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Physical activity and risk of endometrial cancer: an Italian case-control study.

Abstract

Most epidemiological studies on the relationship between physical activity and endometrial cancer found risk reductions of about 25-30% among most active women, but results were not consistent among studies. A multicentric case-control study was conducted in Italy between 1992 and 2006. Cases were 454 women with incident, histologically confirmed endometrial cancer and controls were 908 women admitted to hospital for acute non-neoplastic, nonhormonal conditions. Multivariate odds ratios (ORs) and the corresponding 95% confidence intervals were obtained after allowance for major potential confounding factors. The ORs of endometrial cancer for women in the highest level of occupational physical activity (compared with the lowest) were 1.69, 1.33, 1.17 and 0.82, respectively, at ages 12, 15-19, 30-39 and 50-59 years, with no trend in risk at any age. The corresponding ORs for leisure-time physical activity were 0.82, 0.78, 1.12 and 0.97. The risk of endometrial cancer for each level of occupational physical activity at age 30-39 years was not significantly heterogeneous across strata of age at diagnosis, body mass index, menopausal status and education. These findings do not support a strong relationship between physical activity and endometrial cancer risk.

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  • Authors+Show Affiliations

    ,

    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

    , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Case-Control Studies
    Child
    Endometrial Neoplasms
    Female
    Humans
    Italy
    Middle Aged
    Motor Activity
    Risk Factors
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19542982

    Citation

    Tavani, Alessandra, et al. "Physical Activity and Risk of Endometrial Cancer: an Italian Case-control Study." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 18, no. 4, 2009, pp. 303-6.
    Tavani A, Bravi F, Dal Maso L, et al. Physical activity and risk of endometrial cancer: an Italian case-control study. Eur J Cancer Prev. 2009;18(4):303-6.
    Tavani, A., Bravi, F., Dal Maso, L., Zucchetto, A., Bosetti, C., Pelucchi, C., ... La Vecchia, C. (2009). Physical activity and risk of endometrial cancer: an Italian case-control study. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 18(4), pp. 303-6. doi:10.1097/CEJ.0b013e32831bc3c4.
    Tavani A, et al. Physical Activity and Risk of Endometrial Cancer: an Italian Case-control Study. Eur J Cancer Prev. 2009;18(4):303-6. PubMed PMID: 19542982.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity and risk of endometrial cancer: an Italian case-control study. AU - Tavani,Alessandra, AU - Bravi,Francesca, AU - Dal Maso,Luigino, AU - Zucchetto,Antonella, AU - Bosetti,Cristina, AU - Pelucchi,Claudio, AU - Montella,Maurizio, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2010/3/6/medline SP - 303 EP - 6 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 18 IS - 4 N2 - Most epidemiological studies on the relationship between physical activity and endometrial cancer found risk reductions of about 25-30% among most active women, but results were not consistent among studies. A multicentric case-control study was conducted in Italy between 1992 and 2006. Cases were 454 women with incident, histologically confirmed endometrial cancer and controls were 908 women admitted to hospital for acute non-neoplastic, nonhormonal conditions. Multivariate odds ratios (ORs) and the corresponding 95% confidence intervals were obtained after allowance for major potential confounding factors. The ORs of endometrial cancer for women in the highest level of occupational physical activity (compared with the lowest) were 1.69, 1.33, 1.17 and 0.82, respectively, at ages 12, 15-19, 30-39 and 50-59 years, with no trend in risk at any age. The corresponding ORs for leisure-time physical activity were 0.82, 0.78, 1.12 and 0.97. The risk of endometrial cancer for each level of occupational physical activity at age 30-39 years was not significantly heterogeneous across strata of age at diagnosis, body mass index, menopausal status and education. These findings do not support a strong relationship between physical activity and endometrial cancer risk. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/19542982/Physical_activity_and_risk_of_endometrial_cancer:_an_Italian_case_control_study_ L2 - http://Insights.ovid.com/pubmed?pmid=19542982 DB - PRIME DP - Unbound Medicine ER -