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High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects.
J Alzheimers Dis. 2009; 17(4):921-7.JA

Abstract

A higher daily intake of fruits and vegetables in healthy elderly is associated with an improved antioxidant status in comparison to subjects consuming diets poor in fruits and vegetables, but the impact on cognitive performance is unclear. Healthy community dwellers (45 to 102 years old, n=193) underwent cognitive testing and blood withdrawal for the measurement of antioxidant micronutrients and biomarkers of oxidative stress as well as administration of a food frequency questionnaire to assess the daily intake of fruits and vegetables (high intake HI, low intake LI). Ninety-four subjects of the HI group had significantly higher cognitive test scores, higher levels of carotenoids, alpha- and gamma-tocopherol as well as lower levels of F2 alpha isoprostanes than the 99 subjects of the LI group. Cognitive scores were directly correlated with blood levels of alpha-tocopherol and lycopene and negatively correlated with F2 alpha isoprostanes and protein carbonyls. The results were independent of age, gender, body mass index, education, total cholesterol, LDL- and HDL-cholesterol, triglycerides, and albumin. Healthy subjects of any age with a high daily intake of fruits and vegetables have higher antioxidant levels, lower levels of biomarkers of oxidative stress, and better cognitive performance than healthy subjects of any age consuming low amounts of fruits and vegetables. Modification of nutritional habits aimed at increasing intake of fruits and vegetables should be encouraged to lower prevalence of cognitive impairment in later life.

Authors+Show Affiliations

Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, Düsseldorf, Germany. polidori@uni-duesseldorf.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19542607

Citation

Polidori, M Cristina, et al. "High Fruit and Vegetable Intake Is Positively Correlated With Antioxidant Status and Cognitive Performance in Healthy Subjects." Journal of Alzheimer's Disease : JAD, vol. 17, no. 4, 2009, pp. 921-7.
Polidori MC, Praticó D, Mangialasche F, et al. High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. J Alzheimers Dis. 2009;17(4):921-7.
Polidori, M. C., Praticó, D., Mangialasche, F., Mariani, E., Aust, O., Anlasik, T., Mang, N., Pientka, L., Stahl, W., Sies, H., Mecocci, P., & Nelles, G. (2009). High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. Journal of Alzheimer's Disease : JAD, 17(4), 921-7. https://doi.org/10.3233/JAD-2009-1114
Polidori MC, et al. High Fruit and Vegetable Intake Is Positively Correlated With Antioxidant Status and Cognitive Performance in Healthy Subjects. J Alzheimers Dis. 2009;17(4):921-7. PubMed PMID: 19542607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. AU - Polidori,M Cristina, AU - Praticó,Domenico, AU - Mangialasche,Francesca, AU - Mariani,Elena, AU - Aust,Olivier, AU - Anlasik,Timur, AU - Mang,Ni, AU - Pientka,Ludger, AU - Stahl,Wilhelm, AU - Sies,Helmut, AU - Mecocci,Patrizia, AU - Nelles,Gereon, PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2010/9/24/medline SP - 921 EP - 7 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 17 IS - 4 N2 - A higher daily intake of fruits and vegetables in healthy elderly is associated with an improved antioxidant status in comparison to subjects consuming diets poor in fruits and vegetables, but the impact on cognitive performance is unclear. Healthy community dwellers (45 to 102 years old, n=193) underwent cognitive testing and blood withdrawal for the measurement of antioxidant micronutrients and biomarkers of oxidative stress as well as administration of a food frequency questionnaire to assess the daily intake of fruits and vegetables (high intake HI, low intake LI). Ninety-four subjects of the HI group had significantly higher cognitive test scores, higher levels of carotenoids, alpha- and gamma-tocopherol as well as lower levels of F2 alpha isoprostanes than the 99 subjects of the LI group. Cognitive scores were directly correlated with blood levels of alpha-tocopherol and lycopene and negatively correlated with F2 alpha isoprostanes and protein carbonyls. The results were independent of age, gender, body mass index, education, total cholesterol, LDL- and HDL-cholesterol, triglycerides, and albumin. Healthy subjects of any age with a high daily intake of fruits and vegetables have higher antioxidant levels, lower levels of biomarkers of oxidative stress, and better cognitive performance than healthy subjects of any age consuming low amounts of fruits and vegetables. Modification of nutritional habits aimed at increasing intake of fruits and vegetables should be encouraged to lower prevalence of cognitive impairment in later life. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/19542607/High_fruit_and_vegetable_intake_is_positively_correlated_with_antioxidant_status_and_cognitive_performance_in_healthy_subjects_ L2 - https://content.iospress.com/openurl?genre=article&issn=1387-2877&volume=17&issue=4&spage=921 DB - PRIME DP - Unbound Medicine ER -