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Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function.
Clin J Am Soc Nephrol. 2009 Aug; 4(8):1302-11.CJ

Abstract

BACKGROUND AND OBJECTIVES

The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for the progression of chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with CKD. We examined baseline demographic and clinical characteristics.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

Seven clinical centers recruited adults who were aged 21 to 74 yr and had CKD using age-based estimated GFR (eGFR) inclusion criteria. At baseline, blood and urine specimens were collected and information regarding health behaviors, diet, quality of life, and functional status was obtained. GFR was measured using radiolabeled iothalamate in one third of participants.

RESULTS

A total of 3612 participants were enrolled with mean age +/- SD of 58.2 +/- 11.0 yr; 46% were women, and 47% had diabetes. Overall, 45% were non-Hispanic white, 46% were non-Hispanic black, and 5% were Hispanic. Eighty-six percent reported hypertension, 22% coronary disease, and 10% heart failure. Mean body mass index was 32.1 +/- 7.9 kg/m(2), and 47% had a BP >130/80 mmHg. Mean eGFR was 43.4 +/- 13.5 ml/min per 1.73 m(2), and median (interquartile range) protein excretion was 0.17 g/24 h (0.07 to 0.81 g/24 h). Lower eGFR was associated with older age, lower socioeconomic and educational level, cigarette smoking, self-reported CVD, peripheral arterial disease, and elevated BP.

CONCLUSIONS

Lower level of eGFR was associated with a greater burden of CVD as well as lower socioeconomic and educational status. Long-term follow-up of participants will provide critical insights into the epidemiology of CKD and its relationship to adverse outcomes.

Links

Publisher Full Text
ncbi.nlm.nih.gov
cjasn.asnjournals.org
PMC Free PDF

Authors+Show Affiliations

Lash JP
University of Illinois at Chicago, Department of Medicine/Section of Nephrology (MC 793), 820 South Wood Street, Chicago, IL 60612-7315, USA. jplash@uic.edu
Go AS
No affiliation info available
Appel LJ
No affiliation info available
He J
No affiliation info available
Ojo A
No affiliation info available
Rahman M
No affiliation info available
Townsend RR
No affiliation info available
Xie D
No affiliation info available
Cifelli D
No affiliation info available
Cohan J
No affiliation info available
Fink JC
No affiliation info available
Fischer MJ
No affiliation info available
Gadegbeku C
No affiliation info available
Hamm LL
No affiliation info available
Kusek JW
No affiliation info available
Landis JR
No affiliation info available
Narva A
No affiliation info available
Robinson N
No affiliation info available
Teal V
No affiliation info available
Feldman HI
No affiliation info available
Chronic Renal Insufficiency Cohort (CRIC) Study Group
No affiliation info available

MeSH

AdultAge FactorsAgedBlood PressureCardiovascular DiseasesDisease ProgressionEducational StatusFemaleGlomerular Filtration RateHumansKidneyKidney Failure, ChronicMaleMiddle AgedPatient SelectionProspective StudiesProteinuriaRenal Insufficiency, ChronicRisk AssessmentRisk FactorsSmokingSocial ClassUnited StatesYoung Adult

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19541818

Clinical Trial Links

Clinical trial which this article describes

Citation

Lash, James P., et al. "Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations With Kidney Function." Clinical Journal of the American Society of Nephrology : CJASN, vol. 4, no. 8, 2009, pp. 1302-11.
Lash JP, Go AS, Appel LJ, et al. Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function. Clin J Am Soc Nephrol. 2009;4(8):1302-11.
Lash, J. P., Go, A. S., Appel, L. J., He, J., Ojo, A., Rahman, M., Townsend, R. R., Xie, D., Cifelli, D., Cohan, J., Fink, J. C., Fischer, M. J., Gadegbeku, C., Hamm, L. L., Kusek, J. W., Landis, J. R., Narva, A., Robinson, N., Teal, V., & Feldman, H. I. (2009). Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function. Clinical Journal of the American Society of Nephrology : CJASN, 4(8), 1302-11. https://doi.org/10.2215/CJN.00070109
Lash JP, et al. Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations With Kidney Function. Clin J Am Soc Nephrol. 2009;4(8):1302-11. PubMed PMID: 19541818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function. AU - Lash,James P, AU - Go,Alan S, AU - Appel,Lawrence J, AU - He,Jiang, AU - Ojo,Akinlolu, AU - Rahman,Mahboob, AU - Townsend,Raymond R, AU - Xie,Dawei, AU - Cifelli,Denise, AU - Cohan,Janet, AU - Fink,Jeffrey C, AU - Fischer,Michael J, AU - Gadegbeku,Crystal, AU - Hamm,L Lee, AU - Kusek,John W, AU - Landis,J Richard, AU - Narva,Andrew, AU - Robinson,Nancy, AU - Teal,Valerie, AU - Feldman,Harold I, AU - ,, Y1 - 2009/06/18/ PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2009/10/16/medline SP - 1302 EP - 11 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 4 IS - 8 N2 - BACKGROUND AND OBJECTIVES: The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for the progression of chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with CKD. We examined baseline demographic and clinical characteristics. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Seven clinical centers recruited adults who were aged 21 to 74 yr and had CKD using age-based estimated GFR (eGFR) inclusion criteria. At baseline, blood and urine specimens were collected and information regarding health behaviors, diet, quality of life, and functional status was obtained. GFR was measured using radiolabeled iothalamate in one third of participants. RESULTS: A total of 3612 participants were enrolled with mean age +/- SD of 58.2 +/- 11.0 yr; 46% were women, and 47% had diabetes. Overall, 45% were non-Hispanic white, 46% were non-Hispanic black, and 5% were Hispanic. Eighty-six percent reported hypertension, 22% coronary disease, and 10% heart failure. Mean body mass index was 32.1 +/- 7.9 kg/m(2), and 47% had a BP >130/80 mmHg. Mean eGFR was 43.4 +/- 13.5 ml/min per 1.73 m(2), and median (interquartile range) protein excretion was 0.17 g/24 h (0.07 to 0.81 g/24 h). Lower eGFR was associated with older age, lower socioeconomic and educational level, cigarette smoking, self-reported CVD, peripheral arterial disease, and elevated BP. CONCLUSIONS: Lower level of eGFR was associated with a greater burden of CVD as well as lower socioeconomic and educational status. Long-term follow-up of participants will provide critical insights into the epidemiology of CKD and its relationship to adverse outcomes. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/19541818/Chronic_Renal_Insufficiency_Cohort__CRIC__Study:_baseline_characteristics_and_associations_with_kidney_function_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=19541818 DB - PRIME DP - Unbound Medicine ER -