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Interval from prostate biopsy to robot-assisted radical prostatectomy: effects on perioperative outcomes.
BJU Int. 2009 Dec; 104(11):1734-7.BI

Abstract

OBJECTIVE

To determine whether shorter intervals (<4 and 6 weeks) between prostate biopsy and robot-assisted radical prostatectomy (RARP) have a detrimental effect on perioperative outcomes, as recent studies showed that open RP shortly after prostate biopsy does not adversely influence surgical difficulty or efficacy, but RARP relies solely on visual cues rather than tactile sensation to determine posterior surgical planes of dissection.

PATIENTS AND METHODS

A series of 559 patients undergoing RARP from March 2004 to July 2007 was retrospectively reviewed. The interval between prostate biopsy and RARP was determined and patients with intervals of <or=4 weeks were compared to those >4 weeks. Patient characteristics and perioperative outcomes were analysed to determine statistically significant differences between the groups. This comparison was then repeated with a <or=6- vs >6-week interval, and examined with a multivariate logistic regression analysis.

RESULTS

In the <or=4-week group (27 patients) vs the >4-week group (509 patients), there was a significantly (P < 0.05) higher rate of complications (18.5% vs 6.9%). In the <or=6-week group (81 patients) vs the >6-week group (455 patients) there was a smaller but still significantly higher rate of complications (13.6% vs 6.4%). These results were still significant when controlling for patient and disease characteristics and the 'learning curve'. There was also a significantly higher rate of transfusion in the <or=6-week group (3.7%) than the >6-week group (0.7%).

CONCLUSIONS

Our data suggest that RARP should be delayed after prostate biopsy; RARP within 6 weeks of biopsy was associated with a greater risk of complications even when controlling for disease and patient characteristics.

Authors+Show Affiliations

Urology, Mayo Clinic Arizona, Phoenix, AZ, USA. martin.george@mayo.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19549123

Citation

Martin, George L., et al. "Interval From Prostate Biopsy to Robot-assisted Radical Prostatectomy: Effects On Perioperative Outcomes." BJU International, vol. 104, no. 11, 2009, pp. 1734-7.
Martin GL, Nunez RN, Humphreys MD, et al. Interval from prostate biopsy to robot-assisted radical prostatectomy: effects on perioperative outcomes. BJU Int. 2009;104(11):1734-7.
Martin, G. L., Nunez, R. N., Humphreys, M. D., Martin, A. D., Ferrigni, R. G., Andrews, P. E., & Castle, E. P. (2009). Interval from prostate biopsy to robot-assisted radical prostatectomy: effects on perioperative outcomes. BJU International, 104(11), 1734-7. https://doi.org/10.1111/j.1464-410X.2009.08685.x
Martin GL, et al. Interval From Prostate Biopsy to Robot-assisted Radical Prostatectomy: Effects On Perioperative Outcomes. BJU Int. 2009;104(11):1734-7. PubMed PMID: 19549123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interval from prostate biopsy to robot-assisted radical prostatectomy: effects on perioperative outcomes. AU - Martin,George L, AU - Nunez,Rafael N, AU - Humphreys,Mitchell D, AU - Martin,Aaron D, AU - Ferrigni,Robert G, AU - Andrews,Paul E, AU - Castle,Erik P, Y1 - 2009/06/22/ PY - 2009/6/25/entrez PY - 2009/6/25/pubmed PY - 2010/2/18/medline SP - 1734 EP - 7 JF - BJU international JO - BJU Int VL - 104 IS - 11 N2 - OBJECTIVE: To determine whether shorter intervals (<4 and 6 weeks) between prostate biopsy and robot-assisted radical prostatectomy (RARP) have a detrimental effect on perioperative outcomes, as recent studies showed that open RP shortly after prostate biopsy does not adversely influence surgical difficulty or efficacy, but RARP relies solely on visual cues rather than tactile sensation to determine posterior surgical planes of dissection. PATIENTS AND METHODS: A series of 559 patients undergoing RARP from March 2004 to July 2007 was retrospectively reviewed. The interval between prostate biopsy and RARP was determined and patients with intervals of <or=4 weeks were compared to those >4 weeks. Patient characteristics and perioperative outcomes were analysed to determine statistically significant differences between the groups. This comparison was then repeated with a <or=6- vs >6-week interval, and examined with a multivariate logistic regression analysis. RESULTS: In the <or=4-week group (27 patients) vs the >4-week group (509 patients), there was a significantly (P < 0.05) higher rate of complications (18.5% vs 6.9%). In the <or=6-week group (81 patients) vs the >6-week group (455 patients) there was a smaller but still significantly higher rate of complications (13.6% vs 6.4%). These results were still significant when controlling for patient and disease characteristics and the 'learning curve'. There was also a significantly higher rate of transfusion in the <or=6-week group (3.7%) than the >6-week group (0.7%). CONCLUSIONS: Our data suggest that RARP should be delayed after prostate biopsy; RARP within 6 weeks of biopsy was associated with a greater risk of complications even when controlling for disease and patient characteristics. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/19549123/Interval_from_prostate_biopsy_to_robot_assisted_radical_prostatectomy:_effects_on_perioperative_outcomes_ L2 - https://doi.org/10.1111/j.1464-410X.2009.08685.x DB - PRIME DP - Unbound Medicine ER -