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Alzheimer's disease, metal ions and metal homeostatic therapy.
Trends Pharmacol Sci 2009; 30(7):346-55TP

Abstract

Mounting evidences support the idea that endogenous 'biometals', such as copper, iron, zinc and exogenous ones such as aluminum, can be involved as factors or cofactors in the etiopathogenesis of a variety of neurodegenerative diseases. Alzheimer's disease (AD) is a multifactorial neurodegenerative condition associated with pathological accumulation of amyloid plaques and with the appearance of deposit of neurofibrillary tangles. In AD, the process of beta-amyloid (Abeta) misfolding and plaque aggregation is greatly influenced by alterations in the homeostasis of the aforementioned metal ions. Here, we discuss the most recent evidences that associate metal ion dyshomeostasis with the development of AD. As for aluminum, a role for this ion in AD pathogenesis is still controversial. Thus, here, we also critically review new findings that argue for and against the 'aluminum hypothesis'. Finally, it is discussed how therapeutic strategies aimed at restoring metal homeostasis can delay and modify the progression of AD-related neurodegeneration.

Authors+Show Affiliations

CNR-Institute for Biomedical Technologies, Padua 'Metalloproteins' Unit, Department of Biology, University of Padua, Viale G. Colombo 3-35121 Padua, Italy. zatta@mail.bio.unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19540003

Citation

Zatta, Paolo, et al. "Alzheimer's Disease, Metal Ions and Metal Homeostatic Therapy." Trends in Pharmacological Sciences, vol. 30, no. 7, 2009, pp. 346-55.
Zatta P, Drago D, Bolognin S, et al. Alzheimer's disease, metal ions and metal homeostatic therapy. Trends Pharmacol Sci. 2009;30(7):346-55.
Zatta, P., Drago, D., Bolognin, S., & Sensi, S. L. (2009). Alzheimer's disease, metal ions and metal homeostatic therapy. Trends in Pharmacological Sciences, 30(7), pp. 346-55. doi:10.1016/j.tips.2009.05.002.
Zatta P, et al. Alzheimer's Disease, Metal Ions and Metal Homeostatic Therapy. Trends Pharmacol Sci. 2009;30(7):346-55. PubMed PMID: 19540003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alzheimer's disease, metal ions and metal homeostatic therapy. AU - Zatta,Paolo, AU - Drago,Denise, AU - Bolognin,Silvia, AU - Sensi,Stefano L, Y1 - 2009/06/17/ PY - 2009/01/30/received PY - 2009/04/15/revised PY - 2009/05/06/accepted PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2011/8/4/medline SP - 346 EP - 55 JF - Trends in pharmacological sciences JO - Trends Pharmacol. Sci. VL - 30 IS - 7 N2 - Mounting evidences support the idea that endogenous 'biometals', such as copper, iron, zinc and exogenous ones such as aluminum, can be involved as factors or cofactors in the etiopathogenesis of a variety of neurodegenerative diseases. Alzheimer's disease (AD) is a multifactorial neurodegenerative condition associated with pathological accumulation of amyloid plaques and with the appearance of deposit of neurofibrillary tangles. In AD, the process of beta-amyloid (Abeta) misfolding and plaque aggregation is greatly influenced by alterations in the homeostasis of the aforementioned metal ions. Here, we discuss the most recent evidences that associate metal ion dyshomeostasis with the development of AD. As for aluminum, a role for this ion in AD pathogenesis is still controversial. Thus, here, we also critically review new findings that argue for and against the 'aluminum hypothesis'. Finally, it is discussed how therapeutic strategies aimed at restoring metal homeostasis can delay and modify the progression of AD-related neurodegeneration. SN - 1873-3735 UR - https://www.unboundmedicine.com/medline/citation/19540003/Alzheimer's_disease_metal_ions_and_metal_homeostatic_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-6147(09)00088-1 DB - PRIME DP - Unbound Medicine ER -