Tags

Type your tag names separated by a space and hit enter

The associations of LPIN1 gene expression in adipose tissue with metabolic phenotypes in the Chinese population.
Obesity (Silver Spring) 2010; 18(1):7-12O

Abstract

The LPIN1 gene, encoding lipin-1 protein, plays critical roles in adipocyte differentiation and lipid metabolism. This study aimed to analyze the association of LPIN1 mRNA levels in human adipose tissue with metabolic phenotypes. We also examined the association of LPIN1 genetic variation with type 2 diabetes and related metabolic phenotypes in the Chinese population. The relative LPIN1 mRNA levels were measured in abdominal visceral (VAT) and subcutaneous adipose tissue (SAT) obtained from 102 nondiabetic Chinese females. Seven single-nucleotide polymorphisms (SNPs) spanning from the 5'-upstream region to the 3'-end of the LPIN1 gene were genotyped in 1,520 Chinese (760 type 2 diabetic cases and 760 controls). LPIN1 mRNA levels in VAT were negatively correlated with BMI (r = -0.21, P = 0.03), body fat percentage (r = -0.22, P = 0.02), plasma triglycerides levels (r = -0.21, P = 0.03), and plasma leptin levels (r = -0.63, P = 0.0002). LPIN1 mRNA levels were positively correlated with PPARG and ADIPOQ mRNA levels in both VAT and SAT. No single SNP of the LPIN1 gene was associated with type 2 diabetes in our population. One rare haplotype showed a significant association with type 2 diabetes (odds ratio (OR), 4.35; 95% confidence interval, 1.86-11.75; P = 4 x 10(-4)). No SNP or haplotype of the LPIN1 gene was associated with quantitative metabolic traits in the nondiabetic subjects. The results confirmed the association of LPIN1 gene expression in adipose tissue with lower adiposity and favorable metabolic profiles in the Chinese population. However, the LPIN1 gene seemed not to be a major susceptibility gene for type 2 diabetes or related metabolic phenotypes in the Chinese population.

Authors+Show Affiliations

Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19543209

Citation

Chang, Yi-Cheng, et al. "The Associations of LPIN1 Gene Expression in Adipose Tissue With Metabolic Phenotypes in the Chinese Population." Obesity (Silver Spring, Md.), vol. 18, no. 1, 2010, pp. 7-12.
Chang YC, Chang LY, Chang TJ, et al. The associations of LPIN1 gene expression in adipose tissue with metabolic phenotypes in the Chinese population. Obesity (Silver Spring). 2010;18(1):7-12.
Chang, Y. C., Chang, L. Y., Chang, T. J., Jiang, Y. D., Lee, K. C., Kuo, S. S., ... Chuang, L. M. (2010). The associations of LPIN1 gene expression in adipose tissue with metabolic phenotypes in the Chinese population. Obesity (Silver Spring, Md.), 18(1), pp. 7-12. doi:10.1038/oby.2009.198.
Chang YC, et al. The Associations of LPIN1 Gene Expression in Adipose Tissue With Metabolic Phenotypes in the Chinese Population. Obesity (Silver Spring). 2010;18(1):7-12. PubMed PMID: 19543209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The associations of LPIN1 gene expression in adipose tissue with metabolic phenotypes in the Chinese population. AU - Chang,Yi-Cheng, AU - Chang,Ling-Yin, AU - Chang,Tien-Jyun, AU - Jiang,Yi-Der, AU - Lee,Kuan-Ching, AU - Kuo,Shan-Shan, AU - Lee,Wei-Jei, AU - Chuang,Lee-Ming, Y1 - 2009/06/18/ PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2010/4/1/medline SP - 7 EP - 12 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 18 IS - 1 N2 - The LPIN1 gene, encoding lipin-1 protein, plays critical roles in adipocyte differentiation and lipid metabolism. This study aimed to analyze the association of LPIN1 mRNA levels in human adipose tissue with metabolic phenotypes. We also examined the association of LPIN1 genetic variation with type 2 diabetes and related metabolic phenotypes in the Chinese population. The relative LPIN1 mRNA levels were measured in abdominal visceral (VAT) and subcutaneous adipose tissue (SAT) obtained from 102 nondiabetic Chinese females. Seven single-nucleotide polymorphisms (SNPs) spanning from the 5'-upstream region to the 3'-end of the LPIN1 gene were genotyped in 1,520 Chinese (760 type 2 diabetic cases and 760 controls). LPIN1 mRNA levels in VAT were negatively correlated with BMI (r = -0.21, P = 0.03), body fat percentage (r = -0.22, P = 0.02), plasma triglycerides levels (r = -0.21, P = 0.03), and plasma leptin levels (r = -0.63, P = 0.0002). LPIN1 mRNA levels were positively correlated with PPARG and ADIPOQ mRNA levels in both VAT and SAT. No single SNP of the LPIN1 gene was associated with type 2 diabetes in our population. One rare haplotype showed a significant association with type 2 diabetes (odds ratio (OR), 4.35; 95% confidence interval, 1.86-11.75; P = 4 x 10(-4)). No SNP or haplotype of the LPIN1 gene was associated with quantitative metabolic traits in the nondiabetic subjects. The results confirmed the association of LPIN1 gene expression in adipose tissue with lower adiposity and favorable metabolic profiles in the Chinese population. However, the LPIN1 gene seemed not to be a major susceptibility gene for type 2 diabetes or related metabolic phenotypes in the Chinese population. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/19543209/The_associations_of_LPIN1_gene_expression_in_adipose_tissue_with_metabolic_phenotypes_in_the_Chinese_population_ L2 - https://doi.org/10.1038/oby.2009.198 DB - PRIME DP - Unbound Medicine ER -