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A pilot study of the effect of diclofenac with B vitamins for the treatment of acute pain following lower-limb fracture and surgery.
Proc West Pharmacol Soc. 2008; 51:70-2.PW

Abstract

The aim of this pilot study was to compare the efficacy and tolerability of the non-steroidal anti-inflammatory drug (NSAID), diclofenac (2-(2,6-dichloranilino) phenylacetic acid), for treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins. This clinical trial was single-center, prospective randomized and double-blinded. After giving informed consent, patients with lower-limb closed fractures rated their pain on a 10-cm visual analog scale (VAS). Patients were then randomized to receive 75 mg diclofenac or 75 mg diclofenac plus B vitamins (thiamine, pyridoxine and cyanocobalamin) twice daily (all intramuscularly). Patient evaluations of pain intensity were recorded throughout two periods: twenty-four hours pre-surgically and twenty-four hours postsurgical. Twenty-four hours after the first drug administration, patients underwent elective lower-limb surgery. Standardized general anesthetic techniques were used for all patients. Fourteen patients completed the study. The subjects' assessments of limb pain on the visual analog scale showed a significant reduction from baseline values regardless of the treatment group when surveyed at 12, 24, 36 and 48 hr post operation. All treatments showed a similar profile in pain reduction. There were reports of pain in the administration site, but in general, all the regimens were well tolerated.

Authors+Show Affiliations

Hospital General de los Servicios de Salud del Estado de Hidalgo, Pachuca, Hidalgo, México.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19544682

Citation

Garza, Alexis F., et al. "A Pilot Study of the Effect of Diclofenac With B Vitamins for the Treatment of Acute Pain Following Lower-limb Fracture and Surgery." Proceedings of the Western Pharmacology Society, vol. 51, 2008, pp. 70-2.
Garza AF, Monroy-Maya R, Soto-Ríos M, et al. A pilot study of the effect of diclofenac with B vitamins for the treatment of acute pain following lower-limb fracture and surgery. Proc West Pharmacol Soc. 2008;51:70-2.
Garza, A. F., Monroy-Maya, R., Soto-Ríos, M., Reyes-García, G., Carrillo-Alarcón, L., Ponce-Monter, H., Rangel-Flores, E., & Ortiz, M. I. (2008). A pilot study of the effect of diclofenac with B vitamins for the treatment of acute pain following lower-limb fracture and surgery. Proceedings of the Western Pharmacology Society, 51, 70-2.
Garza AF, et al. A Pilot Study of the Effect of Diclofenac With B Vitamins for the Treatment of Acute Pain Following Lower-limb Fracture and Surgery. Proc West Pharmacol Soc. 2008;51:70-2. PubMed PMID: 19544682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pilot study of the effect of diclofenac with B vitamins for the treatment of acute pain following lower-limb fracture and surgery. AU - Garza,Alexis F, AU - Monroy-Maya,Raúl, AU - Soto-Ríos,Marisela, AU - Reyes-García,Gerardo, AU - Carrillo-Alarcón,Lourdes, AU - Ponce-Monter,Héctor, AU - Rangel-Flores,Eduardo, AU - Ortiz,Mario I, PY - 2009/6/24/entrez PY - 2008/1/1/pubmed PY - 2009/8/11/medline SP - 70 EP - 2 JF - Proceedings of the Western Pharmacology Society JO - Proc West Pharmacol Soc VL - 51 N2 - The aim of this pilot study was to compare the efficacy and tolerability of the non-steroidal anti-inflammatory drug (NSAID), diclofenac (2-(2,6-dichloranilino) phenylacetic acid), for treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins. This clinical trial was single-center, prospective randomized and double-blinded. After giving informed consent, patients with lower-limb closed fractures rated their pain on a 10-cm visual analog scale (VAS). Patients were then randomized to receive 75 mg diclofenac or 75 mg diclofenac plus B vitamins (thiamine, pyridoxine and cyanocobalamin) twice daily (all intramuscularly). Patient evaluations of pain intensity were recorded throughout two periods: twenty-four hours pre-surgically and twenty-four hours postsurgical. Twenty-four hours after the first drug administration, patients underwent elective lower-limb surgery. Standardized general anesthetic techniques were used for all patients. Fourteen patients completed the study. The subjects' assessments of limb pain on the visual analog scale showed a significant reduction from baseline values regardless of the treatment group when surveyed at 12, 24, 36 and 48 hr post operation. All treatments showed a similar profile in pain reduction. There were reports of pain in the administration site, but in general, all the regimens were well tolerated. SN - 0083-8969 UR - https://www.unboundmedicine.com/medline/citation/19544682/A_pilot_study_of_the_effect_of_diclofenac_with_B_vitamins_for_the_treatment_of_acute_pain_following_lower_limb_fracture_and_surgery_ L2 - https://medlineplus.gov/bvitamins.html DB - PRIME DP - Unbound Medicine ER -