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BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study.
J Alzheimers Dis 2009; 17(4):887-98JA

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal survival, growth, and differentiation. The role of BDNF in learning and memory suggests that it may also modulate the clinical course of Alzheimer's disease (AD). This study aimed to determine whether BDNF genetic variants are related to premorbid educational attainment, progression of cognitive and functional decline, and associated neuropsychiatric symptoms in AD patients. A sample of AD subjects (N = 341) was genotyped for the BDNF polymorphisms: Val66Met, C270T, and G-712A. Subjects received tests of cognition and daily function at baseline and at multiple subsequent time points. They were also characterized for the frequency and severity of neuropsychiatric symptoms. There was a significant effect of Val66Met genotype on educational attainment (F = 7.49, df = 2,329, P = 0.00066), with Met/Met homozygotes having significantly lower education than both the Val/Met and Val/Val groups. No association was observed between any BDNF polymorphism and measures of cognitive or functional decline. The T-allele of the C270T polymorphism was associated with a higher prevalence of neuropsychiatric symptoms and specifically with the presence of hallucinations. The effect of the Val66Met polymorphism on premorbid educational attainment is intriguing and should be verified in a larger sample.

Authors+Show Affiliations

Alzheimer's Disease Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19542613

Citation

Zdanys, Kristina F., et al. "BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: an Exploratory Study." Journal of Alzheimer's Disease : JAD, vol. 17, no. 4, 2009, pp. 887-98.
Zdanys KF, Kleiman TG, Zhang H, et al. BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study. J Alzheimers Dis. 2009;17(4):887-98.
Zdanys, K. F., Kleiman, T. G., Zhang, H., Ozbay, F., MacAvoy, M. G., Gelernter, J., & van Dyck, C. H. (2009). BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study. Journal of Alzheimer's Disease : JAD, 17(4), pp. 887-98. doi:10.3233/JAD-2009-1106.
Zdanys KF, et al. BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: an Exploratory Study. J Alzheimers Dis. 2009;17(4):887-98. PubMed PMID: 19542613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study. AU - Zdanys,Kristina F, AU - Kleiman,Timothy G, AU - Zhang,Huiping, AU - Ozbay,Fatih, AU - MacAvoy,Martha G, AU - Gelernter,Joel, AU - van Dyck,Christopher H, PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2010/9/24/medline SP - 887 EP - 98 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 17 IS - 4 N2 - Brain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal survival, growth, and differentiation. The role of BDNF in learning and memory suggests that it may also modulate the clinical course of Alzheimer's disease (AD). This study aimed to determine whether BDNF genetic variants are related to premorbid educational attainment, progression of cognitive and functional decline, and associated neuropsychiatric symptoms in AD patients. A sample of AD subjects (N = 341) was genotyped for the BDNF polymorphisms: Val66Met, C270T, and G-712A. Subjects received tests of cognition and daily function at baseline and at multiple subsequent time points. They were also characterized for the frequency and severity of neuropsychiatric symptoms. There was a significant effect of Val66Met genotype on educational attainment (F = 7.49, df = 2,329, P = 0.00066), with Met/Met homozygotes having significantly lower education than both the Val/Met and Val/Val groups. No association was observed between any BDNF polymorphism and measures of cognitive or functional decline. The T-allele of the C270T polymorphism was associated with a higher prevalence of neuropsychiatric symptoms and specifically with the presence of hallucinations. The effect of the Val66Met polymorphism on premorbid educational attainment is intriguing and should be verified in a larger sample. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/19542613/BDNF_variants_premorbid_educational_attainment_and_disease_characteristics_in_Alzheimer's_disease:_an_exploratory_study_ L2 - https://content.iospress.com/openurl?genre=article&issn=1387-2877&volume=17&issue=4&spage=887 DB - PRIME DP - Unbound Medicine ER -