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IL-18 in induced sputum and airway hyperresponsiveness in mild asthmatics: effect of smoking.
Respir Med. 2009 Dec; 103(12):1919-25.RM

Abstract

Interleukin 18 (IL-18) is a pro-inflammatory cytokine, which has been shown to be implicated in the induction of airway hyperresponsiveness (AHR) in murine asthma models. The association of IL-18 with AHR in human bronchial asthma is not clear as yet. As cigarette smoking modifies airway inflammation we aimed to assess the relationship of IL-18 with airway hyperresponsiveness (AHR) in non-smoking versus smoking asthmatics. IL-18 was measured in sputum supernatants obtained from asthmatic (24 smokers and 22 non-smokers) and healthy subjects (16 smokers and 17 non-smokers). All subjects were assessed by spirometry, skin-prick tests to common aeroallergens and bronchial provocation to methacholine (Mch). There was no significant difference in IL-18 levels between healthy and asthmatic smokers and between healthy and asthmatic non-smokers. IL-18 levels in sputum were significantly lower in healthy smokers compared to non-smokers (p=0.048); similarly, in asthmatic smokers as compared to non-smokers (p=0.037). An inverse correlation was found between IL-18 levels, FEV(1) (% pred) (r=-0.495, p=0.043), and PD(20)Mc(h) in non-smoking asthmatics (r=-0.621, p=0.024). A positive correlation was found in smoking asthmatics between IL-18 levels in sputum and FEV(1) (% pred) (r=0.627, p=0.002), FVC (% pred) (r=0.460, p=0.031), and PD(20)Mc(h) (r=0.809, p=0.005). Cigarette smoking reduced IL-18 levels in induced sputum in healthy and asthmatic smokers. IL-18 levels were correlated with airway obstruction and AHR in an inverse way in smoking and non-smoking asthmatics. These results suggest the implication of IL-18 in airway hyperresponsiveness characterizing bronchial asthma, which is modified by smoking.

Authors+Show Affiliations

Sotiria Hospital for Diseases of the Chest, Department of Respiratory Medicine, University of Athens, Medical School, Athens, Greece. nikrovina@med.uoa.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19539457

Citation

Rovina, Nikoletta, et al. "IL-18 in Induced Sputum and Airway Hyperresponsiveness in Mild Asthmatics: Effect of Smoking." Respiratory Medicine, vol. 103, no. 12, 2009, pp. 1919-25.
Rovina N, Dima E, Gerassimou C, et al. IL-18 in induced sputum and airway hyperresponsiveness in mild asthmatics: effect of smoking. Respir Med. 2009;103(12):1919-25.
Rovina, N., Dima, E., Gerassimou, C., Kollintza, A., Gratziou, C., & Roussos, C. (2009). IL-18 in induced sputum and airway hyperresponsiveness in mild asthmatics: effect of smoking. Respiratory Medicine, 103(12), 1919-25. https://doi.org/10.1016/j.rmed.2009.05.023
Rovina N, et al. IL-18 in Induced Sputum and Airway Hyperresponsiveness in Mild Asthmatics: Effect of Smoking. Respir Med. 2009;103(12):1919-25. PubMed PMID: 19539457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IL-18 in induced sputum and airway hyperresponsiveness in mild asthmatics: effect of smoking. AU - Rovina,Nikoletta, AU - Dima,Efrossini, AU - Gerassimou,Christina, AU - Kollintza,Androniki, AU - Gratziou,Christina, AU - Roussos,Charis, Y1 - 2009/06/17/ PY - 2009/03/16/received PY - 2009/05/13/revised PY - 2009/05/26/accepted PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2010/3/5/medline SP - 1919 EP - 25 JF - Respiratory medicine JO - Respir Med VL - 103 IS - 12 N2 - Interleukin 18 (IL-18) is a pro-inflammatory cytokine, which has been shown to be implicated in the induction of airway hyperresponsiveness (AHR) in murine asthma models. The association of IL-18 with AHR in human bronchial asthma is not clear as yet. As cigarette smoking modifies airway inflammation we aimed to assess the relationship of IL-18 with airway hyperresponsiveness (AHR) in non-smoking versus smoking asthmatics. IL-18 was measured in sputum supernatants obtained from asthmatic (24 smokers and 22 non-smokers) and healthy subjects (16 smokers and 17 non-smokers). All subjects were assessed by spirometry, skin-prick tests to common aeroallergens and bronchial provocation to methacholine (Mch). There was no significant difference in IL-18 levels between healthy and asthmatic smokers and between healthy and asthmatic non-smokers. IL-18 levels in sputum were significantly lower in healthy smokers compared to non-smokers (p=0.048); similarly, in asthmatic smokers as compared to non-smokers (p=0.037). An inverse correlation was found between IL-18 levels, FEV(1) (% pred) (r=-0.495, p=0.043), and PD(20)Mc(h) in non-smoking asthmatics (r=-0.621, p=0.024). A positive correlation was found in smoking asthmatics between IL-18 levels in sputum and FEV(1) (% pred) (r=0.627, p=0.002), FVC (% pred) (r=0.460, p=0.031), and PD(20)Mc(h) (r=0.809, p=0.005). Cigarette smoking reduced IL-18 levels in induced sputum in healthy and asthmatic smokers. IL-18 levels were correlated with airway obstruction and AHR in an inverse way in smoking and non-smoking asthmatics. These results suggest the implication of IL-18 in airway hyperresponsiveness characterizing bronchial asthma, which is modified by smoking. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/19539457/IL_18_in_induced_sputum_and_airway_hyperresponsiveness_in_mild_asthmatics:_effect_of_smoking_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(09)00186-3 DB - PRIME DP - Unbound Medicine ER -