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Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health Study.
Am J Epidemiol 2009; 170(3):308-17AJ

Abstract

Little is known about the association between alcohol and breast cancer by different tumor characteristics. The study consisted of 184,418 postmenopausal women aged 50-71 years in the National Institutes of Health-AARP Diet and Health Study (1995-2003). Alcohol use, diet, and potential risk factors for cancer were assessed with a mailed questionnaire at baseline. The relative risks and 95% confidence intervals were estimated by using Cox proportional hazards regression. Breast cancer cases and estrogen receptor and progesterone receptor status were identified through linkage to state cancer registries. During an average of 7 years of follow-up, 5,461 breast cancer cases were identified. Alcohol was significantly positively associated with total breast cancer: Even a moderate amount of alcohol (>10 g/day) significantly increased breast cancer risk. In a comparison of >35 g versus 0 g/day, the multivariate relative risks were 1.35 (95% confidence interval (CI): 1.17, 1.56) for total breast cancer, 1.46 (95% CI: 1.22, 1.75) for ductal tumors, and 1.52 (95% CI: 0.95, 2.44) for lobular tumors. The multivariate relative risks for estrogen receptor-positive/progesterone receptor-positive, estrogen receptor-positive/progesterone receptor-negative, and estrogen receptor-negative/progesterone receptor-negative tumors were 1.46 (95% CI: 1.12, 1.91) for >35 g versus 0 g/day, 1.13 (95% CI: 0.73, 1.77) for >20 g versus 0 g/day, and 1.21 (95% CI: 0.79, 1.84) for >20 g versus 0 g/day, respectively. Moderate consumption of alcohol was associated with breast cancer, specifically hormone receptor-positive tumors.

Authors+Show Affiliations

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, MD 20852, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

19541857

Citation

Lew, Jasmine Q., et al. "Alcohol and Risk of Breast Cancer By Histologic Type and Hormone Receptor Status in Postmenopausal Women: the NIH-AARP Diet and Health Study." American Journal of Epidemiology, vol. 170, no. 3, 2009, pp. 308-17.
Lew JQ, Freedman ND, Leitzmann MF, et al. Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health Study. Am J Epidemiol. 2009;170(3):308-17.
Lew, J. Q., Freedman, N. D., Leitzmann, M. F., Brinton, L. A., Hoover, R. N., Hollenbeck, A. R., ... Park, Y. (2009). Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health Study. American Journal of Epidemiology, 170(3), pp. 308-17. doi:10.1093/aje/kwp120.
Lew JQ, et al. Alcohol and Risk of Breast Cancer By Histologic Type and Hormone Receptor Status in Postmenopausal Women: the NIH-AARP Diet and Health Study. Am J Epidemiol. 2009 Aug 1;170(3):308-17. PubMed PMID: 19541857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health Study. AU - Lew,Jasmine Q, AU - Freedman,Neal D, AU - Leitzmann,Michael F, AU - Brinton,Louise A, AU - Hoover,Robert N, AU - Hollenbeck,Albert R, AU - Schatzkin,Arthur, AU - Park,Yikyung, Y1 - 2009/06/18/ PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2009/8/14/medline SP - 308 EP - 17 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 170 IS - 3 N2 - Little is known about the association between alcohol and breast cancer by different tumor characteristics. The study consisted of 184,418 postmenopausal women aged 50-71 years in the National Institutes of Health-AARP Diet and Health Study (1995-2003). Alcohol use, diet, and potential risk factors for cancer were assessed with a mailed questionnaire at baseline. The relative risks and 95% confidence intervals were estimated by using Cox proportional hazards regression. Breast cancer cases and estrogen receptor and progesterone receptor status were identified through linkage to state cancer registries. During an average of 7 years of follow-up, 5,461 breast cancer cases were identified. Alcohol was significantly positively associated with total breast cancer: Even a moderate amount of alcohol (>10 g/day) significantly increased breast cancer risk. In a comparison of >35 g versus 0 g/day, the multivariate relative risks were 1.35 (95% confidence interval (CI): 1.17, 1.56) for total breast cancer, 1.46 (95% CI: 1.22, 1.75) for ductal tumors, and 1.52 (95% CI: 0.95, 2.44) for lobular tumors. The multivariate relative risks for estrogen receptor-positive/progesterone receptor-positive, estrogen receptor-positive/progesterone receptor-negative, and estrogen receptor-negative/progesterone receptor-negative tumors were 1.46 (95% CI: 1.12, 1.91) for >35 g versus 0 g/day, 1.13 (95% CI: 0.73, 1.77) for >20 g versus 0 g/day, and 1.21 (95% CI: 0.79, 1.84) for >20 g versus 0 g/day, respectively. Moderate consumption of alcohol was associated with breast cancer, specifically hormone receptor-positive tumors. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19541857/Alcohol_and_risk_of_breast_cancer_by_histologic_type_and_hormone_receptor_status_in_postmenopausal_women:_the_NIH_AARP_Diet_and_Health_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp120 DB - PRIME DP - Unbound Medicine ER -