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Measurement of common carotid artery intima-media thickness in clinical practice: comparison of B-mode and RF-based technique.

Abstract

PURPOSE

The common carotid artery intima-media thickness (CCA-IMT) is usually measured using B-mode ultrasound images. A different approach for CCA-IMT detection is based on radio frequency (RF) multiple M-line analysis.

MATERIALS AND METHODS

The present study explores the relationship between B-mode and RF measurement of CCA-IMT, as well as the reproducibility of both methods in 136 patients recently diagnosed with cardiovascular disease. Within one session, repeated measurements were made in the distal CCA bilaterally, using the B-mode (averaged over 10 mm) and RF technique (averaging 12 M-lines over 14 mm).

RESULTS

The two methods correlate well (Pearson r = 0.765). The CCA-IMT values measured with B-mode and RF were 0.779 +/- 0.196 mm and 0.734 +/- 0.172 mm, respectively. B-mode CCA-IMT is significantly larger than RF CCA-IMT (mean difference of 0.045 mm, SEM 7.8 microm; t = 5.82; p < 0.001). In the multivariate regression analysis, carotid artery stenosis, inhomogeneous IMT and diabetes mellitus were the main predictors of differences between B-mode and RF CCA-IMT. The intrapatient variation for B-mode and RF-based CCA-IMT is comparable (0.05 +/- 0.04 mm and 0.07 +/- 0.05 mm, respectively).

CONCLUSION

CCA-IMT values measured with RF and B-mode have similar reproducibility and exhibit acceptable correlation, but RF CCA-IMT is significantly smaller. The difference between both methods is mainly due to advanced atherosclerosis. Hence, both methods can be used reliably to measure CCA-IMT in clinical practice.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Neurophysiology, Maastricht University Medical Centre, 6202 AZ Maastricht, Netherlands. fschreuder@gmail.com

    , , ,

    Source

    MeSH

    Aged
    Artifacts
    Atherosclerosis
    Automation
    Cardiovascular Diseases
    Carotid Artery Diseases
    Carotid Artery, Common
    Female
    Humans
    Male
    Middle Aged
    Radio Waves
    Reference Values
    Reproducibility of Results
    Risk Factors
    Software
    Tunica Intima
    Tunica Media
    Ultrasonography

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19544231

    Citation

    Schreuder, F H., et al. "Measurement of Common Carotid Artery Intima-media Thickness in Clinical Practice: Comparison of B-mode and RF-based Technique." Ultraschall in Der Medizin (Stuttgart, Germany : 1980), vol. 30, no. 5, 2009, pp. 459-65.
    Schreuder FH, Graf M, Hameleers JM, et al. Measurement of common carotid artery intima-media thickness in clinical practice: comparison of B-mode and RF-based technique. Ultraschall Med. 2009;30(5):459-65.
    Schreuder, F. H., Graf, M., Hameleers, J. M., Mess, W. H., & Hoeks, A. P. (2009). Measurement of common carotid artery intima-media thickness in clinical practice: comparison of B-mode and RF-based technique. Ultraschall in Der Medizin (Stuttgart, Germany : 1980), 30(5), pp. 459-65. doi:10.1055/s-0028-1109187.
    Schreuder FH, et al. Measurement of Common Carotid Artery Intima-media Thickness in Clinical Practice: Comparison of B-mode and RF-based Technique. Ultraschall Med. 2009;30(5):459-65. PubMed PMID: 19544231.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Measurement of common carotid artery intima-media thickness in clinical practice: comparison of B-mode and RF-based technique. AU - Schreuder,F H, AU - Graf,M, AU - Hameleers,J M, AU - Mess,W H, AU - Hoeks,A P, Y1 - 2009/06/18/ PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2010/1/14/medline SP - 459 EP - 65 JF - Ultraschall in der Medizin (Stuttgart, Germany : 1980) JO - Ultraschall Med VL - 30 IS - 5 N2 - PURPOSE: The common carotid artery intima-media thickness (CCA-IMT) is usually measured using B-mode ultrasound images. A different approach for CCA-IMT detection is based on radio frequency (RF) multiple M-line analysis. MATERIALS AND METHODS: The present study explores the relationship between B-mode and RF measurement of CCA-IMT, as well as the reproducibility of both methods in 136 patients recently diagnosed with cardiovascular disease. Within one session, repeated measurements were made in the distal CCA bilaterally, using the B-mode (averaged over 10 mm) and RF technique (averaging 12 M-lines over 14 mm). RESULTS: The two methods correlate well (Pearson r = 0.765). The CCA-IMT values measured with B-mode and RF were 0.779 +/- 0.196 mm and 0.734 +/- 0.172 mm, respectively. B-mode CCA-IMT is significantly larger than RF CCA-IMT (mean difference of 0.045 mm, SEM 7.8 microm; t = 5.82; p < 0.001). In the multivariate regression analysis, carotid artery stenosis, inhomogeneous IMT and diabetes mellitus were the main predictors of differences between B-mode and RF CCA-IMT. The intrapatient variation for B-mode and RF-based CCA-IMT is comparable (0.05 +/- 0.04 mm and 0.07 +/- 0.05 mm, respectively). CONCLUSION: CCA-IMT values measured with RF and B-mode have similar reproducibility and exhibit acceptable correlation, but RF CCA-IMT is significantly smaller. The difference between both methods is mainly due to advanced atherosclerosis. Hence, both methods can be used reliably to measure CCA-IMT in clinical practice. SN - 1438-8782 UR - https://www.unboundmedicine.com/medline/citation/19544231/Measurement_of_common_carotid_artery_intima_media_thickness_in_clinical_practice:_comparison_of_B_mode_and_RF_based_technique_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0028-1109187 DB - PRIME DP - Unbound Medicine ER -