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Leptin concentrations in the peritoneal fluid of women with ovarian endometriosis are different according to the presence of a 'deep' or 'superficial' ovarian disease.
Gynecol Endocrinol 2009; 25(9):610-5GE

Abstract

Some studies have suggested a possible role of leptin, an active cytokine produced by adipocytes, in the pathogenesis of pelvic endometriosis. The present study was designed to assess leptin levels in the peritoneal fluid (PF) of women with the 'deep' or 'superficial' types of ovarian endometriosis. Twenty-seven women with a single ovarian endometrioma having a mean diameter between 3 and 5 cm were included in the study. Patients were divided into two groups according to the type of ovarian endometriosis: Group A (n = 11) consisted of women with 'superficial' endometriomas located at the ovarian surface; Group B (n = 16) included patients with 'deep' intra-ovarian endometriomas. Women undergoing laparoscopy for unexplained infertility and not affected by pelvic and/or ovarian endometriosis were considered as controls (Group C, n = 10). Patients with an ovarian endometrioma had significantly increased PF leptin concentrations than endometriosis-free controls (Groups A and B vs. Group C, p < 0.01). Patients with 'superficial' endometriomas had significantly higher PF leptin levels compared with patients with 'deep' endometriomas (Group A vs. B, p < 0.01). This difference remained significant after correction for the BMI; moreover, a positive correlation between PF leptin and BMI was observed in Groups B and C, but not in women with 'superficial' endometrioma (Group A). Our observations suggest that: (a) leptin could play an active role in promoting the development of 'superficial' ovarian endometriomas and (b) 'superficial' and 'deep' ovarian endometriomas could have a different pathogenesis.

Authors+Show Affiliations

Department of Obstetrical, Gynecological and Urological Sciences, Turin, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19544117

Citation

Alviggi, Carlo, et al. "Leptin Concentrations in the Peritoneal Fluid of Women With Ovarian Endometriosis Are Different According to the Presence of a 'deep' or 'superficial' Ovarian Disease." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 25, no. 9, 2009, pp. 610-5.
Alviggi C, Clarizia R, Castaldo G, et al. Leptin concentrations in the peritoneal fluid of women with ovarian endometriosis are different according to the presence of a 'deep' or 'superficial' ovarian disease. Gynecol Endocrinol. 2009;25(9):610-5.
Alviggi, C., Clarizia, R., Castaldo, G., Matarese, G., Colucci, C. C., Conforti, S., ... De Placido, G. (2009). Leptin concentrations in the peritoneal fluid of women with ovarian endometriosis are different according to the presence of a 'deep' or 'superficial' ovarian disease. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 25(9), pp. 610-5. doi:10.1080/09513590903015577.
Alviggi C, et al. Leptin Concentrations in the Peritoneal Fluid of Women With Ovarian Endometriosis Are Different According to the Presence of a 'deep' or 'superficial' Ovarian Disease. Gynecol Endocrinol. 2009;25(9):610-5. PubMed PMID: 19544117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin concentrations in the peritoneal fluid of women with ovarian endometriosis are different according to the presence of a 'deep' or 'superficial' ovarian disease. AU - Alviggi,Carlo, AU - Clarizia,Roberto, AU - Castaldo,Gennaro, AU - Matarese,Giuseppe, AU - Colucci,Camillo C, AU - Conforti,Salvatore, AU - Pagano,Tiziana, AU - Revelli,Alberto, AU - De Placido,Giuseppe, PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2010/1/27/medline SP - 610 EP - 5 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 25 IS - 9 N2 - Some studies have suggested a possible role of leptin, an active cytokine produced by adipocytes, in the pathogenesis of pelvic endometriosis. The present study was designed to assess leptin levels in the peritoneal fluid (PF) of women with the 'deep' or 'superficial' types of ovarian endometriosis. Twenty-seven women with a single ovarian endometrioma having a mean diameter between 3 and 5 cm were included in the study. Patients were divided into two groups according to the type of ovarian endometriosis: Group A (n = 11) consisted of women with 'superficial' endometriomas located at the ovarian surface; Group B (n = 16) included patients with 'deep' intra-ovarian endometriomas. Women undergoing laparoscopy for unexplained infertility and not affected by pelvic and/or ovarian endometriosis were considered as controls (Group C, n = 10). Patients with an ovarian endometrioma had significantly increased PF leptin concentrations than endometriosis-free controls (Groups A and B vs. Group C, p < 0.01). Patients with 'superficial' endometriomas had significantly higher PF leptin levels compared with patients with 'deep' endometriomas (Group A vs. B, p < 0.01). This difference remained significant after correction for the BMI; moreover, a positive correlation between PF leptin and BMI was observed in Groups B and C, but not in women with 'superficial' endometrioma (Group A). Our observations suggest that: (a) leptin could play an active role in promoting the development of 'superficial' ovarian endometriomas and (b) 'superficial' and 'deep' ovarian endometriomas could have a different pathogenesis. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/19544117/Leptin_concentrations_in_the_peritoneal_fluid_of_women_with_ovarian_endometriosis_are_different_according_to_the_presence_of_a_'deep'_or_'superficial'_ovarian_disease_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590903015577 DB - PRIME DP - Unbound Medicine ER -