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Early daycare is associated with an increase in airway symptoms in early childhood but is no protection against asthma or atopy at 8 years.
Am J Respir Crit Care Med. 2009 Sep 15; 180(6):491-8.AJ

Abstract

RATIONALE

Daycare exposes young children to more infections early in life and may thereby prevent the development of asthma and allergy.

OBJECTIVES

To prospectively study the effect of daycare on the development of asthma and allergic sensitization during the first 8 years of life.

METHODS

In the Prevention and Incidence of Asthma and Mite Allergy birth cohort 3,963 newborn children were followed prospectively for 8 years. Daycare use and respiratory health were assessed yearly by questionnaires. At 8 years, sensitization to airborne allergens and airway responsiveness were measured. Daycare was defined as early (aged 0-2 yr), late (aged 2-4 yr), or none (no daycare before age 4 yr). Associations of daycare and/or older siblings with asthma symptoms (wheezing, shortness of breath, and inhaled steroids taken in the last year), airway responsiveness, and allergic sensitization were assessed in a longitudinal repeated-event analysis.

MEASUREMENTS AND MAIN RESULTS

Children with early daycare had more wheezing in the first years of life, but less wheezing and steroid use between 4 and 8 years of age. At the age of 8 years, early daycare was not protective for asthma symptoms (adjusted odds ratio [aOR], 0.99; 95% confidence interval [CI], 0.74-1.32), allergic sensitization (aOR 0.86; 95% CI, 0.63-1.18), or airway hyperresponsiveness (aOR, 0.80; 95% CI, 0.57-1.14). The transient reduction in airway symptoms between age 4 and 8 years was only observed in children without older siblings.

CONCLUSION

Early daycare is associated with an increase in airway symptoms until the age of 4 years, and fewer symptoms between the ages of 4 and 8 years. We found no protection against asthma symptoms, hyperresponsiveness, or allergic sensitization at the age of 8 years.

Authors+Show Affiliations

Department of Pediatrics/Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19542478

Citation

Caudri, Daan, et al. "Early Daycare Is Associated With an Increase in Airway Symptoms in Early Childhood but Is No Protection Against Asthma or Atopy at 8 Years." American Journal of Respiratory and Critical Care Medicine, vol. 180, no. 6, 2009, pp. 491-8.
Caudri D, Wijga A, Scholtens S, et al. Early daycare is associated with an increase in airway symptoms in early childhood but is no protection against asthma or atopy at 8 years. Am J Respir Crit Care Med. 2009;180(6):491-8.
Caudri, D., Wijga, A., Scholtens, S., Kerkhof, M., Gerritsen, J., Ruskamp, J. M., Brunekreef, B., Smit, H. A., & de Jongste, J. C. (2009). Early daycare is associated with an increase in airway symptoms in early childhood but is no protection against asthma or atopy at 8 years. American Journal of Respiratory and Critical Care Medicine, 180(6), 491-8. https://doi.org/10.1164/rccm.200903-0327OC
Caudri D, et al. Early Daycare Is Associated With an Increase in Airway Symptoms in Early Childhood but Is No Protection Against Asthma or Atopy at 8 Years. Am J Respir Crit Care Med. 2009 Sep 15;180(6):491-8. PubMed PMID: 19542478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early daycare is associated with an increase in airway symptoms in early childhood but is no protection against asthma or atopy at 8 years. AU - Caudri,Daan, AU - Wijga,Alet, AU - Scholtens,Salome, AU - Kerkhof,Marjan, AU - Gerritsen,Jorrit, AU - Ruskamp,Jopje M, AU - Brunekreef,Bert, AU - Smit,Henriette A, AU - de Jongste,Johan C, Y1 - 2009/06/19/ PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2009/10/2/medline SP - 491 EP - 8 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 180 IS - 6 N2 - RATIONALE: Daycare exposes young children to more infections early in life and may thereby prevent the development of asthma and allergy. OBJECTIVES: To prospectively study the effect of daycare on the development of asthma and allergic sensitization during the first 8 years of life. METHODS: In the Prevention and Incidence of Asthma and Mite Allergy birth cohort 3,963 newborn children were followed prospectively for 8 years. Daycare use and respiratory health were assessed yearly by questionnaires. At 8 years, sensitization to airborne allergens and airway responsiveness were measured. Daycare was defined as early (aged 0-2 yr), late (aged 2-4 yr), or none (no daycare before age 4 yr). Associations of daycare and/or older siblings with asthma symptoms (wheezing, shortness of breath, and inhaled steroids taken in the last year), airway responsiveness, and allergic sensitization were assessed in a longitudinal repeated-event analysis. MEASUREMENTS AND MAIN RESULTS: Children with early daycare had more wheezing in the first years of life, but less wheezing and steroid use between 4 and 8 years of age. At the age of 8 years, early daycare was not protective for asthma symptoms (adjusted odds ratio [aOR], 0.99; 95% confidence interval [CI], 0.74-1.32), allergic sensitization (aOR 0.86; 95% CI, 0.63-1.18), or airway hyperresponsiveness (aOR, 0.80; 95% CI, 0.57-1.14). The transient reduction in airway symptoms between age 4 and 8 years was only observed in children without older siblings. CONCLUSION: Early daycare is associated with an increase in airway symptoms until the age of 4 years, and fewer symptoms between the ages of 4 and 8 years. We found no protection against asthma symptoms, hyperresponsiveness, or allergic sensitization at the age of 8 years. SN - 1535-4970 UR - https://www.unboundmedicine.com/medline/citation/19542478/Early_daycare_is_associated_with_an_increase_in_airway_symptoms_in_early_childhood_but_is_no_protection_against_asthma_or_atopy_at_8_years_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.200903-0327OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -