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Donor risk index and MELD interactions in predicting long-term graft survival: a single-centre experience.
Transplantation. 2009 Jun 27; 87(12):1858-63.T

Abstract

INTRODUCTION

Feng et al. described the donor risk index (DRI) in North American liver transplant recipients. We evaluated the effect of the DRI and model for end-stage liver disease (MELD) score on liver transplant recipients from a single center in the United Kingdom.

METHOD

Prospectively, collected data of all patients transplanted at our center between January 1995 and December 2005 were included in the analysis (n=1090). Outcomes evaluated included patient-censored and death-censored graft survival. Outcomes of liver transplantation from "high" and "low" DRI groups (> or =1.8 and <1.8, respectively) on patients categorized into low (<15), intermediate (15-30), and high (>30) MELD categories were analyzed.

RESULTS

MELD at transplant was the only significant predictor of patient survival. MELD at transplant and DRI more than 1.7 were associated with a poorer graft survival (P=0.03). There was a trend toward poorer graft survival in high DRI grafts transplanted in low and "intermediate" MELD categories (P=0.47 and 0.006, respectively). However, in the high MELD category, there was a similar graft survival for both high and low DRI grafts.

CONCLUSION

Patients with low and intermediate MELDs at transplantation may be better served by a low DRI graft, whereas patients with high MELD may not be compromised by receiving a high DRI graft.

Authors+Show Affiliations

Department of Hepatobiliary and Transplantation Surgery, St James' Unviersity Hospital, Leeds, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19543065

Citation

Bonney, Glenn K., et al. "Donor Risk Index and MELD Interactions in Predicting Long-term Graft Survival: a Single-centre Experience." Transplantation, vol. 87, no. 12, 2009, pp. 1858-63.
Bonney GK, Aldersley MA, Asthana S, et al. Donor risk index and MELD interactions in predicting long-term graft survival: a single-centre experience. Transplantation. 2009;87(12):1858-63.
Bonney, G. K., Aldersley, M. A., Asthana, S., Toogood, G. J., Pollard, S. G., Lodge, J. P., & Prasad, K. R. (2009). Donor risk index and MELD interactions in predicting long-term graft survival: a single-centre experience. Transplantation, 87(12), 1858-63. https://doi.org/10.1097/TP.0b013e3181a75b37
Bonney GK, et al. Donor Risk Index and MELD Interactions in Predicting Long-term Graft Survival: a Single-centre Experience. Transplantation. 2009 Jun 27;87(12):1858-63. PubMed PMID: 19543065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Donor risk index and MELD interactions in predicting long-term graft survival: a single-centre experience. AU - Bonney,Glenn K, AU - Aldersley,Mark A, AU - Asthana,Sonal, AU - Toogood,Giles J, AU - Pollard,Stephen G, AU - Lodge,J Peter A, AU - Prasad,K Rajendra, PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2009/7/10/medline SP - 1858 EP - 63 JF - Transplantation JO - Transplantation VL - 87 IS - 12 N2 - INTRODUCTION: Feng et al. described the donor risk index (DRI) in North American liver transplant recipients. We evaluated the effect of the DRI and model for end-stage liver disease (MELD) score on liver transplant recipients from a single center in the United Kingdom. METHOD: Prospectively, collected data of all patients transplanted at our center between January 1995 and December 2005 were included in the analysis (n=1090). Outcomes evaluated included patient-censored and death-censored graft survival. Outcomes of liver transplantation from "high" and "low" DRI groups (> or =1.8 and <1.8, respectively) on patients categorized into low (<15), intermediate (15-30), and high (>30) MELD categories were analyzed. RESULTS: MELD at transplant was the only significant predictor of patient survival. MELD at transplant and DRI more than 1.7 were associated with a poorer graft survival (P=0.03). There was a trend toward poorer graft survival in high DRI grafts transplanted in low and "intermediate" MELD categories (P=0.47 and 0.006, respectively). However, in the high MELD category, there was a similar graft survival for both high and low DRI grafts. CONCLUSION: Patients with low and intermediate MELDs at transplantation may be better served by a low DRI graft, whereas patients with high MELD may not be compromised by receiving a high DRI graft. SN - 1534-6080 UR - https://www.unboundmedicine.com/medline/citation/19543065/Donor_risk_index_and_MELD_interactions_in_predicting_long_term_graft_survival:_a_single_centre_experience_ L2 - https://doi.org/10.1097/TP.0b013e3181a75b37 DB - PRIME DP - Unbound Medicine ER -