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[Study of ALAD and VDR gene polymorphisms associated with lead nephrotoxicity susceptibility].
Wei Sheng Yan Jiu. 2009 May; 38(3):326-9.WS

Abstract

OBJECTIVE

To explore lead nephrotoxicity associated with delta-aminolevulinic acid dehydratase, vitamin D receptor gene polymorphism as well as joint effect of gene-gene, gene-environment.

METHODS

233 occupational lead-exposed workers were involved in this study. Then blood lead was detected as lead exposure biomarker. Urinary N-acetyl-beta-D-glucosamindase and beta2-microglobin of those workers were measured as biomarkers of nephrotoxicity. PCR-RFLP method was used for gene polymorphism analysing.

RESULTS

Lead exposure concentration was higher than national limit, NAG acticity were (2.12 +/- 0.07) U/mmol Cr in workers with ALAD1-2/ALAD2-2 genotype and (1.73 +/- 0.03) U/mmol Cr in workers with ALAD1-1 genotype (P < 0.05). In the same condition, beta2-MG were (20.94 +/- 1.12) microg/mmol Cr in workers with VDR-Bb genotype and (15.28 +/- 0.09) microg/mmol Cr in workers with VDR-bb genotype (P = 0.01). Analysis of logistic regression confirmed that lead exposure and high blood lead as well as combined effect of gene-environment were responsible for lead nephrotoxicity in workers (OR = 6.58, 2.41, 3.01).

CONCLUSION

Polymorphisms of ALAD and VDR gene may play an important role in lead nephrotoxicity in high lead-exposed workers. Joint effect of gene-environment could be involved in lead nephrotoxicity in workers.

Authors+Show Affiliations

Wang A
Ningbo Municipal Center For Disease Control and Prevention, Ningbo 315010, China.
Wang Q
No affiliation info available
Song Q
No affiliation info available
Xu J
No affiliation info available

MeSH

AcetylglucosaminidaseAdultFemaleGenetic Predisposition to DiseaseHumansKidney DiseasesLeadLead PoisoningMaleMiddle AgedOccupational ExposurePolymorphism, GeneticPorphobilinogen SynthaseReceptors, CalcitriolYoung Adultbeta 2-Microglobulin

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19548578

Citation

Wang, Aihong, et al. "[Study of ALAD and VDR Gene Polymorphisms Associated With Lead Nephrotoxicity Susceptibility]." Wei Sheng Yan Jiu = Journal of Hygiene Research, vol. 38, no. 3, 2009, pp. 326-9.
Wang A, Wang Q, Song Q, et al. [Study of ALAD and VDR gene polymorphisms associated with lead nephrotoxicity susceptibility]. Wei Sheng Yan Jiu. 2009;38(3):326-9.
Wang, A., Wang, Q., Song, Q., & Xu, J. (2009). [Study of ALAD and VDR gene polymorphisms associated with lead nephrotoxicity susceptibility]. Wei Sheng Yan Jiu = Journal of Hygiene Research, 38(3), 326-9.
Wang A, et al. [Study of ALAD and VDR Gene Polymorphisms Associated With Lead Nephrotoxicity Susceptibility]. Wei Sheng Yan Jiu. 2009;38(3):326-9. PubMed PMID: 19548578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study of ALAD and VDR gene polymorphisms associated with lead nephrotoxicity susceptibility]. AU - Wang,Aihong, AU - Wang,Qunli, AU - Song,Qifa, AU - Xu,Jingye, PY - 2009/6/25/entrez PY - 2009/6/25/pubmed PY - 2012/8/24/medline SP - 326 EP - 9 JF - Wei sheng yan jiu = Journal of hygiene research JO - Wei Sheng Yan Jiu VL - 38 IS - 3 N2 - OBJECTIVE: To explore lead nephrotoxicity associated with delta-aminolevulinic acid dehydratase, vitamin D receptor gene polymorphism as well as joint effect of gene-gene, gene-environment. METHODS: 233 occupational lead-exposed workers were involved in this study. Then blood lead was detected as lead exposure biomarker. Urinary N-acetyl-beta-D-glucosamindase and beta2-microglobin of those workers were measured as biomarkers of nephrotoxicity. PCR-RFLP method was used for gene polymorphism analysing. RESULTS: Lead exposure concentration was higher than national limit, NAG acticity were (2.12 +/- 0.07) U/mmol Cr in workers with ALAD1-2/ALAD2-2 genotype and (1.73 +/- 0.03) U/mmol Cr in workers with ALAD1-1 genotype (P < 0.05). In the same condition, beta2-MG were (20.94 +/- 1.12) microg/mmol Cr in workers with VDR-Bb genotype and (15.28 +/- 0.09) microg/mmol Cr in workers with VDR-bb genotype (P = 0.01). Analysis of logistic regression confirmed that lead exposure and high blood lead as well as combined effect of gene-environment were responsible for lead nephrotoxicity in workers (OR = 6.58, 2.41, 3.01). CONCLUSION: Polymorphisms of ALAD and VDR gene may play an important role in lead nephrotoxicity in high lead-exposed workers. Joint effect of gene-environment could be involved in lead nephrotoxicity in workers. SN - 1000-8020 UR - https://www.unboundmedicine.com/medline/citation/19548578/[Study_of_ALAD_and_VDR_gene_polymorphisms_associated_with_lead_nephrotoxicity_susceptibility]_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -