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Growth patterns in children with sickle cell anemia during puberty.
Pediatr Blood Cancer. 2009 Oct; 53(4):635-41.PB

Abstract

BACKGROUND

Previous studies of children with homozygous sickle cell anemia (SCA) show impaired growth and maturation. The correlation of this suboptimal growth with metabolic and hematological factors during puberty is poorly understood.

PROCEDURE

We studied a group of pre-adolescent children with SCA (19 males, 14 females) and healthy controls (16 males, 15 females) matched for race, sex, body size, and pubertal development. Height, weight, body mass index (BMI), and body composition changes were longitudinally assessed over a 2-year period and compared between the groups and with Z scores based on US growth charts. These changes were correlated with hemoglobin (Hgb) concentration and with energy expenditure (EE) measured using indirect whole-room calorimetry.

RESULTS

Children with SCA progressed through puberty slower than control children. While, after 2 years, pubertal males with SCA were shorter, their annual increases in weight were not different from controls. The mean fat free mass (FFM) increments were significantly less in males and females with SCA than in control children. In males with SCA, growth in height declined over time and was significantly slower than in matched controls (P < 0.05).

CONCLUSION

Growth delays were present during puberty in children with SCA. Decreased growth velocity in children with SCA was independently associated with decreased Hgb concentration and increased total EE.

Authors+Show Affiliations

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19544390

Citation

Rhodes, Melissa, et al. "Growth Patterns in Children With Sickle Cell Anemia During Puberty." Pediatric Blood & Cancer, vol. 53, no. 4, 2009, pp. 635-41.
Rhodes M, Akohoue SA, Shankar SM, et al. Growth patterns in children with sickle cell anemia during puberty. Pediatr Blood Cancer. 2009;53(4):635-41.
Rhodes, M., Akohoue, S. A., Shankar, S. M., Fleming, I., Qi An, A., Yu, C., Acra, S., & Buchowski, M. S. (2009). Growth patterns in children with sickle cell anemia during puberty. Pediatric Blood & Cancer, 53(4), 635-41. https://doi.org/10.1002/pbc.22137
Rhodes M, et al. Growth Patterns in Children With Sickle Cell Anemia During Puberty. Pediatr Blood Cancer. 2009;53(4):635-41. PubMed PMID: 19544390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth patterns in children with sickle cell anemia during puberty. AU - Rhodes,Melissa, AU - Akohoue,Sylvie A, AU - Shankar,Sadhna M, AU - Fleming,Irma, AU - Qi An,Angel, AU - Yu,Chung, AU - Acra,Sari, AU - Buchowski,Maciej S, PY - 2009/6/23/entrez PY - 2009/6/23/pubmed PY - 2009/9/9/medline SP - 635 EP - 41 JF - Pediatric blood & cancer JO - Pediatr Blood Cancer VL - 53 IS - 4 N2 - BACKGROUND: Previous studies of children with homozygous sickle cell anemia (SCA) show impaired growth and maturation. The correlation of this suboptimal growth with metabolic and hematological factors during puberty is poorly understood. PROCEDURE: We studied a group of pre-adolescent children with SCA (19 males, 14 females) and healthy controls (16 males, 15 females) matched for race, sex, body size, and pubertal development. Height, weight, body mass index (BMI), and body composition changes were longitudinally assessed over a 2-year period and compared between the groups and with Z scores based on US growth charts. These changes were correlated with hemoglobin (Hgb) concentration and with energy expenditure (EE) measured using indirect whole-room calorimetry. RESULTS: Children with SCA progressed through puberty slower than control children. While, after 2 years, pubertal males with SCA were shorter, their annual increases in weight were not different from controls. The mean fat free mass (FFM) increments were significantly less in males and females with SCA than in control children. In males with SCA, growth in height declined over time and was significantly slower than in matched controls (P < 0.05). CONCLUSION: Growth delays were present during puberty in children with SCA. Decreased growth velocity in children with SCA was independently associated with decreased Hgb concentration and increased total EE. SN - 1545-5017 UR - https://www.unboundmedicine.com/medline/citation/19544390/Growth_patterns_in_children_with_sickle_cell_anemia_during_puberty_ L2 - https://doi.org/10.1002/pbc.22137 DB - PRIME DP - Unbound Medicine ER -