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Can recreational doses of THC produce significant dopamine release in the human striatum?
Neuroimage 2009; 48(1):186-90N

Abstract

BACKGROUND

Cannabis use in early adolescence may be a risk factor for development of schizophrenia. In animals, Delta9-tetrahydrocannabinol (THC) increases the rate of dopamine neuronal firing and release in the striatum. Thus cannabis use may increase dopamine release in the human striatum leading to vulnerability to psychosis.

AIMS

To investigate whether THC, the main psychoactive component of cannabis, can produce dopamine release in the human striatum.

METHODS

Thirteen healthy volunteers, with previous cannabis experience, underwent two [11C]-raclopride positron emission tomography (PET) scans to indirectly measure striatal dopamine levels following either 10 mg THC or placebo.

RESULTS

Although THC markedly increased psychosis-like symptoms on the Psychotomimetic States Inventory (PSI), there was no significant effect of THC on [11C]-raclopride binding.

CONCLUSION

In the largest study of its kind so far, we have shown that recreational cannabis users do not release significant amounts of dopamine from an oral THC dose equivalent to a standard cannabis cigarette. This result challenges current models of striatal dopamine release as the mechanism mediating cannabis as risk factor for schizophrenia.

Authors+Show Affiliations

Psychiatry Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, UK. paul.stokes@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19539765

Citation

Stokes, Paul R A., et al. "Can Recreational Doses of THC Produce Significant Dopamine Release in the Human Striatum?" NeuroImage, vol. 48, no. 1, 2009, pp. 186-90.
Stokes PR, Mehta MA, Curran HV, et al. Can recreational doses of THC produce significant dopamine release in the human striatum? Neuroimage. 2009;48(1):186-90.
Stokes, P. R., Mehta, M. A., Curran, H. V., Breen, G., & Grasby, P. M. (2009). Can recreational doses of THC produce significant dopamine release in the human striatum? NeuroImage, 48(1), pp. 186-90. doi:10.1016/j.neuroimage.2009.06.029.
Stokes PR, et al. Can Recreational Doses of THC Produce Significant Dopamine Release in the Human Striatum. Neuroimage. 2009 Oct 15;48(1):186-90. PubMed PMID: 19539765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can recreational doses of THC produce significant dopamine release in the human striatum? AU - Stokes,Paul R A, AU - Mehta,Mitul A, AU - Curran,H Valerie, AU - Breen,Gerome, AU - Grasby,Paul M, Y1 - 2009/06/17/ PY - 2009/05/06/received PY - 2009/06/10/revised PY - 2009/06/12/accepted PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2009/10/27/medline SP - 186 EP - 90 JF - NeuroImage JO - Neuroimage VL - 48 IS - 1 N2 - BACKGROUND: Cannabis use in early adolescence may be a risk factor for development of schizophrenia. In animals, Delta9-tetrahydrocannabinol (THC) increases the rate of dopamine neuronal firing and release in the striatum. Thus cannabis use may increase dopamine release in the human striatum leading to vulnerability to psychosis. AIMS: To investigate whether THC, the main psychoactive component of cannabis, can produce dopamine release in the human striatum. METHODS: Thirteen healthy volunteers, with previous cannabis experience, underwent two [11C]-raclopride positron emission tomography (PET) scans to indirectly measure striatal dopamine levels following either 10 mg THC or placebo. RESULTS: Although THC markedly increased psychosis-like symptoms on the Psychotomimetic States Inventory (PSI), there was no significant effect of THC on [11C]-raclopride binding. CONCLUSION: In the largest study of its kind so far, we have shown that recreational cannabis users do not release significant amounts of dopamine from an oral THC dose equivalent to a standard cannabis cigarette. This result challenges current models of striatal dopamine release as the mechanism mediating cannabis as risk factor for schizophrenia. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/19539765/full_citation/Can_recreational_doses_of_THC_produce_significant_dopamine_release_in_the_human_striatum L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(09)00664-8 DB - PRIME DP - Unbound Medicine ER -