal. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/19538985/Human_fatality_associated_with_Pacific_ciguatoxin_contaminated_fish_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(09)00300-6 DB - PRIME DP - Unbound Medicine ER -