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Comparison of fatty acid contents of erythrocyte membrane in hemodialysis and peritoneal dialysis patients.
J Ren Nutr. 2009 Jul; 19(4):267-74.JR

Abstract

OBJECTIVE

Membrane fatty acid composition plays an important role in the cellular function. Erythrocyte fatty acid composition mirrors that of myocardium and is influenced by diet. Earlier studies have shown significant alterations of membrane fatty acid composition in ethnically mixed patients with end-stage renal disease. Given the impact of ethnic and dietary factors, we sought to examine membrane fatty acid composition in an ethnically homogeneous end-stage renal disease population residing in a coastal region of Korea with high fish consumption.

DESIGN

Cross-sectional study.

SETTING

Outpatient facility at Dong-A University Hospital, Busan, Republic of Korea.

PATIENTS

We recruited 15 stable hemodialysis patients, 14 peritoneal dialysis patients, and 10 age- and gender-matched normal controls. Patients with significant malnutrition, short duration of dialysis, recent infection, malignancy, or liver disease were excluded. Dietary intake and use of omega-3 fatty acid supplements were determined.

MAIN OUTCOME MEASURE

Erythrocyte membrane fatty acid contents measured by gas chromatography.

RESULTS

Palmitoleic acid and alpha-linolenic acid levels were lower, whereas oleic acid, linoleic acid, and arachidonic acid levels were higher in patients with end-stage renal disease compared with the control group. Total monounsaturated fatty acids (palmitoleic acid and oleic acid) were significantly higher in peritoneal dialysis than in hemodialysis patients. Eicosapentaenoic acid and omega-3 docosapentaenoic acid were significantly higher, but total omega-6 fatty acids, omega-6/omega-3, and arachidonic acid/eicosapentaenoic acid ratios were significantly lower in hemodialysis patients consuming omega-3 supplements compared with those who did not.

CONCLUSION

Patients with end-stage renal disease exhibited significant alterations in erythrocyte membrane fatty acids, which were partially modified by the dialysis modality and omega-3 fatty acid supplementation.

Authors+Show Affiliations

Department of Internal Medicine, Dong-A University, Busan, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19539181

Citation

An, W S., et al. "Comparison of Fatty Acid Contents of Erythrocyte Membrane in Hemodialysis and Peritoneal Dialysis Patients." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 19, no. 4, 2009, pp. 267-74.
An WS, Kim SE, Kim KH, et al. Comparison of fatty acid contents of erythrocyte membrane in hemodialysis and peritoneal dialysis patients. J Ren Nutr. 2009;19(4):267-74.
An, W. S., Kim, S. E., Kim, K. H., Lee, S., Park, Y., Kim, H. J., & Vaziri, N. D. (2009). Comparison of fatty acid contents of erythrocyte membrane in hemodialysis and peritoneal dialysis patients. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 19(4), 267-74. https://doi.org/10.1053/j.jrn.2009.01.027
An WS, et al. Comparison of Fatty Acid Contents of Erythrocyte Membrane in Hemodialysis and Peritoneal Dialysis Patients. J Ren Nutr. 2009;19(4):267-74. PubMed PMID: 19539181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of fatty acid contents of erythrocyte membrane in hemodialysis and peritoneal dialysis patients. AU - An,W S, AU - Kim,S E, AU - Kim,K H, AU - Lee,S, AU - Park,Y, AU - Kim,H J, AU - Vaziri,N D, PY - 2008/03/21/received PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2009/8/28/medline SP - 267 EP - 74 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 19 IS - 4 N2 - OBJECTIVE: Membrane fatty acid composition plays an important role in the cellular function. Erythrocyte fatty acid composition mirrors that of myocardium and is influenced by diet. Earlier studies have shown significant alterations of membrane fatty acid composition in ethnically mixed patients with end-stage renal disease. Given the impact of ethnic and dietary factors, we sought to examine membrane fatty acid composition in an ethnically homogeneous end-stage renal disease population residing in a coastal region of Korea with high fish consumption. DESIGN: Cross-sectional study. SETTING: Outpatient facility at Dong-A University Hospital, Busan, Republic of Korea. PATIENTS: We recruited 15 stable hemodialysis patients, 14 peritoneal dialysis patients, and 10 age- and gender-matched normal controls. Patients with significant malnutrition, short duration of dialysis, recent infection, malignancy, or liver disease were excluded. Dietary intake and use of omega-3 fatty acid supplements were determined. MAIN OUTCOME MEASURE: Erythrocyte membrane fatty acid contents measured by gas chromatography. RESULTS: Palmitoleic acid and alpha-linolenic acid levels were lower, whereas oleic acid, linoleic acid, and arachidonic acid levels were higher in patients with end-stage renal disease compared with the control group. Total monounsaturated fatty acids (palmitoleic acid and oleic acid) were significantly higher in peritoneal dialysis than in hemodialysis patients. Eicosapentaenoic acid and omega-3 docosapentaenoic acid were significantly higher, but total omega-6 fatty acids, omega-6/omega-3, and arachidonic acid/eicosapentaenoic acid ratios were significantly lower in hemodialysis patients consuming omega-3 supplements compared with those who did not. CONCLUSION: Patients with end-stage renal disease exhibited significant alterations in erythrocyte membrane fatty acids, which were partially modified by the dialysis modality and omega-3 fatty acid supplementation. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/19539181/Comparison_of_fatty_acid_contents_of_erythrocyte_membrane_in_hemodialysis_and_peritoneal_dialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(09)00049-1 DB - PRIME DP - Unbound Medicine ER -