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Effect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trial.
J Am Geriatr Soc. 2009 Aug; 57(8):1481-6.JA

Abstract

OBJECTIVES

To investigate the effect of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplementation on quality of life (QOL).

DESIGN

Randomized, double-blind, placebo-controlled trial.

SETTING

Independently living individuals from the general older Dutch population.

PARTICIPANTS

Three hundred two individuals aged 65 and older without depression or dementia.

INTERVENTION

1,800 mg/d EPA-DHA (n=96), 400 mg/d EPA-DHA (n=100), or placebo capsules (n=106) for 26 weeks.

MEASUREMENTS

QOL was assessed using the short version of the World Health Organization QOL questionnaire (WHOQOL-BREF). The WHOQOL-BREF covers four domains: physical health, psychological health, social relationships, and satisfaction with environment. The total score range is 26 to 130, with higher scores indicating a more favorable condition.

RESULTS

Mean age of the participants was 70, and 55% were male. Plasma concentrations of EPA-DHA increased 238% in the high-dose and 51% in the low-dose EPA-DHA group, reflecting excellent adherence. Median baseline total WHOQOL scores ranged from 107 to 110 in the three groups and were not significantly different from each other. After 26 weeks, the mean difference from placebo was -1.42 (95% confidence interval (CI)=-3.40-0.57) for the high-dose and 0.02 (95% CI=-1.95-1.99) for the low-dose fish oil group. Treatment with 1,800 mg or 400 mg EPA-DHA did not affect total QOL or any of the separate domains after 13 or 26 weeks of intervention.

CONCLUSION

Supplementation with high or low doses of fish oil for 26 weeks did not influence the QOL of healthy older individuals.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. Ondine.vandeRest@wur.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19549020

Citation

van de Rest, Ondine, et al. "Effect of Fish Oil Supplementation On Quality of Life in a General Population of Older Dutch Subjects: a Randomized, Double-blind, Placebo-controlled Trial." Journal of the American Geriatrics Society, vol. 57, no. 8, 2009, pp. 1481-6.
van de Rest O, Geleijnse JM, Kok FJ, et al. Effect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trial. J Am Geriatr Soc. 2009;57(8):1481-6.
van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Olderikkert, M. G., Beekman, A. T., & de Groot, L. C. (2009). Effect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trial. Journal of the American Geriatrics Society, 57(8), 1481-6. https://doi.org/10.1111/j.1532-5415.2009.02361.x
van de Rest O, et al. Effect of Fish Oil Supplementation On Quality of Life in a General Population of Older Dutch Subjects: a Randomized, Double-blind, Placebo-controlled Trial. J Am Geriatr Soc. 2009;57(8):1481-6. PubMed PMID: 19549020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trial. AU - van de Rest,Ondine, AU - Geleijnse,Johanna M, AU - Kok,Frans J, AU - van Staveren,Wija A, AU - Olderikkert,Marcel G M, AU - Beekman,Aartjan T F, AU - de Groot,Lisette C P G M, Y1 - 2009/06/22/ PY - 2009/6/25/entrez PY - 2009/6/25/pubmed PY - 2009/9/16/medline SP - 1481 EP - 6 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 57 IS - 8 N2 - OBJECTIVES: To investigate the effect of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplementation on quality of life (QOL). DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Independently living individuals from the general older Dutch population. PARTICIPANTS: Three hundred two individuals aged 65 and older without depression or dementia. INTERVENTION: 1,800 mg/d EPA-DHA (n=96), 400 mg/d EPA-DHA (n=100), or placebo capsules (n=106) for 26 weeks. MEASUREMENTS: QOL was assessed using the short version of the World Health Organization QOL questionnaire (WHOQOL-BREF). The WHOQOL-BREF covers four domains: physical health, psychological health, social relationships, and satisfaction with environment. The total score range is 26 to 130, with higher scores indicating a more favorable condition. RESULTS: Mean age of the participants was 70, and 55% were male. Plasma concentrations of EPA-DHA increased 238% in the high-dose and 51% in the low-dose EPA-DHA group, reflecting excellent adherence. Median baseline total WHOQOL scores ranged from 107 to 110 in the three groups and were not significantly different from each other. After 26 weeks, the mean difference from placebo was -1.42 (95% confidence interval (CI)=-3.40-0.57) for the high-dose and 0.02 (95% CI=-1.95-1.99) for the low-dose fish oil group. Treatment with 1,800 mg or 400 mg EPA-DHA did not affect total QOL or any of the separate domains after 13 or 26 weeks of intervention. CONCLUSION: Supplementation with high or low doses of fish oil for 26 weeks did not influence the QOL of healthy older individuals. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/19549020/Effect_of_fish_oil_supplementation_on_quality_of_life_in_a_general_population_of_older_Dutch_subjects:_a_randomized_double_blind_placebo_controlled_trial_ L2 - https://doi.org/10.1111/j.1532-5415.2009.02361.x DB - PRIME DP - Unbound Medicine ER -